Consensi Side Effects

Generic name: amlodipine / celecoxib

Medically reviewed by Drugs.com. Last updated on Aug 21, 2023.

Note: This document provides detailed information about Consensi Side Effects associated with amlodipine / celecoxib. Some dosage forms listed on this page may not apply specifically to the brand name Consensi.

Applies to amlodipine / celecoxib: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Do not stop using this medicine without asking your doctor, even if the pain stops and you feel well. Wait until your doctor prescribes a different medicine to treat your blood pressure.

Using this medicine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease or in people who use this medicine for a longer time.

This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (such as a steroid or a blood thinner).

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs, severe stomach pain, black, tarry stools, or vomiting of blood or material that looks like coffee grounds, unusual weight gain, yellow skin or eyes, decreased urination, unusual bleeding or bruising, or skin rash. Also, signs of serious heart problems could occur including chest pain or tightness, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Check with your doctor immediately if you notice any of these warning signs.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) can occur during treatment with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop treatment for a while, or to change to a different NSAID before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Consensi

Some side effects of amlodipine / celecoxib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Consensi

Along with its needed effects, amlodipine / celecoxib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / celecoxib:

For healthcare professionals

Applies to amlodipine / celecoxib: oral tablet.

General adverse events

The most commonly reported adverse events included infection, headache, edema, hypertension, and diarrhea.^[Ref]

Nervous system

Amlodipine:

• Common (1% to 10%): Dizziness, somnolence
• Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paresthesia, tremor, vertigo

Celecoxib:

• Very common (10% or more): Headache (up to 15.8%)
• Common (1% to 10%): Dizziness
• Uncommon (0.1% to 1%): Cerebral infarction
• Frequency not reported: Hypertonia, hypoesthesia, migraine, paresthesia, vertigo, somnolence, cerebrovascular accident, syncope, ataxia
• Postmarketing reports: Aseptic meningitis, dysgeusia, anosmia, fatal intracranial hemorrhage^[Ref]

Other

Amlodipine:

• Very common (10% or more): Edema (up to 14.6%)
• Common (1% to 10%): Fatigue, asthenia
• Uncommon (0.1% to 1%): Chest pain, malaise, pain, tinnitus

Celecoxib:

• Common (1% to 10%): Peripheral edema, accidental injury, pyrexia, injury and poisoning
• Frequency not reported: Chest pain, cyst not otherwise specified, edema generalized, face edema, fatigue, influenza-like symptoms, pain, peripheral pain, deafness, tinnitus, alkaline phosphatase increased, sudden death, blood culture positive^[Ref]

Cardiovascular

Amlodipine:

• Common (1% to 10%): Flushing, palpitation
• Uncommon (0.1% to 1%): Arrhythmia, bradycardia, tachycardia, vasculitis, peripheral ischemia, hot flushes

Celecoxib:

• Very common (10% or more): Hypertension (up to 12.5%)
• Uncommon (0.1% to 1%): Angina unstable, aortic valve incompetence, coronary artery atherosclerosis, sinus bradycardia, ventricular hypertrophy, deep vein thrombosis
• Frequency not reported: Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction, hot flushes, palpitation, tachycardia, congestive heart failure, ventricular fibrillation, thrombophlebitis, blood pressure increased
• Postmarketing reports: Vasculitis^[Ref]

Gastrointestinal

Amlodipine:

• Common (1% to 10%): Nausea, abdominal pain
• Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia, dry mouth

Celecoxib:

• Very common (10% or more): Diarrhea (up to 10.5%)
• Common (1% to 10%): Dyspepsia, abdominal pain, nausea, flatulence, abdominal pain upper, vomiting, gastroesophageal reflux disease
• Frequency not reported: Constipation, diverticulitis, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, hemorrhoids, hiatal hernia, melena, dry mouth, stomatitis, tenesmus, intestinal obstruction, intestinal perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus, post-dental extraction alveolar osteitis, upper gastrointestinal ulcers^[Ref]

Respiratory

Amlodipine:

• Common (1% to 10%): Dyspnea
• Uncommon (0.1% to 1%): Epistaxis

Celecoxib:

• Common (1% to 10%): Upper respiratory infection, sinusitis, pharyngitis, rhinitis, nasopharyngitis, cough, dyspnea
• Frequency not reported: Epistaxis, bronchitis, bronchospasm, bronchospasm aggravated, laryngitis, pneumonia, pulmonary embolism^[Ref]

Musculoskeletal

Amlodipine:

• Common (1% to 10%): Muscle cramps
• Uncommon (0.1% to 1%): Arthralgia, arthrosis, myalgia, back pain, rigors

Celecoxib:

• Common (1% to 10%): Back pain, arthralgia
• Uncommon (0.1% to 1%): Epicondylitis, tendon rupture
• Frequency not reported: Leg cramps, creatine phosphokinase increased, arthrosis, myalgia, synovitis, tendinitis, blood creatine phosphokinase increased^[Ref]

Dermatologic

Amlodipine:

• Common (1% to 10%): Pruritus, rash
• Uncommon (0.1% to 1%): Angioedema, erythema multiforme, rash erythematosus, rash maculopapular, sweating increased, purpura

Celecoxib:

• Common (1% to 10%): Rash
• Frequency not reported: Ecchymosis, alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematosus, rash maculopapular, skin disorder, skin dry, sweating increased, urticaria, dermatitis contact
• Postmarketing reports: Angioedema^[Ref]

Psychiatric

Amlodipine:

• Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization

Celecoxib:

• Common (1% to 10%): Insomnia
• Frequency not reported: Anxiety, depression, nervousness, suicide^[Ref]

Ocular

Amlodipine:

• Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain

Celecoxib:

• Common (1% to 10%): Eye disorders
• Uncommon (0.1% to 1%): Vitreous floaters, conjunctival hemorrhage^[Ref]

Genitourinary

Amlodipine:

• Common (1% to 10%): Sexual dysfunction
• Uncommon (0.1% to 1%): Micturition frequency, micturition disorder, nocturia

Celecoxib:

• Uncommon (0.1% to 1%): Ovarian cyst
• Frequency not reported: Albuminuria, dysuria, hematuria, micturition frequency, bacteriuria present, hematuria present, proteinuria present, urine analysis abnormal^[Ref]

Metabolic

Amlodipine:

• Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst

Celecoxib:

• Uncommon (0.1% to 1%): Blood potassium increased, blood sodium increased
• Frequency not reported: Hypercholesterolemia, hyperglycemia, hypokalemia, weight increased, anorexia, appetite increased, blood glucose increased, blood uric acid increased
• Postmarketing reports: Hypoglycemia, hyponatremia^[Ref]

Hematologic

Amlodipine:

• Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Celecoxib:

• Uncommon (0.1% to 1%): Hemoglobin decreased by more than 2 g/dL, anemia
• Frequency not reported: Thrombocythemia, thrombocytopenia, activated partial thromboplastin time prolonged, hematocrit decreased, hemoglobin decreased
• Postmarketing reports: Agranulocytosis, aplastic anemia, pancytopenia, leucopenia^[Ref]

Hepatic

Amlodipine:

• Postmarketing reports: Jaundice, hepatic enzyme elevations

Celecoxib:

• Common (1% to 10%): ALT or AST elevation of 1.2 to less than 3 times the upper limit of normal
• Uncommon (0.1% to 1%): ALT or AST elevation of 3 or more times the upper limit of normal
• Frequency not reported: Cholelithiasis, liver function tests abnormal, transaminase increased
• Postmarketing reports: Liver necrosis, hepatitis, jaundice, hepatic failure^[Ref]

Endocrine

Amlodipine:

• Postmarketing reports: Gynecomastia

Celecoxib:

• Uncommon (0.1% to 1%): Blood testosterone decreased^[Ref]

Immunologic

Amlodipine:

• Uncommon (0.1% to 1%): Allergic reaction

Celecoxib:

• Very common (10% or more): Infection (up to 25%)
• Uncommon (0.1% to 1%): Labyrinthitis
• Frequency not reported: Hypersensitivity, allergic reaction, cellulitis, cystitis, peripheral gangrene, sepsis
• Postmarketing reports: Anaphylactoid reaction^[Ref]

Renal

Celecoxib:

• Common (1% to 10%): Nephrolithiasis
• Frequency not reported: BUN increased, non-protein nitrogen increased, creatinine increased, renal calculus, acute renal failure
• Postmarketing reports: Interstitial nephritis^[Ref]

See also:

Frequently asked questions

• What drugs are contained in Consensi?

Further information

Consensi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer