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cefpodoxime

Generic Name: cefpodoxime (SEF poe DOX eem)
Brand Name: Vantin

What is cefpodoxime?

Cefpodoxime is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body.

Cefpodoxime is used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, and urinary tract infections.

Cefpodoxime may also be used for purposes not listed in this medication guide.

What is the most important information I should know about cefpodoxime?

You should not use this medicine if you are allergic to cefpodoxime or to similar antibiotics, such as Ceftin, Cefzil, Omnicef, and others. Tell your doctor if you are allergic to any drugs, especially penicillins or other antibiotics.

What should I discuss with my healthcare provider before taking cefpodoxime?

You should not use this medicine if you are allergic to cefpodoxime or to other cephalosporin antibiotics, such as:

  • cefaclor (Raniclor);

  • cefadroxil (Duricef);

  • cefazolin (Ancef);

  • cefotetan (Cefotan);

  • cefditoren (Spectracef);

  • cefprozil (Cefzil);

  • ceftibuten (Cedax);

  • cefuroxime (Ceftin);

  • cephalexin (Keflex); or

  • cephradine (Velosef), and others.

To make sure cefpodoxime is safe for you, tell your doctor if you have ever had:

  • kidney disease; or

  • an allergy to any drugs (especially penicillins).

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.

Cefpodoxime can pass into breast milk and may affect the nursing baby. Tell your doctor if you are breast-feeding.

Cefpodoxime should not be given to a child younger than 2 months old.

How should I take cefpodoxime?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

The cefpodoxime tablet should be taken with food.

Cefpodoxime oral suspension (liquid) can be taken with or without food.

Shake the liquid well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Cefpodoxime can cause you to have false results with certain medical tests, including urine glucose (sugar) tests. Tell any doctor who treats you that you are using cefpodoxime.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefpodoxime will not treat a viral infection such as the flu or a common cold.

Store the tablets at room temperature away from moisture, heat, and light.

Store the liquid medicine in a tightly-closed bottle in the refrigerator. Do not freeze. Throw away any unused liquid after 14 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, stomach pain, and diarrhea.

What should I avoid while taking cefpodoxime?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ask your doctor before using an antacid, and use only the type your doctor recommends. Some antacids can make it harder for your body to absorb cefpodoxime.

Cefpodoxime side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • fever, swollen glands, rash or itching, joint pain, or general ill feeling;

  • pounding heartbeats or fluttering in your chest;

  • shortness of breath; or

  • a seizure.

Common side effects may include:

  • vaginal itching or discharge;

  • diaper rash in an infant using this medicine;

  • nausea, vomiting, diarrhea;

  • stomach pain; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Side Effects (complete list)

Cefpodoxime dosing information

Usual Adult Dose for Bronchitis:

Acute bacterial exacerbation of chronic bronchitis: 200 mg orally every 12 hours for 10 days

Usual Adult Dose for Cystitis:

100 mg orally every 12 hours for 7 days

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

Uncomplicated urethral, cervical, or female anorectal infections: 200 mg orally one time

Alternatively, the Centers for Disease Control and Prevention suggest 400 mg orally one time may be effective for both male and female patients as an oral alternative for the treatment of uncomplicated gonorrhea of the cervix, urethra, or rectum.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Cefpodoxime is not indicated for pharyngeal N gonorrhoeae infections.

Usual Adult Dose for Gonococcal Infection -- Disseminated:

400 mg orally twice a day

Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observed. Oral therapy may then be administered to complete a total course of at least 1 week.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Pneumonia:

Community-acquired pneumonia: 200 mg orally every 12 hours for 14 days

Usual Adult Dose for Pyelonephritis:

100 mg orally every 12 hours
Therapy should be continued for about 14 days, depending on the nature and severity of the infection.

Usual Adult Dose for Sinusitis:

200 mg orally every 12 hours for 10 days

Usual Adult Dose for Skin or Soft Tissue Infection:

Uncomplicated infection: 400 mg orally every 12 hours for 7 to 14 days

Usual Adult Dose for Tonsillitis/Pharyngitis:

100 mg orally every 12 hours for 5 to 10 days
There are insufficient data to establish efficacy in the subsequent prophylaxis of rheumatic fever.

Usual Adult Dose for Upper Respiratory Tract Infection:

100 mg orally every 12 hours
Therapy should be continued for approximately 10 to 14 days, depending on the nature and severity of the infection.

Usual Pediatric Dose for Bronchitis:

Acute bacterial exacerbation of chronic bronchitis:
12 years or older: 200 mg orally every 12 hours for 10 days

Usual Pediatric Dose for Cystitis:

12 years or older: 100 mg orally every 12 hours for 7 days

Usual Pediatric Dose for Gonococcal Infection -- Uncomplicated:

Uncomplicated urethral, cervical, or female anorectal infections:
12 years or older: 200 mg orally one time

Alternatively, the Centers for Disease Control and Prevention suggest 400 mg orally one time may be effective for both male and female patients as an oral alternative for the treatment of uncomplicated gonorrhea of the cervix, urethra, or rectum.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated.

Cefpodoxime is not indicated for pharyngeal N gonorrhoeae infections.

Usual Pediatric Dose for Gonococcal Infection -- Disseminated:

12 years or older: 400 mg orally twice a day

Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observed. Oral therapy may then be administered to complete a total course of at least 1 week.

Doxycycline therapy for 7 days (if not pregnant) or single dose azithromycin is also recommended to treat possible concurrent chlamydial infection.

The patient's sexual partner(s) should also be evaluated/treated.

Usual Pediatric Dose for Otitis Media:

2 months through 12 years: 5 mg/kg/dose (maximum 200 mg) orally every 12 hours for 5 days
Maximum dose: 400 mg/day

Usual Pediatric Dose for Pneumonia:

Community-acquired pneumonia:
12 years or older: 200 mg orally every 12 hours for 14 days

Usual Pediatric Dose for Sinusitis:

2 months through 12 years: 5 mg/kg/dose (maximum 200 mg) orally every 12 hours for 10 days
Maximum dose: 400 mg/day

12 years or older: 200 mg orally every 12 hours for 10 days

Usual Pediatric Dose for Skin or Soft Tissue Infection:

Uncomplicated infection:
12 years or older: 400 mg orally every 12 hours for 7 to 14 days

Usual Pediatric Dose for Tonsillitis/Pharyngitis:

2 months through 12 years: 5 mg/kg/dose (maximum 100 mg) orally every 12 hours for 5 to 10 days
Maximum dose: 200 mg/day

12 years or older: 100 mg orally every 12 hours for 5 to 10 days

There are insufficient data to establish efficacy in the subsequent prophylaxis of rheumatic fever.

What other drugs will affect cefpodoxime?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • probenecid;

  • antiviral medicine or other antibiotics;

  • chemotherapy, or medicine to prevent organ transplant rejection;

  • a diuretic or "water pill";

  • medicine for bowel disorders;

  • injectable osteoporosis medication;

  • a stomach acid reducer (Pepcid, Zantac, Tagamet, and others); or

  • pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve).

This list is not complete. Other drugs may interact with cefpodoxime, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about cefpodoxime.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 6.01.

Date modified: December 03, 2017
Last reviewed: November 09, 2017

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