Capozide 25/25 Side Effects
Generic name: captopril / hydrochlorothiazide
Medically reviewed by Drugs.com. Last updated on Mar 2, 2024.
Note: This document provides detailed information about Capozide 25/25 Side Effects associated with captopril / hydrochlorothiazide. Some dosage forms listed on this page may not apply specifically to the brand name Capozide 25/25.
Applies to captopril / hydrochlorothiazide: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Use in Pregnancy. When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus.
When pregnancy is detected, captopril and hydrochlorothiazide should be discontinued as soon as possible.
Serious side effects of Capozide 25/25
Along with its needed effects, captopril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking captopril / hydrochlorothiazide:
More common
- black, tarry stools
- chest pain
- chills
- cough
- fever
- painful or difficult urination
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
Less common
- blurred vision
- cloudy urine
- confusion
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast, pounding, or irregular heartbeat or pulse
- sweating
Rare
- arm, back, or jaw pain or discomfort
- bloody urine
- chest discomfort, tightness, or heaviness
- decreased blood pressure
- decreased frequency or amount of urine
- dilated neck veins
- increased need to urinate
- increased thirst
- irregular breathing
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- lower back or side pain
- nausea
- paleness or cold feeling in fingertips and toes
- passing urine more often
- problems in urination or increase in amount of urine
- swelling of the face, fingers, feet, or lower legs
- tingling or pain in the fingers or toes when exposed to cold
- vomiting
- weight gain
incidence not known
- persistent non-healing sore
- pink growth
- reddish patch or irritated area
- shiny bump
- white, yellow or waxy scar-like area
Other side effects of Capozide 25/25
Some side effects of captopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- difficulty in moving
- itching skin, rash
- muscle pain or stiffness
- pain in joints
Less common
- change or loss of taste
For healthcare professionals
Applies to captopril / hydrochlorothiazide: oral tablet.
Gastrointestinal
Captopril:
- Common (1% to 10%): Nausea, vomiting, gastric irritations, abdominal pain, diarrhea, constipation, dry mouth, peptic ulcer, aphthous ulcers
- Rare (0.01% to 0.1%): Intestinal angioedema
- Very rare (less than 0.01%): Glossitis, pancreatitis
- Frequency not reported: Dyspepsia
Hydrochlorothiazide:
- Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis, cramping, nausea, vomiting[Ref]
Nervous system
Captopril:
- Common (1% to 10%): Taste impairment, dizziness, headache, paresthesias
- Rare (0.01% to 0.1%): Drowsiness
- Very rare (less than 0.01%): Cerebrovascular incidents
- Frequency not reported: Syncope, ataxia, somnolence
Hydrochlorothiazide:
- Frequency not reported: Paresthesia, lightheadedness, vertigo, dizziness, headache[Ref]
Dermatologic
Captopril:
- Common (1% to 10%): Pruritus, rash, alopecia
- Uncommon (0.1% to 1%): Angioedema
- Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, pemphigoid reactions, erythroderma, exfoliative dermatitis
Hydrochlorothiazide:
- Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, purpura[Ref]
Other
Captopril:
- Common (1% to 10%): Chest pain, malaise, fatigue
- Very rare (less than 0.01%): Gynecomastia, fever
- Frequency not reported: Asthenia
Hydrochlorothiazide:
- Frequency not reported: Fever, weakness[Ref]
Cardiovascular
Captopril:
- Common (1% to 10%): Tachycardia, palpitations
- Uncommon (0.1% to 1%): Tachyarrhythmia, angina pectoris, hypotension, Raynaud's syndrome, flush, pallor, myocardial infarction, congestive heart failure
- Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock
- Frequency not reported: Rhythm disturbances, orthostatic hypotension
Hydrochlorothiazide:
- Frequency not reported: Postural hypotension, cardiac arrhythmias, vasculitis[Ref]
Respiratory
Captopril:
- Common (1% to 10%): Cough, dyspnea
- Very rare (less than 0.01%): Bronchospasm, rhinitis, allergic alveolitis/eosinophilic pneumonia
Hydrochlorothiazide:
- Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]
Psychiatric
Captopril:
- Common (1% to 10%): Sleep disorders, insomnia
- Very rare (less than 0.01%): Confusion, depression
- Frequency not reported: Nervousness
Hydrochlorothiazide:
- Frequency not reported: Restlessness, depression, sleep disturbances[Ref]
Genitourinary
Captopril:
- Common (1% to 10%): Proteinuria
- Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency
- Very rare (less than 0.01%): Impotence
Hydrochlorothiazide:
- Frequency not reported: Glycosuria[Ref]
Metabolic
Captopril:
- Common (1% to 10%): Anorexia
- Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased
- Frequency not reported: Symptomatic hyponatremia
Hydrochlorothiazide:
- Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased, loss of appetite[Ref]
Renal
Captopril:
- Uncommon (0.1% to 1%): Renal insufficiency, renal failure, nephrotic syndrome
- Very rare (less than 0.01%): BUN increased, serum creatinine increased
Hydrochlorothiazide:
- Frequency not reported: Renal dysfunction, interstitial nephritis[Ref]
Hematologic
Captopril:
- Uncommon (0.1% to 1%): Eosinophilia
- Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate increased
Hydrochlorothiazide:
- Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression[Ref]
Immunologic
Captopril:
- Uncommon (0.1% to 1%): Antinuclear antibody positive
- Very rare (less than 0.01%): Autoimmune diseases
- Frequency not reported: Anaphylactoid reactions
Hydrochlorothiazide:
- Frequency not reported: Anaphylactic reactions[Ref]
Hepatic
Captopril:
- Very rare (less than 0.01%): Impaired hepatic function and cholestasis including jaundice, hepatitis including necrosis, elevated liver enzymes and bilirubin
Hydrochlorothiazide:
- Frequency not reported: Intrahepatic cholestatic jaundice[Ref]
Musculoskeletal
Captopril:
- Very rare (less than 0.01%): Myalgia, arthralgia
- Frequency not reported: Myasthenia
Hydrochlorothiazide:
- Frequency not reported: Muscle spasm[Ref]
Ocular
Captopril:
- Very rare (less than 0.01%): Blurred vision
Hydrochlorothiazide:
- Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, secondary acute angle-closure glaucoma[Ref]
References
1. "Product Information. Capozide 25/15 (captopril-hydrochlorothiazide)." Bristol-Myers Squibb
2. Cerner Multum, Inc. "UK Summary of Product Characteristics."
More about Capozide 25 / 25 (captopril / hydrochlorothiazide)
- Check interactions
- Compare alternatives
- Reviews (1)
- Drug images
- Dosage information
- During pregnancy
- Drug class: ACE inhibitors with thiazides
Patient resources
Other brands
Capozide 25/15, Capozide 50/15, Capozide 50/25
Professional resources
Related treatment guides
Further information
Capozide 25/25 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.