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Desloratadine and pseudoephedrine

Generic Name: desloratadine and pseudoephedrine (DES loe RAT a deen and SOO doe ee FED rin)
Brand Name: Clarinex-D 12 Hour, Clarinex-D 24 Hour

Medically reviewed by Drugs.com on Mar 2, 2018 – Written by Cerner Multum

What is desloratadine and pseudoephedrine?

Desloratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Desloratadine and pseudoephedrine is a combination medicine used to treat sneezing, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

desloratadine and pseudoephedrine is for adults and children who are at least 12 years old.

Desloratadine and pseudoephedrine may also be used for purposes not listed in this medication guide.

Important Information

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use desloratadine and pseudoephedrine if you are allergic to desloratadine, loratadine (Claritin), or pseudoephedrine, or if you have:

Do not use desloratadine and pseudoephedrine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

  • kidney disease;

  • glaucoma;

  • heart disease or high blood pressure;

  • diabetes;

  • thyroid disorder; or

  • an enlarged prostate.

Desloratadine and pseudoephedrine should not be given to a child younger than 12 years old.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast feed while using desloratadine and pseudoephedrine.

How should I take desloratadine and pseudoephedrine?

Use exactly as directed on the label, or as prescribed by your doctor. Cold or allergy medicine is only for short-term use until your symptoms clear up.

Swallow the tablet whole and do not crush, chew, or break it.

Call your doctor if your symptoms do not improve after 7 days, or if you have a fever.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since desloratadine and pseudoephedrine is used when needed, you may not be on a daily dosing schedule. If you are on a schedule, take the medicine as soon as you can but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause anxiety, trouble sleeping, headache, vomiting, thirst, muscle weakness, fast or pounding heartbeats, hallucinations, shallow breathing, or a seizure.

What should I avoid while taking desloratadine and pseudoephedrine?

desloratadine and pseudoephedrine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Drinking alcohol with this medicine can cause side effects.

Ask a doctor or pharmacist before using over-the-counter medicines. They may contain ingredients similar to desloratadine and pseudoephedrine.

Desloratadine and pseudoephedrine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • tremors;

  • severe weakness;

  • irregular heartbeats;

  • a seizure; or

  • a severe skin reaction--fever, skin redness, small pimples.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Desloratadine and pseudoephedrine dosing information

Usual Adult Dose for Allergic Rhinitis:

desloratadine-pseudoephedrine 2.5 mg-120 mg oral tablet, extended release:
one extended release tablet orally twice daily, administered approximately 12 hours apart

desloratadine-pseudoephedrine 5 mg-240 mg oral tablet, extended release:
one extended release tablet orally once daily

Usual Pediatric Dose for Allergic Rhinitis:

12 yrs or older:
desloratadine-pseudoephedrine 2.5 mg-120 mg oral tablet, extended release:
one extended release tablet orally twice daily, administered approximately 12 hours apart

desloratadine-pseudoephedrine 5 mg-240 mg oral tablet, extended release:
one extended release tablet orally once daily

What other drugs will affect desloratadine and pseudoephedrine?

Using desloratadine and pseudoephedrine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Ask a doctor or pharmacist before using desloratadine and pseudoephedrine with any other medications, especially:

This list is not complete. Other drugs may affect desloratadine and pseudoephedrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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