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Clarinex-D 24 Hour Side Effects

Generic name: desloratadine / pseudoephedrine

Medically reviewed by Last updated on Aug 26, 2023.

Note: This document contains side effect information about desloratadine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Clarinex-D 24 Hour.

Applies to desloratadine / pseudoephedrine: oral tablet extended release 12 hr, oral tablet extended release 24 hr.

Serious side effects of Clarinex-D 24 Hour

Along with its needed effects, desloratadine/pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desloratadine / pseudoephedrine:

Observed during clinical practice

  • Abdominal or stomach pain area
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness
  • elevated liver enzymes
  • fast heartbeat
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general tiredness and weakness
  • headache
  • hives
  • irregular heartbeat
  • itching
  • light-colored stools
  • loss of appetite
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rash
  • redness of skin
  • shortness of breath
  • skin rash
  • swelling
  • tightness in chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting of blood
  • vomiting
  • welts
  • wheezing
  • yellow eyes or skin

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking desloratadine / pseudoephedrine:

  • Increased heart rate
  • sleepiness or unusual drowsiness

Other side effects of Clarinex-D 24 Hour

Some side effects of desloratadine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Body aches or pain
  • congestion
  • dryness or soreness of throat
  • hoarseness
  • nervousness
  • restlessness
  • runny nose
  • sleepiness or unusual drowsiness
  • tender, swollen glands in neck
  • trouble sitting still
  • voice changes
  • weight loss

For Healthcare Professionals

Applies to desloratadine / pseudoephedrine: oral tablet extended release.


Very common (10% or more): Insomnia (10%)[Ref]


Frequency not reported: Arrhythmias, cardiovascular collapse with accompanying hypotension

Postmarketing reports: Tachycardia, palpitations[Ref]


Frequency not reported: Hypersensitivity reactions (including rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis)[Ref]

Nervous system

Common (1% to 10%): Headache, somnolence, dizziness

Frequency not reported: Insomnia, tremor, nervous system stimulation with convulsions[Ref]


Common (1% to 10%): Mouth dry, nausea[Ref]


Frequency not reported: Severe skin reactions

Postmarketing reports: Rash, pruritus[Ref]


Common (1% to 10%): Anorexia[Ref]


Frequency not reported: Narrow-angle glaucoma[Ref]


Frequency not reported: Urinary retention in patients with prostatic hypertrophy[Ref]


Common (1% to 10%): Pharyngitis

Postmarketing reports: Dyspnea[Ref]


Frequency not reported: Weakness[Ref]


1. Product Information. Clarinex-D 12 Hour (desloratadine-pseudoephedrine). Schering-Plough Healthcare Products. 2019.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.