Ceftibuten Side Effects
Medically reviewed by Drugs.com. Last updated on Jul 14, 2022.
Summary
More frequently reported side effects include: nausea. Continue reading for a comprehensive list of adverse effects.
Applies to ceftibuten: oral capsules, oral for suspension.
Side effects include:
GI effects (e.g., nausea, diarrhea, dyspepsia, vomiting, abdominal pain), headache, dizziness, increased BUN concentrations, eosinophilia.
For Healthcare Professionals
Applies to ceftibuten: oral capsule, oral powder for reconstitution.
General
This drug was generally well tolerated. In clinical trials, 2% of patients discontinued medication due to adverse events, primarily diarrhea, nausea, or vomiting, and 0.3% discontinued due to rash or pruritus.[Ref]
Gastrointestinal
The onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.[Ref]
Common (1% to 10%): Nausea, diarrhea, dyspepsia, abdominal pain, vomiting
Uncommon (0.1% to 1%): Constipation, dry mouth, eructation, flatulence, loose stools
Postmarketing reports: Melena
Cephalosporin-class:
-Frequency not reported: Pseudomembranous colitis[Ref]
Nervous system
Some cephalosporins have been associated with seizures, especially in patients with renal dysfunction whose dose was not reduced.[Ref]
Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Somnolence, taste perversion, paresthesia
Frequency not reported: Hyperkinesia
Postmarketing reports: Aphasia
Cephalosporin-class:
-Frequency not reported: Seizures[Ref]
Hepatic
Common (1% to 10%): Increased ALT, increased bilirubin
Uncommon (0.1% to 1%): Increased AST
Postmarketing reports: Jaundice
Cephalosporin-class:
-Frequency not reported: Hepatic cholestasis[Ref]
Hematologic
Common (1% to 10%): Increased eosinophils, decreased hemoglobin
Uncommon (0.1% to 1%): Increased platelets, decreased platelets, decreased leukocytes
Cephalosporin-class:
-Frequency not reported: Aplastic anemia, hemolytic anemia, prolonged prothrombin time, hemorrhage, neutropenia, pancytopenia, agranulocytosis[Ref]
Renal
Common (1% to 10%): Increased BUN
Uncommon (0.1% to 1%): Increased creatinine
Cephalosporin-class:
-Frequency not reported: Renal dysfunction, toxic nephropathy[Ref]
Dermatologic
Uncommon (0.1% to 1%): Pruritus, rash, urticaria
Frequency not reported: Diaper dermatitis
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis
Cephalosporin-class:
-Frequency not reported: Stevens-Johnson syndrome, erythema multiforme[Ref]
Other
Uncommon (0.1% to 1%): Fatigue, moniliasis, increased alkaline phosphatase
Frequency not reported: Fever, rigors, transient increases in lactate dehydrogenase
Cephalosporin-class:
-Frequency not reported: Drug fever[Ref]
Metabolic
Uncommon (0.1% to 1%): Anorexia
Frequency not reported: Dehydration
Cephalosporin-class:
-Frequency not reported: False-positive test for urinary glucose[Ref]
Respiratory
Uncommon (0.1% to 1%): Dyspnea, nasal congestion
Postmarketing reports: Stridor[Ref]
Genitourinary
Uncommon (0.1% to 1%): Dysuria, vaginitis
Frequency not reported: Hematuria[Ref]
Psychiatric
Frequency not reported: Agitation, irritability, insomnia
Postmarketing reports: Psychosis[Ref]
Hypersensitivity
Postmarketing reports: Serum sickness-like reactions
Cephalosporin-class:
-Frequency not reported: Allergic reactions, anaphylaxis[Ref]
More about ceftibuten
- Check interactions
- Reviews (3)
- Dosage information
- During pregnancy
- Drug class: third generation cephalosporins
- Breastfeeding
Patient resources
Other brands
Professional resources
Related treatment guides
References
1. "Product Information. Cedax (ceftibuten)." Schering-Plough (2001):
2. Owens RC, Nightingale CH, Nicolau DP "Ceftibuten: an overview." Pharmacotherapy 17 (1997): 707-20
3. Aubier MA "Comparison of ceftibuten versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis." Chemotherapy 43 (1997): 297-302
4. Sterkers O "Efficacy and tolerability of ceftibuten versus amoxicillin/clavulanate in the treatment of acute sinusitis." Chemotherapy 43 (1997): 352-7
5. McAdoo MA, Rice K, Gordon GR, Sahn SA "Comparison of ceftibuten once daily and amoxicillin-clavulanate three times daily in the treatment of acute exacerbations of chronic bronchitis." Clin Ther 20 (1998): 88-100
6. Schatz BS, Karavokiros KT, Taeubel MA, Itokazu GS "Comparison of cefprozil, cefpodoxime proxetil, loracarbef, cefixime, and ceftibuten." Ann Pharmacother 30 (1996): 258-68
7. David RP "Ceftibuten: a new expanded-spectrum oral cephalsporin." Ann Pharmacother 31 (1997): 1022-33
8. "Ceftibuten--a new oral cephalosporin." Med Lett Drugs Ther 38 (1996): 23-4
9. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M "Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses." J Allerg Clin Immunol 106 (2000): 1177-83
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.