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Chlorthalidone Side Effects

For the Consumer

Applies to chlorthalidone: oral tablet

In addition to its needed effects, some unwanted effects may be caused by chlorthalidone. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking chlorthalidone:

Incidence not known:
  • Abdominal or stomach pain
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of skin
  • bloating
  • blood in urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • chills
  • clay-colored stools
  • cold sweats
  • confusion
  • constipation
  • cough or hoarseness
  • coughing up blood
  • darkened urine
  • diarrhea
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • dry mouth
  • fast heartbeat
  • fatigue
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • general feeling of tiredness or weakness
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • itching
  • joint pain, stiffness, or swelling
  • loss of appetite
  • lower back or side pain
  • nausea
  • pain in joints or muscles
  • painful or difficult urination
  • pains in stomach, side, or abdomen, possibly radiating to the back
  • pinpoint red spots on skin
  • red irritated eyes
  • red skin lesions, often with a purple center
  • redness, soreness or itching skin
  • shortness of breath
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • sores, welting, or blisters
  • sugar in the urine
  • sweating
  • swelling of feet or lower legs
  • swollen glands
  • tightness in chest
  • troubled breathing
  • unpleasant breath odor
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight loss
  • vomiting
  • vomiting of blood
  • weight loss
  • wheezing
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with chlorthalidone may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Cramping
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • feeling of constant movement of self or surroundings
  • hives
  • inability to have or keep an erection
  • increased sensitivity of skin to sunlight
  • loss in sexual ability, desire, drive, or performance
  • muscle spasm
  • redness or other discoloration of skin
  • restlessness
  • sensation of spinning
  • severe sunburn
  • weakness

For Healthcare Professionals

Applies to chlorthalidone: oral tablet

Cardiovascular

Common (1% to 10%): Postural hypotension
Rare (less than 0.1%): Cardiac arrhythmias[Ref]

Dermatologic

Common (1% to 10%): Urticaria, rash
Rare (less than 0.1%): Photosensitivity
Frequency not reported: Purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis)[Ref]

Gastrointestinal

Common (1% to 10%): GI discomfort, anorexia
Rare (0.01% to 0.1%): Nausea, vomiting, upper abdominal pain, constipation, diarrhea
Very rare (less than 0.01%): Pancreatitis
Frequency not reported: Cramping[Ref]

Genitourinary

Common (1% to 10%): Impotence
Frequency not reported: Glycosuria[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia, leucopenia, agranulocytosis
eosinophilia
Frequency not reported: Aplastic anemia[Ref]

Metabolic

Very common (10% or more): Hypokalemia, hyperuricemia, hyperlipidemia
Common (1% to 10%): Hyponatremia, hypomagnesemia, hyperglycemia
Uncommon (0.1% to 1%): Gout
Rare (0.01% to 0.1%): Hypercalcemia, inadequate control of diabetes mellitus
Very rare (less than 0.01%): Hypochloremic alkalosis[Ref]

Hepatic

Rare (less than 0.1%): Intrahepatic cholestasis or jaundice[Ref]

Hypersensitivity

Hypersensitivity reactions usually involve the skin (see DERMATOLOGIC).[Ref]

Musculoskeletal

Frequency not reported: Muscle spasm[Ref]

Nervous system

Common (1% to 10%): Dizziness
Rare (less than 0.1%): Paresthesia, headache
Frequency not reported: Vertigo[Ref]

Other

Frequency not reported: Vertigo, weakness[Ref]

Ocular

Rare (less than 0.1%): Visual impairment
Frequency not reported: Xanthopsia[Ref]

Psychiatric

Frequency not reported: Restlessness[Ref]

Respiratory

Very rare (less than 0.01%): Noncardiogenic pulmonary edema[Ref]

References

1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for chlorthalidone may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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