Desyrel Dosage
Generic name: trazodone hydrochloride 50mg
Dosage form: tablet
Drug class: Phenylpiperazine antidepressants
Medically reviewed by Drugs.com. Last updated on Oct 14, 2024.
Dose Selection
An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any evidence of intolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage.
The dose may be increased by 50 mg/day every 3 to 4 days. The maximum dose for outpatients usually should not exceed 400 mg/day in divided doses. Inpatients (i.e., more severely depressed patients) may be given up to but not in excess of 600 mg/day in divided doses.
Once an adequate response has been achieved, dosage may be gradually reduced, with subsequent adjustment depending on therapeutic response.
Important Administration Instructions
DESYREL® can be swallowed whole or administered as a half tablet by breaking the tablet along the score line.
DESYREL should be taken shortly after a meal or light snack.
Screen for Bipolar Disorder Prior to Starting DESYREL
Prior to initiating treatment with DESYREL or another antidepressant, screen patients for a personal or family history of bipolar disorder, mania, or hypomania.
Switching to or from Monoamine Oxidase Inhibitor Antidepressant
At least 14 days must elapse between discontinuation of a monoamine oxidase inhibitor (MAOI) antidepressant and initiation of DESYREL. In addition, at least 14 days must elapse after stopping DESYREL before starting an MAOI antidepressant.
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