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Chlorthalidone Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 8, 2023.

Applies to chlorthalidone: oral tablet.

Serious side effects of Chlorthalidone

Along with its needed effects, chlorthalidone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chlorthalidone:

Incidence not known

Other side effects of Chlorthalidone

Some side effects of chlorthalidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to chlorthalidone: oral tablet.

Cardiovascular

Common (1% to 10%): Postural hypotension

Rare (less than 0.1%): Cardiac arrhythmias[Ref]

Dermatologic

Common (1% to 10%): Urticaria, rash

Rare (less than 0.1%): Photosensitivity

Frequency not reported: Purpura, necrotizing angiitis (vasculitis, cutaneous vasculitis), Lyell's syndrome (toxic epidermal necrolysis)[Ref]

Gastrointestinal

Common (1% to 10%): GI discomfort, anorexia

Rare (0.01% to 0.1%): Nausea, vomiting, upper abdominal pain, constipation, diarrhea

Very rare (less than 0.01%): Pancreatitis

Frequency not reported: Cramping[Ref]

Genitourinary

Common (1% to 10%): Impotence

Frequency not reported: Glycosuria[Ref]

Hematologic

Rare (less than 0.1%): Thrombocytopenia, leucopenia, agranulocytosis

eosinophilia

Frequency not reported: Aplastic anemia[Ref]

Metabolic

Very common (10% or more): Hypokalemia, hyperuricemia, hyperlipidemia

Common (1% to 10%): Hyponatremia, hypomagnesemia, hyperglycemia

Uncommon (0.1% to 1%): Gout

Rare (0.01% to 0.1%): Hypercalcemia, inadequate control of diabetes mellitus

Very rare (less than 0.01%): Hypochloremic alkalosis[Ref]

Hepatic

Rare (less than 0.1%): Intrahepatic cholestasis or jaundice[Ref]

Hypersensitivity

Hypersensitivity reactions usually involve the skin (see DERMATOLOGIC).[Ref]

Musculoskeletal

Frequency not reported: Muscle spasm[Ref]

Nervous system

Common (1% to 10%): Dizziness

Rare (less than 0.1%): Paresthesia, headache

Frequency not reported: Vertigo[Ref]

Other

Frequency not reported: Vertigo, weakness[Ref]

Ocular

Rare (less than 0.1%): Visual impairment

Frequency not reported: Xanthopsia[Ref]

Psychiatric

Frequency not reported: Restlessness[Ref]

Respiratory

Very rare (less than 0.01%): Noncardiogenic pulmonary edema[Ref]

Frequently asked questions

References

1. Cerner Multum, Inc. UK Summary of Product Characteristics.

2. Cerner Multum, Inc. Australian Product Information.

3. Product Information. Chlorthalidone (chlorthalidone). Sun Pharmaceutical Industries. 2016.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.