Capozide 25/25 Side Effects

Generic name: captopril / hydrochlorothiazide

Medically reviewed by Drugs.com. Last updated on Aug 3, 2024.

Note: This document provides detailed information about Capozide 25/25 Side Effects associated with captopril / hydrochlorothiazide. Some dosage forms listed on this page may not apply specifically to the brand name Capozide 25/25.

Applies to captopril / hydrochlorothiazide: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Check with your doctor right away if you have large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs. These may be symptoms of a condition called angioedema.

Check with your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may also occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine and call your doctor right away.

This medicine may cause a serious type of allergic reaction, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, trouble breathing, or weakness or heaviness of the legs. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Serious side effects of Capozide 25/25

Along with its needed effects, captopril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking captopril / hydrochlorothiazide:

incidence not known

• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• shiny bump
• white, yellow or waxy scar-like area

Other side effects of Capozide 25/25

Some side effects of captopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to captopril / hydrochlorothiazide: oral tablet.

Gastrointestinal adverse events

Captopril:

• Common (1% to 10%): Nausea, vomiting, gastric irritations, abdominal pain, diarrhea, constipation, dry mouth, peptic ulcer, aphthous ulcers
• Rare (0.01% to 0.1%): Intestinal angioedema
• Very rare (less than 0.01%): Glossitis, pancreatitis
• Frequency not reported: Dyspepsia

Hydrochlorothiazide:

• Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis, cramping, nausea, vomiting^[Ref]

Nervous system

Captopril:

• Common (1% to 10%): Taste impairment, dizziness, headache, paresthesias
• Rare (0.01% to 0.1%): Drowsiness
• Very rare (less than 0.01%): Cerebrovascular incidents
• Frequency not reported: Syncope, ataxia, somnolence

Hydrochlorothiazide:

• Frequency not reported: Paresthesia, lightheadedness, vertigo, dizziness, headache^[Ref]

Dermatologic

Captopril:

• Common (1% to 10%): Pruritus, rash, alopecia
• Uncommon (0.1% to 1%): Angioedema
• Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, pemphigoid reactions, erythroderma, exfoliative dermatitis

Hydrochlorothiazide:

• Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, purpura^[Ref]

Other

Captopril:

• Common (1% to 10%): Chest pain, malaise, fatigue
• Very rare (less than 0.01%): Gynecomastia, fever
• Frequency not reported: Asthenia

Hydrochlorothiazide:

• Frequency not reported: Fever, weakness^[Ref]

Cardiovascular

Captopril:

• Common (1% to 10%): Tachycardia, palpitations
• Uncommon (0.1% to 1%): Tachyarrhythmia, angina pectoris, hypotension, Raynaud's syndrome, flush, pallor, myocardial infarction, congestive heart failure
• Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock
• Frequency not reported: Rhythm disturbances, orthostatic hypotension

Hydrochlorothiazide:

• Frequency not reported: Postural hypotension, cardiac arrhythmias, vasculitis^[Ref]

Respiratory

Captopril:

• Common (1% to 10%): Cough, dyspnea
• Very rare (less than 0.01%): Bronchospasm, rhinitis, allergic alveolitis/eosinophilic pneumonia

Hydrochlorothiazide:

• Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Psychiatric

Captopril:

• Common (1% to 10%): Sleep disorders, insomnia
• Very rare (less than 0.01%): Confusion, depression
• Frequency not reported: Nervousness

Hydrochlorothiazide:

• Frequency not reported: Restlessness, depression, sleep disturbances^[Ref]

Genitourinary

Captopril:

• Common (1% to 10%): Proteinuria
• Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency
• Very rare (less than 0.01%): Impotence

Hydrochlorothiazide:

• Frequency not reported: Glycosuria^[Ref]

Metabolic

Captopril:

• Common (1% to 10%): Anorexia
• Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased
• Frequency not reported: Symptomatic hyponatremia

Hydrochlorothiazide:

• Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased, loss of appetite^[Ref]

Renal

Captopril:

• Uncommon (0.1% to 1%): Renal insufficiency, renal failure, nephrotic syndrome
• Very rare (less than 0.01%): BUN increased, serum creatinine increased

Hydrochlorothiazide:

• Frequency not reported: Renal dysfunction, interstitial nephritis^[Ref]

Hematologic

Captopril:

• Uncommon (0.1% to 1%): Eosinophilia
• Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate increased

Hydrochlorothiazide:

• Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression^[Ref]

Immunologic

Captopril:

• Uncommon (0.1% to 1%): Antinuclear antibody positive
• Very rare (less than 0.01%): Autoimmune diseases
• Frequency not reported: Anaphylactoid reactions

Hydrochlorothiazide:

• Frequency not reported: Anaphylactic reactions^[Ref]

Hepatic

Captopril:

• Very rare (less than 0.01%): Impaired hepatic function and cholestasis including jaundice, hepatitis including necrosis, elevated liver enzymes and bilirubin

Hydrochlorothiazide:

• Frequency not reported: Intrahepatic cholestatic jaundice^[Ref]

Musculoskeletal

Captopril:

• Very rare (less than 0.01%): Myalgia, arthralgia
• Frequency not reported: Myasthenia

Hydrochlorothiazide:

• Frequency not reported: Muscle spasm^[Ref]

Ocular

Captopril:

• Very rare (less than 0.01%): Blurred vision

Hydrochlorothiazide:

• Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, secondary acute angle-closure glaucoma^[Ref]

See also:

Further information

Capozide 25/25 side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

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