Cefditoren Side Effects

In Summary

Commonly reported side effects of cefditoren include: diarrhea. Other side effects include: vulvovaginal candidiasis and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cefditoren: oral tablet

In addition to its needed effects, some unwanted effects may be caused by cefditoren. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking cefditoren:

• Allergic reaction, such as, itching, pain, redness, or swelling of eye or eyelid, watering of eyes, troubled breathing or wheezing, severe skin rash or hives, flushing, headache, fever, chills, runny nose, increased sensitivity to sunlight, joint pain, swollen glands
• leukopenia, such as, black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands, unusual bleeding or bruising, unusual tiredness, or weakness
• pseudomembranous colitis, such as, abdominal or stomach cramps, pain, bloating, abdominal tenderness, diarrhea, watery and severe, which may also be bloody, fever, increased thirst, nausea or vomiting, unusual tiredness or weakness, or unusual weight loss
• or thrombocythemia, such as, pain, warmth or burning in fingers, toes, and legs, dizziness, problems with vision or hearing

Minor Side Effects

Some of the side effects that can occur with cefditoren may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Diarrhea
• nausea
• or vaginal moniliasis, such as, thick whitish discharge from the vagina or cervical canal

• Abdominal pain
• Dyspepsia, such as, acid or sour stomach, belching, heartburn, indigestion, or stomach discomfort, upset or pain
• or headache

• Abnormal dreams
• anorexia, such as, loss of appetite
• asthenia, such as, lack or loss of strength
• constipation
• dizziness
• dry mouth
• dysgeusia, such as, taste perversion
• eructation, such as, belching, bloated full feeling, excess air or gas in stomach
• fever
• flatulence, such as, passing of gas
• fungal infection
• gastritis, such as, burning feeling in chest or stomach, tenderness in stomach area, stomach upset, or indigestion
• headache
• hyperglycemia, such as, blurred vision, dry mouth, fatigue, flushed, dry skin, fruit-like breath odor, increased hunger, increased thirst, increased urination, loss of consciousness, nausea, stomachache, sweating, troubled breathing, unexplained weight loss, vomiting
• increased appetite
• insomnia, such as, sleeplessness
• leukorrhea, such as, increase in amount of clear vaginal discharge, white vaginal discharge
• mouth ulceration
• myalgia, such as, muscle pain
• nervousness
• oral moniliasis, such as, sore mouth or tongue, white patches in mouth, tongue, or throat
• pain
• peripheral edema, such as, bloating or swelling of face, arms, hands, lower legs, or feet, rapid weight gain, tingling of hands or feet, unusual weight gain or loss
• pharyngitis, such as, body aches or pain, congestion, cough, dryness or soreness of throat, fever, hoarseness, runny nose, tender, swollen glands in neck, trouble in swallowing, or voice changes
• pruritus, such as, itching skin
• rash
• rhinitis, such as, stuffy nose, runny nose, or sneezing
• sinusitis, such as, pain or tenderness around eyes and cheekbones, fever, stuffy or runny nose, headache, cough, shortness of breath or troubled breathing, tightness of chest or wheezing
• somnolence, such as, sleepiness or unusual drowsiness
• stomatitis, such as, swelling or inflammation of the mouth
• sweating
• urinary frequency
• urticaria, such as, hives or welts, itching, redness of skin, or rash
• vaginitis
• vomiting
• or weight loss

For Healthcare Professionals

Applies to cefditoren: oral tablet

General

In clinical trials, cefditoren has been well tolerated. Most adverse effects were mild and self-limiting, and the overall incidence was higher with increased dosage.^[Ref]

Gastrointestinal

Onset of pseudomembranous colitis symptoms has been reported during or after antibacterial therapy.^[Ref]

Gastrointestinal side effects have included diarrhea (up to 15%), nausea (up to 6%), abdominal pain (2%), dyspepsia (up to 2%), and vomiting (1%). Flatulence, pseudomembranous colitis, oral moniliasis, anorexia, constipation, dry mouth, eructation, flatulence, gastrointestinal disorder, increased appetite, stomatitis, and taste perversion have been reported in less than 1% of patients. Cephalosporins as a class have been associated with colitis.^[Ref]

Dermatologic

Dermatologic side effects have included pruritus, rash, sweating, and urticaria in less than 1% of patients. Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis have been reported during postmarketing experience.^[Ref]

Hypersensitivity

Hypersensitivity side effects have included allergic reaction (less than 1%). Anaphylaxis and anaphylactic shock been reported during postmarketing experience. Cephalosporins as a class have been associated with allergic reactions, anaphylaxis, Stevens-Johnson syndrome, serum sickness-like reaction, toxic epidermal necrolysis, and erythema multiforme. Patients allergic to other beta-lactam antibiotics may be allergic to cefditoren.^[Ref]

Genitourinary

Genitourinary side effects have included vaginal moniliasis (up to 6%), hematuria (up to 3.1%), and increased urine white blood cells (2.3%). Proteinuria, leukorrhea, and vaginitis have been reported in less than 1% of patients.^[Ref]

Hematologic

Hematologic side effects have included decreased hematocrit (up to 2.2%). Increased coagulation time, thrombocythemia, leukopenia, increased/decreased white blood cells, increased eosinophils, decreased neutrophils, increased lymphocytes, increased platelet count, decreased albumin, and decreased hemoglobin have been reported in less than 1% of patients. Thrombocytopenia has been reported during postmarketing experience. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, neutropenia, pancytopenia, and agranulocytosis.^[Ref]

Hepatic

Hepatic side effects have included abnormal liver function tests, increased SGPT/ALT, and increased SGOT/AST in less than 1% of patients. Cephalosporins as a class have been associated with hepatic dysfunction (including cholestasis) and elevated bilirubin.^[Ref]

Nervous system

Nervous system side effects have included headache (up to 3%). Somnolence and dizziness have been reported in less than 1% of patients. Several cephalosporins have been associated with seizures, particularly when inappropriately high doses were administered to renally impaired patients. Cephalosporins as a class have been associated with reversible hyperactivity and hypertonia.^[Ref]

Metabolic

Thirty percent and 46% decreases in serum carnitine levels were reported in patients after cefditoren 200 mg twice daily for 14 days and 400 mg twice daily for 14 days, respectively. Carnitine levels normalized within 7 days after discontinuation.^[Ref]

Metabolic side effects have included increased glucose (up to 1.8%). Decreased sodium, increased potassium, decreased chloride, decreased inorganic phosphorus, decreased calcium, increased cholesterol, hyperglycemia, and thirst have been reported in less than 1% of patients. Pivalate-containing compounds have been associated with clinically significant carnitine deficiency during prolonged use due to increased renal excretion of carnitine. Short-term treatment with cefditoren has not been associated with clinical effects of decreased carnitine levels. Cephalosporins as a class have been associated with elevated alkaline phosphatase and lactate dehydrogenase.^[Ref]

Renal

Renal side effects have included increased BUN (less than 1%). Acute renal failure has been reported during postmarketing experience. Cephalosporins as a class have been associated with increased creatinine, renal dysfunction, and toxic nephropathy.^[Ref]

Respiratory

Respiratory side effects have included asthma, pharyngitis, rhinitis, and sinusitis in less than 1% of patients. Interstitial pneumonia and acute eosinophilic pneumonia have been reported during postmarketing experience.^[Ref]

Psychiatric

Psychiatric side effects have included abnormal dreams, insomnia, and nervousness in less than 1% of patients.^[Ref]

Other

Other side effects have included asthenia, face edema, fever, fungal infection, peripheral edema, and pain in less than 1% of patients. Cephalosporins as a class have been associated with drug fever, superinfection, positive direct Coombs' test, and false-positive test for urinary glucose.^[Ref]

Musculoskeletal

Musculoskeletal side effects have included myalgia (less than 1%). Arthralgia has been reported during postmarketing experience.^[Ref]

Not all side effects for cefditoren may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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