Benazepril / Hydrochlorothiazide Side Effects

Medically reviewed by Drugs.com. Last updated on Jan 25, 2025.

Applies to benazepril / hydrochlorothiazide: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby, especially in your second or third trimester. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. You may need to stop using this medicine.

You should not use this medicine together with sacubitril. Do not use this medicine and sacubitril/valsartan (Entresto®) within 36 hours of each other.

This medicine may cause serious allergic reactions including anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, lips, tongue, or throat while you are using this medicine.

Check with your doctor right away if you have a severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). Do not drive or do anything else that could be dangerous until you know how this medicine affects you. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using this medicine until you have talked to your doctor.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.

Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

This medicine may increase the amount of cholesterol and fats in your blood. If this condition occurs, your doctor may give you some medicines that can lower the amount of cholesterol and fats in the blood.

This medicine may affect your blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

Check with your doctor immediately if blurred vision, difficulty reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor (ophthalmologist) to check your eyes.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, trouble breathing, or weakness or heaviness of the legs. Do not use medicines, supplements, or salt substitutes containing potassium without first checking with your doctor.

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

This medicine may be less effective in black patients. Black patients also have an increased risk of swelling of the hands, arms, face, mouth, or throat. Talk with your doctor if you have concerns about this.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements, since they may tend to increase your blood pressure.

Serious side effects

Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:

Other side effects

Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to benazepril / hydrochlorothiazide: oral tablet.

General adverse events

The most common side effects were dizziness, fatigue, headache, and cough.^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence
• Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia

Hydrochlorothiazide:

• Postmarketing reports: Lightheadedness, headache, paresthesia^[Ref]

Respiratory

• Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis
• Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration

Benazepril:

• Postmarketing reports: Eosinophilic pneumonitis

Hydrochlorothiazide:

• Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema^[Ref]

Other

• Common (1% to 10%): Fatigue, vertigo, flu syndrome
• Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills

Hydrochlorothiazide:

• Postmarketing reports: Vertigo, weakness, pyrexia, asthenia^[Ref]

Genitourinary

• Common (1% to 10%): Impotence, urinary frequency
• Uncommon (0.1% to 1%): Urinary tract infection^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea
• Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder

Hydrochlorothiazide:

• Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation^[Ref]

Musculoskeletal

• Common (1% to 10%): Back pain
• Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis

Hydrochlorothiazide:

• Postmarketing reports: Muscle spasm^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia

Benazepril:

• Postmarketing reports: Stevens-Johnson syndrome, pemphigus

Hydrochlorothiazide:

• Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams

Hydrochlorothiazide:

• Postmarketing reports: Restlessness^[Ref]

Cardiovascular

• Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia

Hydrochlorothiazide:

• Postmarketing reports: Necrotizing angiitis^[Ref]

Ocular

• Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis

Hydrochlorothiazide:

• Postmarketing reports: Transient blurred vision, xanthopsia^[Ref]

Metabolic

• Uncommon (0.1% to 1%): Anorexia

Hydrochlorothiazide:

• Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Infection

Hydrochlorothiazide:

• Postmarketing reports: Anaphylactoid reactions^[Ref]

Renal

• Frequency not reported: Serum creatinine increased, BUN increased^[Ref]

Hematologic

Benazepril:

• Postmarketing reports: Hemolytic anemia, thrombocytopenia

Hydrochlorothiazide:

• Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia^[Ref]

Hepatic

Benazepril:

• Postmarketing reports: Pancreatitis

Hydrochlorothiazide:

• Postmarketing reports: Intrahepatic cholestatic jaundice^[Ref]

Endocrine

Hydrochlorothiazide:

• Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia^[Ref]

See also:

Further information

Benazepril/hydrochlorothiazide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer