Skip to Content

Third generation cephalosporins

What are Third generation cephalosporins?

Cephalosporins are a large group of antibiotics derived from the mold Acremonium (previously called Cephalosporium). This mold yielded three main compounds, historically called Cephalosporin N and C, and P, from which the first cephalosporins were derived.

Cephalosporins are bactericidal (kill bacteria) and work in a similar way to penicillins. They bind to and block the activity of enzymes responsible for making peptidoglycan, an important component of the bacterial cell wall. They are called broad-spectrum antibiotics because they are effective against a wide range of bacteria.

Since the first cephalosporin was discovered in 1945, scientists have been improving the structure of cephalosporins to make them more effective against a wider range of bacteria. Each time the structure changes, a new "generation" of cephalosporins are made. So far there are five generations of cephalosporins. All cephalosporins start with cef, ceph, or kef.

Third generation cephalosporins followed the second generation cephalosporins. No one third generation cephalosporin treats all infectious disease scenarios. Cefotaxime and ceftizoxime offer the best gram-positive coverage out of all the third-generation agents; ceftazidime and cefoperazone are unique in that they provide antipseudomonal coverage. Ceftriaxone has a long half life which allows for once daily dosing and all of the third-generation cephalosporins except for cefoperazone penetrate cerebrospinal fluid.

List of Third generation cephalosporins:

Filter by:
Drug NameView by: Brand | Generic Reviews Avg. Ratings
Cedax (Pro, More...)
generic name: ceftibuten
3 reviews
Rocephin (Pro, More...)
generic name: ceftriaxone
79 reviews
Claforan (Pro, More...)
generic name: cefotaxime
0 reviews
Vantin (Pro, More...)
generic name: cefpodoxime
6 reviews
Omnicef (Pro, More...)
generic name: cefdinir
46 reviews
Suprax (Pro, More...)
generic name: cefixime
8 reviews
Omnicef Omni-Pac (More...)
generic name: cefdinir
2 reviews
Spectracef (Pro, More...)
generic name: cefditoren
3 reviews
Cefizox (More...)
generic name: ceftizoxime
0 reviewsAdd rating
Cefobid (More...)
generic name: cefoperazone
0 reviewsAdd rating
Ceptaz (More...)
generic name: ceftazidime
0 reviewsAdd rating
Fortaz (Pro, More...)
generic name: ceftazidime
0 reviewsAdd rating
Tazicef (Pro, More...)
generic name: ceftazidime
0 reviewsAdd rating