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Capozide 25/15 Side Effects

Generic name: captopril / hydrochlorothiazide

Medically reviewed by Last updated on Feb 16, 2023.

Note: This document contains side effect information about captopril / hydrochlorothiazide. Some dosage forms listed on this page may not apply to the brand name Capozide 25/15.

Applies to captopril / hydrochlorothiazide: oral tablet.


Oral route (Tablet)

Use in PregnancyWhen used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, captopril and hydrochlorothiazide should be discontinued as soon as possible.

Serious side effects of Capozide 25/15

Along with its needed effects, captopril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking captopril / hydrochlorothiazide:

More common

  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • fever
  • painful or difficult urination
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Blurred vision
  • cloudy urine
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • sweating


  • Arm, back, or jaw pain or discomfort
  • bloody urine
  • chest discomfort, tightness, or heaviness
  • decreased blood pressure
  • decreased frequency or amount of urine
  • dilated neck veins
  • increased need to urinate
  • increased thirst
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • lower back or side pain
  • nausea
  • paleness or cold feeling in fingertips and toes
  • passing urine more often
  • problems in urination or increase in amount of urine
  • swelling of the face, fingers, feet, or lower legs
  • tingling or pain in the fingers or toes when exposed to cold
  • vomiting
  • weight gain

incidence not known

  • Persistent non-healing sore
  • pink growth
  • reddish patch or irritated area
  • shiny bump
  • white, yellow or waxy scar-like area

Other side effects of Capozide 25/15

Some side effects of captopril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty in moving
  • itching skin, rash
  • muscle pain or stiffness
  • pain in joints

Less common

  • Change or loss of taste

For Healthcare Professionals

Applies to captopril / hydrochlorothiazide: oral tablet.



Common (1% to 10%): Nausea, vomiting, gastric irritations, abdominal pain, diarrhea, constipation, dry mouth, peptic ulcer, aphthous ulcers

Rare (0.01% to 0.1%): Intestinal angioedema

Very rare (less than 0.01%): Glossitis, pancreatitis

Frequency not reported: Dyspepsia


Frequency not reported: Sialadenitis, gastric irritation, diarrhea, constipation, pancreatitis, cramping, nausea, vomiting[Ref]

Nervous system


Common (1% to 10%): Taste impairment, dizziness, headache, paresthesias

Rare (0.01% to 0.1%): Drowsiness

Very rare (less than 0.01%): Cerebrovascular incidents

Frequency not reported: Syncope, ataxia, somnolence


Frequency not reported: Paresthesia, lightheadedness, vertigo, dizziness, headache[Ref]



Common (1% to 10%): Pruritus, rash, alopecia

Uncommon (0.1% to 1%): Angioedema

Very rare (less than 0.01%): Urticaria, Stevens-Johnson syndrome, erythema multiforme, photosensitivity, pemphigoid reactions, erythroderma, exfoliative dermatitis


Frequency not reported: Cutaneous vasculitis, photosensitivity reactions, rash, cutaneous lupus erythematosus-like reactions, reactivation of cutaneous lupus erythematosus, urticaria, toxic epidermal necrolysis, purpura[Ref]



Common (1% to 10%): Chest pain, malaise, fatigue

Very rare (less than 0.01%): Gynecomastia, fever

Frequency not reported: Asthenia


Frequency not reported: Fever, weakness[Ref]



Common (1% to 10%): Tachycardia, palpitations

Uncommon (0.1% to 1%): Tachyarrhythmia, angina pectoris, hypotension, Raynaud's syndrome, flush, pallor, myocardial infarction, congestive heart failure

Very rare (less than 0.01%): Cardiac arrest, cardiogenic shock

Frequency not reported: Rhythm disturbances, orthostatic hypotension


Frequency not reported: Postural hypotension, cardiac arrhythmias, vasculitis[Ref]



Common (1% to 10%): Cough, dyspnea

Very rare (less than 0.01%): Bronchospasm, rhinitis, allergic alveolitis/eosinophilic pneumonia


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema[Ref]



Common (1% to 10%): Sleep disorders, insomnia

Very rare (less than 0.01%): Confusion, depression

Frequency not reported: Nervousness


Frequency not reported: Restlessness, depression, sleep disturbances[Ref]



Common (1% to 10%): Proteinuria

Uncommon (0.1% to 1%): Polyuria, oliguria, urinary frequency

Very rare (less than 0.01%): Impotence


Frequency not reported: Glycosuria[Ref]



Common (1% to 10%): Anorexia

Very rare (less than 0.01%): Hyperkalemia, hypoglycemia, serum potassium increased, serum sodium decreased

Frequency not reported: Symptomatic hyponatremia


Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, electrolyte imbalance, hyponatremia, hypokalemia, cholesterol increased, triglycerides increased, loss of appetite[Ref]



Uncommon (0.1% to 1%): Renal insufficiency, renal failure, nephrotic syndrome

Very rare (less than 0.01%): BUN increased, serum creatinine increased


Frequency not reported: Renal dysfunction, interstitial nephritis[Ref]



Uncommon (0.1% to 1%): Eosinophilia

Very rare (less than 0.01%): Neutropenia/agranulocytosis, pancytopenia, anemia, thrombocytopenia, lymphadenopathy, hemoglobin decreased, hematocrit decreased, leukocytes decreased, thrombocytes decreased, erythrocyte sedimentation rate increased


Frequency not reported: Leukopenia, neutropenia/agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, bone marrow depression[Ref]



Uncommon (0.1% to 1%): Antinuclear antibody positive

Very rare (less than 0.01%): Autoimmune diseases

Frequency not reported: Anaphylactoid reactions


Frequency not reported: Anaphylactic reactions[Ref]



Very rare (less than 0.01%): Impaired hepatic function and cholestasis including jaundice, hepatitis including necrosis, elevated liver enzymes and bilirubin


Frequency not reported: Intrahepatic cholestatic jaundice[Ref]



Very rare (less than 0.01%): Myalgia, arthralgia

Frequency not reported: Myasthenia


Frequency not reported: Muscle spasm[Ref]



Very rare (less than 0.01%): Blurred vision


Frequency not reported: Xanthopsia, transient blurred vision, acute myopia, secondary acute angle-closure glaucoma[Ref]


1. "Product Information. Capozide 25/15 (captopril-hydrochlorothiazide)." Bristol-Myers Squibb

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.