Desloratadine / Pseudoephedrine Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 19, 2024.

Applies to desloratadine / pseudoephedrine: oral tablet extended release 12 hr, oral tablet extended release 24 hr.

Precautions

Desloratadine may cause dryness of the mouth, nose, and throat. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Other side effects

Some side effects of desloratadine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects

Along with its needed effects, desloratadine/pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desloratadine / pseudoephedrine:

Observed during clinical practice

• Abdominal or stomach pain area
• chills
• clay-colored stools
• cough
• dark urine
• difficult or labored breathing
• difficulty swallowing
• dizziness
• elevated liver enzymes
• fast heartbeat
• fast, pounding, or irregular heartbeat or pulse
• fever
• general tiredness and weakness
• headache
• hives
• irregular heartbeat
• itching
• light-colored stools
• loss of appetite
• nausea
• puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
• rash
• redness of skin
• shortness of breath
• skin rash
• swelling
• tightness in chest
• unpleasant breath odor
• unusual tiredness or weakness
• upper right abdominal pain
• vomiting of blood
• vomiting
• welts
• wheezing
• yellow eyes or skin

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking desloratadine / pseudoephedrine:

• Increased heart rate
• sleepiness or unusual drowsiness

For healthcare professionals

Applies to desloratadine / pseudoephedrine: oral tablet extended release.

Psychiatric adverse events

• Very common (10% or more): Insomnia (10%)^[Ref]

Cardiovascular

• Frequency not reported: Arrhythmias, cardiovascular collapse with accompanying hypotension
• Postmarketing reports: Tachycardia, palpitations^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions (including rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis)^[Ref]

Nervous system

• Common (1% to 10%): Headache, somnolence, dizziness
• Frequency not reported: Insomnia, tremor, nervous system stimulation with convulsions^[Ref]

Gastrointestinal

• Common (1% to 10%): Mouth dry, nausea^[Ref]

Dermatologic

• Frequency not reported: Severe skin reactions
• Postmarketing reports: Rash, pruritus^[Ref]

Metabolic

• Common (1% to 10%): Anorexia^[Ref]

Ocular

• Frequency not reported: Narrow-angle glaucoma^[Ref]

Genitourinary

• Frequency not reported: Urinary retention in patients with prostatic hypertrophy^[Ref]

Respiratory

• Common (1% to 10%): Pharyngitis
• Postmarketing reports: Dyspnea^[Ref]

Other

• Frequency not reported: Weakness^[Ref]

See also:

Further information

Desloratadine/pseudoephedrine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer