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Captopril Side Effects

Medically reviewed by Last updated on Oct 26, 2023.

Applies to captopril: oral tablet.


Oral route (Tablet)

When pregnancy is detected, discontinue captopril as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects of Captopril

Along with its needed effects, captopril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking captopril:

Less common


Incidence not known

Other side effects of Captopril

Some side effects of captopril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to captopril: compounding powder, oral tablet.


The most common side effect is rash.[Ref]


Very common (10% or more): Rash (up to 13.1%)

Common (1% to 10%): Pruritus, alopecia

Uncommon (0.1% to 1%): Angioedema

Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, erythroderma, pemphigoid reactions, exfoliative dermatitis[Ref]


Common (1% to 10%): Nausea, vomiting, abdominal pain, dry mouth, diarrhea, constipation, gastric irritation

Rare (0.01% to 0.1%): Stomatitis/aphthous ulceration, mouth ulcers, intestinal angioedema

Very rare (less than 0.01%): Glossitis, peptic ulcer, pancreatitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, taste impairment, loss of taste

Rare (0.01% to 0.1%): Paresthesia, headache, drowsiness

Very rare (less than 0.01%): Cerebrovascular incidents

Frequency not reported: Syncope, ataxia, somnolence[Ref]


Common (1% to 10%): Cough, dyspnea

Rare (0.01% to 0.1%): Bronchospasm

Very rare (less than 0.01%): Rhinitis, allergic alveolitis/eosinophilic pneumonia[Ref]


Common (1% to 10%): Hypotension

Uncommon (0.1% to 1%): Tachycardia or tachyarrhythmia, angina pectoris, palpitations, Raynaud's syndrome, flushing, pallor, myocardial infarction, congestive heart failure

Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock

Frequency not reported: Rhythm disturbances, orthostatic hypotension[Ref]


Common (1% to 10%): Proteinuria

Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency

Rare (less than 0.1%): Impotence[Ref]


Common (1% to 10%): Sleep disorder

Rare (0.01% to 0.1%): Loss of libido

Very rare (less than 0.01%): Confusion, depression

Frequency not reported: Nervousness[Ref]


Uncommon (0.1% to 1%): Chest pain, fatigue, malaise

Very rare (less than 0.01%): Gynecomastia, fever

Frequency not reported: Asthenia, alkaline phosphatase elevated[Ref]


Uncommon (0.1% to 1%): Renal insufficiency, acute renal failure, nephrotic syndrome

Very rare (less than 0.01%): BUN elevated, serum creatinine elevated

Frequency not reported: Glomerulopathy[Ref]


Rare (0.01% to 0.1%): Anorexia, weight loss, loss of appetite

Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased

Frequency not reported: Hyponatremia[Ref]


Rare (0.01% to 0.1%): Disturbed vision, dry eye, itchy eye

Very rare (less than 0.01%): Blurred vision[Ref]


Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, eosinophilia, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate elevated[Ref]


Very rare (less than 0.01%): Liver enzymes elevated, bilirubin elevated, impaired hepatic function, cholestasis, hepatitis

Frequency not reported: Jaundice[Ref]


Very rare (less than 0.01%): Autoimmune disease, positive antinuclear antibody titer

Frequency not reported: Serum sickness-like syndrome, anaphylactoid reactions[Ref]


Very rare (less than 0.01%): Myalgia, arthralgia

Frequency not reported: Myasthenia[Ref]

Frequently asked questions


1. Product Information. Capoten (captopril). Bristol-Myers Squibb. 2002;PROD.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.