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Chlorthalidone Pregnancy and Breastfeeding Warnings

Chlorthalidone is also known as: Hygroton, Thalitone

Medically reviewed by Drugs.com. Last updated on Oct 11, 2019.

Chlorthalidone Pregnancy Warnings

Animal studies have failed to allow the calculation of comparisons between the exposure of this drug to the systemic exposure that would be expected in humans. There are no controlled data in human pregnancy.

AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.

US FDA pregnancy category Not Assigned: The US FDA has amended the pregnancy labeling rule for prescription drug products to require labeling that includes a summary of risk, a discussion of the data supporting that summary, and relevant information to help health care providers make prescribing decisions and counsel women about the use of drugs during pregnancy. Pregnancy categories A, B, C, D, and X are being phased out.

Use should be avoided; per some authorities, use is contraindicated for hypertension during pregnancy.

AU TGA pregnancy category: C
US FDA pregnancy category: Not assigned.

Risk Summary: Adverse fetal outcomes, including fetal or neonatal jaundice, thrombocytopenia, hypoglycemia, and electrolyte abnormalities have been reported following maternal use of thiazide diuretics.

Comments:
-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
-This drug enters fetal circulation and can cause placental hypoperfusion.

See references

Chlorthalidone Breastfeeding Warnings

Use should be avoided.

Excreted into human milk: Yes

Although this drug is only excreted into milk in small amounts, it is cleared slowly and can accumulate in the infant, especially newborns or preterm infants. It may also suppress lactation.

See references

References for pregnancy information

  1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

References for breastfeeding information

  1. Cerner Multum, Inc. "Australian Product Information." O 0
  2. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.