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Chlorthalidone Pregnancy and Breastfeeding Warnings

Chlorthalidone is also known as: Hygroton, Thalitone

Medically reviewed on February 23, 2018

Chlorthalidone Pregnancy Warnings

This drug did not produce teratogenic toxicity in animal studies.

AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Accompanying texts should be consulted for further details.

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

This drug should be used during pregnancy only if the benefit outweighs the risk.

AU TGA pregnancy category: C
US FDA pregnancy category: B

Comments:
-The routine use of diuretics in an otherwise healthy woman is inappropriate and exposes mother and fetus to unnecessary hazard.
-Diuretics can cause placental hypoperfusion. Since they do not prevent or alter the course of preeclampsia, they should not be used to treat hypertension in pregnant women.
-This drug enters the fetal circulation and may cause electrolyte disturbances.
-When given late in pregnancy, this drug can cause neonatal thrombocytopenia, fetal bone marrow depression, and fetal and neonatal jaundice.
-Diuretics are not recommended for the treatment of gestational hypertension because of the maternal hypovolemia characteristic of this disease.

See references

Chlorthalidone Breastfeeding Warnings

Use should be avoided.

Excreted into human milk: Yes

Although this drug is only excreted into milk in small amounts, it is cleared slowly and can accumulate in the infant, especially newborns or preterm infants. It may also suppress lactation.

See references

References for pregnancy information

  1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  3. Cerner Multum, Inc. "Australian Product Information." O 0

References for breastfeeding information

  1. "Product Information. Chlorthalidone (chlorthalidone)." Sun Pharmaceutical Industries, Cranbury, NJ.
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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