Benazepril / Hydrochlorothiazide Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 8, 2024.

Applies to benazepril / hydrochlorothiazide: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Discontinue benazepril hydrochloride/hydrochlorothiazide as soon as possible upon awareness of a pregnancy.

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Serious side effects

Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:

Less common side effects

• blurred vision
• confusion
• decreased urination
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• dry mouth
• fast, slow, or irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in the hands or feet
• rapid breathing
• seizures
• sunken eyes
• sweating
• thirst
• trembling
• unusual tiredness or weakness
• weakness and heaviness of the legs
• wrinkled skin

Rare side effects

• black, tarry stools
• bloating
• burning, crawling, itching, numbness, prickling, "pins and needles" , or tingling feelings
• chest pain
• chills
• constipation
• cough or hoarseness
• darkened urine
• diarrhea
• dizziness or lightheadedness
• feeling of constant movement of self or surroundings
• fever
• headache
• indigestion
• loss of appetite
• lower back or side pain
• nausea
• painful or difficult urination
• pains in the stomach or side, possibly radiating to the back
• persistent non-healing sore
• pink growth
• reddish patch or irritated area
• sensation of spinning
• shiny bump
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swollen glands
• trouble breathing
• unusual bleeding or bruising
• vomiting
• white, yellow or waxy scar-like area
• yellow eyes or skin

Other side effects

Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• cough
• decreased interest in sexual intercourse
• excessive muscle tone
• feeling of constant movement of self or surroundings
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• muscle stiffness
• muscle tension or tightness
• sensation of spinning
• sleepiness or unusual drowsiness

Rare side effects

• blistering, peeling, loosening of the skin
• diarrhea
• hives or welts, itching, skin rash
• increased sensitivity of skin to sunlight
• joint or muscle pain
• pinpoint red or purple spots on the skin
• redness of the skin
• redness or other discoloration of the skin
• red irritated eyes
• red skin lesions, often with a purple center
• severe sunburn

For healthcare professionals

Applies to benazepril / hydrochlorothiazide: oral tablet.

General adverse events

The most common side effects were dizziness, fatigue, headache, and cough.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence
• Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia

Hydrochlorothiazide:

• Postmarketing reports: Lightheadedness, headache, paresthesia^[Ref]

Respiratory

• Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis
• Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration

Benazepril:

• Postmarketing reports: Eosinophilic pneumonitis

Hydrochlorothiazide:

• Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Other

• Common (1% to 10%): Fatigue, vertigo, flu syndrome
• Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills

Hydrochlorothiazide:

• Postmarketing reports: Vertigo, weakness, pyrexia, asthenia^[Ref]

Genitourinary

• Common (1% to 10%): Impotence, urinary frequency
• Uncommon (0.1% to 1%): Urinary tract infection^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea
• Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder

Hydrochlorothiazide:

• Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain
• Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis

Hydrochlorothiazide:

• Postmarketing reports: Muscle spasm^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia

Benazepril:

• Postmarketing reports: Stevens-Johnson syndrome, pemphigus

Hydrochlorothiazide:

• Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams

Hydrochlorothiazide:

• Postmarketing reports: Restlessness^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia

Hydrochlorothiazide:

• Postmarketing reports: Necrotizing angiitis^[Ref]

Ocular

• Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis

Hydrochlorothiazide:

• Postmarketing reports: Transient blurred vision, xanthopsia^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia

Hydrochlorothiazide:

• Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Infection

Hydrochlorothiazide:

• Postmarketing reports: Anaphylactoid reactions^[Ref]

Renal

• Frequency not reported: Serum creatinine increased, BUN increased^[Ref]

Hematologic

Benazepril:

• Postmarketing reports: Hemolytic anemia, thrombocytopenia

Hydrochlorothiazide:

• Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia^[Ref]

Hepatic

Benazepril:

• Postmarketing reports: Pancreatitis

Hydrochlorothiazide:

• Postmarketing reports: Intrahepatic cholestatic jaundice^[Ref]

Endocrine

Hydrochlorothiazide:

• Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia^[Ref]

Further information

Benazepril/hydrochlorothiazide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer