Skip to Content

Chlorthalidone Pregnancy and Breastfeeding Warnings

Chlorthalidone is also known as: Hygroton, Thalitone

Chlorthalidone Pregnancy Warnings

This drug did not produce teratogenic toxicity in animal studies. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details. US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

This drug should be used during pregnancy only if the benefit outweighs the risk. AU TGA pregnancy category: C US FDA pregnancy category: B Comments: -The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard. -Diuretics can cause placental hypoperfusion. Since they do not prevent or alter the course of preeclampsia, they should not be used to treat hypertension in pregnant women. -This drug enters the fetal circulation and may cause electrolyte disturbances. -When given late in pregnancy, this drug can cause neonatal thrombocytopenia, fetal bone marrow depression, and fetal and neonatal jaundice. -Diuretics are not recommended for the treatment of gestational hypertension because of the maternal hypovolemia characteristic of this disease.

See references

Chlorthalidone Breastfeeding Warnings

Use should be avoided. Excreted into human milk: Yes

Although this drug is only excreted into milk in small amounts, it is cleared slowly and can accumulate in the infant, especially newborns or preterm infants. It may also suppress lactation.

See references

References for pregnancy information

  1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

References for breastfeeding information

  1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

Hide