Ceftibuten Dosage
Applies to the following strengths: 400 mg; 90 mg/5 mL; 180 mg/5 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Otitis Media
400 mg orally once a day for 10 days
Uses:
- For the treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae (including beta-lactamase-producing strains), Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only)
- For the treatment of acute bacterial otitis media due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pyogenes
- For the treatment of pharyngitis and tonsillitis due to S pyogenes
Usual Adult Dose for Tonsillitis/Pharyngitis
400 mg orally once a day for 10 days
Uses:
- For the treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae (including beta-lactamase-producing strains), Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only)
- For the treatment of acute bacterial otitis media due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pyogenes
- For the treatment of pharyngitis and tonsillitis due to S pyogenes
Usual Adult Dose for Bronchitis
400 mg orally once a day for 10 days
Uses:
- For the treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae (including beta-lactamase-producing strains), Moraxella catarrhalis (including beta-lactamase-producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only)
- For the treatment of acute bacterial otitis media due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pyogenes
- For the treatment of pharyngitis and tonsillitis due to S pyogenes
Usual Pediatric Dose for Bronchitis
12 years or older: 400 mg orally once a day for 10 days
Use: For the treatment of acute bacterial exacerbations of chronic bronchitis due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pneumoniae (penicillin-susceptible strains only)
Usual Pediatric Dose for Otitis Media
6 months to 11 years: 9 mg/kg orally once a day
- Maximum dose: 400 mg/day
Duration of therapy: 10 days
Uses:
- For the treatment of acute bacterial otitis media due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pyogenes
- For the treatment of pharyngitis and tonsillitis due to S pyogenes
Usual Pediatric Dose for Tonsillitis/Pharyngitis
6 months to 11 years: 9 mg/kg orally once a day
- Maximum dose: 400 mg/day
Duration of therapy: 10 days
Uses:
- For the treatment of acute bacterial otitis media due to H influenzae (including beta-lactamase-producing strains), M catarrhalis (including beta-lactamase-producing strains), or S pyogenes
- For the treatment of pharyngitis and tonsillitis due to S pyogenes
Renal Dose Adjustments
CrCl 30 to 49 mL/min:
- Adult patients (12 years or older): 200 mg orally every 24 hours
- Pediatric patients (6 months to 11 years): 4.5 mg/kg orally every 24 hours
- Maximum dose: 200 mg/day
CrCl 5 to 29 mL/min:
- Adult patients (12 years or older): 100 mg orally every 24 hours
- Pediatric patients (6 months to 11 years): 2.25 mg/kg orally every 24 hours
- Maximum dose: 100 mg/day
Liver Dose Adjustments
Data not available
Precautions
CONTRAINDICATIONS:
Known allergy to cephalosporin antibiotics
Safety and efficacy have not been established in patients younger than 6 months.
Consult WARNINGS section for additional precautions.
Dialysis
Hemodialysis (2 or 3 times a week):
- Adult patients (12 years or older): 400 mg orally at the end of each hemodialysis session
- Pediatric patients (6 months to 11 years): 9 mg/kg orally at the end of each hemodialysis session
- Maximum dose: 400 mg/dose
Peritoneal dialysis: Data not available
Comments:
- Hemodialysis removed 65% of the drug from the blood in 2 to 4 hours.
- Dialysis patients should be monitored carefully.
Other Comments
Administration advice:
- Administer the oral suspension at least 2 hours before or 1 hour after a meal.
- Shake the oral suspension well before each use.
- Use empirically for acute otitis media only after administering adequate coverage against S pneumoniae.
Storage requirements:
- Capsules and oral suspension (before reconstitution): Store between 2C and 25C (36F and 77F).
- Oral suspension (after reconstitution): Store in the refrigerator between 2C and 8C (36F and 46F) and keep tightly closed; discard after 14 days.
Reconstitution/preparation techniques:
- Oral suspension: The manufacturer product information should be consulted.
General:
- This drug is recommended for mild to moderate infections due to susceptible strains of the designated microorganisms in the specified indications.
- In acute bacterial exacerbations of chronic bronchitis studies, clinical efficacy of this drug was 22% less than control when M catarrhalis was isolated from infected sputum at baseline.
- Although empirical use of this drug was equal to comparators when treating clinically and/or microbiologically documented acute otitis media, its efficacy against S pneumoniae was 23% less than control.
- Only IM penicillin was shown effective to prevent rheumatic fever; this drug was generally effective in eradicating S pyogenes from the oropharynx but data showing efficacy for prophylaxis of subsequent rheumatic fever are not available.
- The oral suspension contains 1 g sucrose/5 mL.
Monitoring:
- Renal: Renal function in elderly patients
Patient advice:
- Avoid missing doses and complete the entire course of therapy.
More about ceftibuten
- Check interactions
- Compare alternatives
- Reviews (3)
- Side effects
- During pregnancy
- Drug class: third generation cephalosporins
- Breastfeeding
Patient resources
Other brands
Professional resources
Related treatment guides
See also:
Amoxicillin/clavulanate
Amoxicillin and clavulanate potassium is a combination antibiotic used to treat bacterial ...
Guaifenesin
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat. Includes ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Cefdinir
Cefdinir systemic is used for bacterial infection, bronchitis, middle ear infections, pneumonia ...
Levofloxacin
Levofloxacin is a fluoroquinolone antibiotic used to treat serious bacterial infections and prevent ...
Augmentin
Augmentin is a prescription antibiotic combining amoxicillin and clavulanate to treat bacterial ...
Ceftriaxone
Ceftriaxone systemic is used for bacteremia, bacterial endocarditis prevention, bacterial ...
Clindamycin
Clindamycin (Cleocin) is used to treat serious infections caused by bacteria. Includes clindamycin ...
Cephalexin
Cephalexin is a cephalosporin antibiotic used to treat bacterial infections like respiratory, skin ...
Metronidazole
Metronidazole is an antibiotic used to fight bacteria in your body. Learn about side effects ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.