Cortisone Side Effects
For the Consumer
Applies to cortisone: tablets
Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur while taking cortisone:
Difficulty sleeping; dizziness or lightheadedness; headache; increased appetite; increased sweating; indigestion; nervousness.
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in menstrual periods; chest pain; eye pain or increased pressure in the eye; fever, chills, or sore throat; joint or bone pain; mood or mental changes (eg, depression); muscle pain or weakness; seizures; severe or persistent nausea or vomiting; stomach pain or bloating; swelling of feet or legs; unusual weight gain or loss; vision changes; vomiting material that looks like coffee grounds.
For Healthcare Professionals
Applies to cortisone: compounding powder, injectable suspension, oral tablet
Cardiovascular side effects including myocardial rupture following recent myocardial infarction, fluid retention, sodium retention, congestive heart failure, potassium loss, hypokalemic alkalosis, and hypertension have been reported with cortisone therapy.[Ref]
Gastrointestinal side effects including peptic ulcer with potential perforation and hemorrhage, perforation of small and large bowel, pancreatitis, abdominal distention, nausea, increased appetite, and ulcerative esophagitis have been reported.[Ref]
Musculoskeletal side effects including muscle weakness, steroid myopathy, loss of muscle mass, osteoporosis, vertebral compression fractures, aseptic necrosis of femoral and humoral heads, pathologic fracture of long bones, and tendon rupture have been reported.[Ref]
Psychiatric side effects including euphoria, insomnia, mood swings, personality changes, severe depression, and psychotic manifestations have been reported.[Ref]
Nervous system side effects including convulsions, increased intracranial pressure with papilledema, vertigo, myalgia, arthralgia, malaise, headache, and psychic disturbances have been reported.[Ref]
Endocrine side effects including development of cushingoid state, suppression of growth in children, and secondary adrenocortical and pituitary unresponsiveness have been reported.[Ref]
Ocular side effects including posterior subcapsular cataracts, increased intraocular pressure, glaucoma, and exophthalmos have been reported.[Ref]
Thromboembolism has rarely been reported.[Ref]
Increase/decrease in motility and number of spermatozoa in men and menstrual irregularities in women have been reported rarely.[Ref]
1. "Product Information. Cortone Acetate (cortisone)." Merck & Co, Inc, West Point, PA.
2. Jorgensen H, Stiris G "Hypertensive crisis followed by adrenocortical insufficiency after unilateral adrenal phlebography in a patient with Cushing's syndrome." Acta Med Scand 196 (1974): 141-3
Not all side effects for cortisone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about cortisone
- Other brands: Cortone Acetate
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