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Captopril Side Effects

In Summary

More frequently reported side effects include: cough and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to captopril: oral liquid, oral tablet

Along with its needed effects, captopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking captopril:

Less Common

Rare

  • Arm, back, or jaw pain
  • bloody urine
  • chest discomfort
  • chest tightness or heaviness
  • decreased blood pressure
  • decreased or increased frequency or amount of urine
  • dilated neck veins
  • increased thirst
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • low blood pressure
  • lower back or side pain
  • nausea
  • paleness or cold feeling in the fingertips and toes
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • tingling or pain in the fingers or toes when exposed to cold temperatures
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Incidence Not Known

  • Bleeding gums
  • bloody, black, or tarry stools
  • blurred vision
  • chills
  • confusion
  • cough
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • high fever
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising

Some side effects of captopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Change in taste
  • feeling of warmth
  • itching skin
  • loss of taste
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to captopril: compounding powder, oral tablet

General

The most common side effect is rash.[Ref]

Dermatologic

Very common (10% or more): Rash (up to 13.1%)

Common (1% to 10%): Pruritus, alopecia

Uncommon (0.1% to 1%): Angioedema

Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, erythroderma, pemphigoid reactions, exfoliative dermatitis[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, abdominal pain, dry mouth, diarrhea, constipation, gastric irritation

Rare (0.01% to 0.1%): Stomatitis/aphthous ulceration, mouth ulcers, intestinal angioedema

Very rare (less than 0.01%): Glossitis, peptic ulcer, pancreatitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, taste impairment, loss of taste

Rare (0.01% to 0.1%): Paresthesia, headache, drowsiness

Very rare (less than 0.01%): Cerebrovascular incidents

Frequency not reported: Syncope, ataxia, somnolence[Ref]

Respiratory

Common (1% to 10%): Cough, dyspnea

Rare (0.01% to 0.1%): Bronchospasm

Very rare (less than 0.01%): Rhinitis, allergic alveolitis/eosinophilic pneumonia[Ref]

Cardiovascular

Common (1% to 10%): Hypotension

Uncommon (0.1% to 1%): Tachycardia or tachyarrhythmia, angina pectoris, palpitations, Raynaud's syndrome, flushing, pallor, myocardial infarction, congestive heart failure

Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock

Frequency not reported: Rhythm disturbances, orthostatic hypotension[Ref]

Genitourinary

Common (1% to 10%): Proteinuria

Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency

Rare (less than 0.1%): Impotence[Ref]

Psychiatric

Common (1% to 10%): Sleep disorder

Rare (0.01% to 0.1%): Loss of libido

Very rare (less than 0.01%): Confusion, depression

Frequency not reported: Nervousness[Ref]

Other

Uncommon (0.1% to 1%): Chest pain, fatigue, malaise

Very rare (less than 0.01%): Gynecomastia, fever

Frequency not reported: Asthenia, alkaline phosphatase elevated[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, acute renal failure, nephrotic syndrome

Very rare (less than 0.01%): BUN elevated, serum creatinine elevated

Frequency not reported: Glomerulopathy[Ref]

Metabolic

Rare (0.01% to 0.1%): Anorexia, weight loss, loss of appetite

Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased

Frequency not reported: Hyponatremia[Ref]

Ocular

Rare (0.01% to 0.1%): Disturbed vision, dry eye, itchy eye

Very rare (less than 0.01%): Blurred vision[Ref]

Hematologic

Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, eosinophilia, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate elevated[Ref]

Hepatic

Very rare (less than 0.01%): Liver enzymes elevated, bilirubin elevated, impaired hepatic function, cholestasis, hepatitis

Frequency not reported: Jaundice[Ref]

Immunologic

Very rare (less than 0.01%): Autoimmune disease, positive antinuclear antibody titer

Frequency not reported: Serum sickness-like syndrome, anaphylactoid reactions[Ref]

Musculoskeletal

Very rare (less than 0.01%): Myalgia, arthralgia

Frequency not reported: Myasthenia[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Capoten (captopril)." Bristol-Myers Squibb, Princeton, NJ.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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