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Captopril / Hydrochlorothiazide Dosage

Medically reviewed by Drugs.com. Last updated on Feb 27, 2024.

Applies to the following strengths: 25 mg-15 mg; 25 mg-25 mg; 50 mg-15 mg; 50 mg-25 mg

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Hypertension

Initial dose: Captopril 25 mg-Hydrochlorothiazide 15 mg orally once a day 1 hour before meals
Maximum dose: Captopril 150 mg-Hydrochlorothiazide 50 mg per day

Comments: The full effect of a given dose may not be attained for 6 to 8 weeks; dose adjustments should be made at 6 week intervals, unless the clinical situation demands more rapid adjustment.

Use: Treatment of hypertension as initial therapy or substituted for previously titrated doses of the individual components.

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 to less than 90 mL/min): Once the desired therapeutic effect has been achieved, increase the dose interval or decrease the total daily dose until the minimum effective dose is achieved.
Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended

If progressive renal impairment becomes evident as indicated by a rising BUN or nonprotein nitrogen: Consider withholding or discontinuing this drug

Liver Dose Adjustments

Use with caution

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Should be taken 1 hour before meals.

Storage requirements: Protect from light.

Monitoring:


Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.