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Benazepril / hydrochlorothiazide Side Effects

For the Consumer

Applies to benazepril / hydrochlorothiazide: oral tablet

Along with its needed effects, benazepril / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking benazepril / hydrochlorothiazide:

Less common
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, slow, or irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • rapid breathing
  • seizures
  • sunken eyes
  • sweating
  • thirst
  • trembling
  • unusual tiredness or weakness
  • weakness and heaviness of the legs
  • wrinkled skin

Some side effects of benazepril / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Cough
  • decreased interest in sexual intercourse
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • muscle stiffness
  • muscle tension or tightness
  • nausea
  • sensation of spinning
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to benazepril / hydrochlorothiazide: oral tablet

General

The most common side effects were dizziness, fatigue, headache, and cough.[Ref]

Nervous system

Common (1% to 10%): Dizziness, postural dizziness, headache, hypertonia, somnolence
Uncommon (0.1% to 1%): Paresthesia, taste perversion, tinnitus, syncope, hypesthesia

Hydrochlorothiazide:
Postmarketing reports: Lightheadedness, headache, paresthesia[Ref]

Respiratory

Common (1% to 10%): Cough, upper respiratory infection, rhinitis, sinusitis
Uncommon (0.1% to 1%): Epistaxis, bronchitis, voice alteration

Benazepril:
Postmarketing reports: Eosinophilic pneumonitis

Hydrochlorothiazide:
Postmarketing reports: Respiratory distress, pneumonitis, pulmonary edema[Ref]

Other

Common (1% to 10%): Fatigue, vertigo, flu syndrome
Uncommon (0.1% to 1%): Asthenia, chest pain, fever, chills

Hydrochlorothiazide:
Postmarketing reports: Vertigo, weakness, pyrexia, asthenia[Ref]

Genitourinary

Common (1% to 10%): Impotence, urinary frequency
Uncommon (0.1% to 1%): Urinary tract infection[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Uncommon (0.1% to 1%): Vomiting, diarrhea, dyspepsia, constipation, dry mouth, abdominal pain, gastroenteritis, flatulence, tooth disorder

Hydrochlorothiazide:
Postmarketing reports: Pancreatitis, small bowel angioedema, sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation[Ref]

Musculoskeletal

Common (1% to 10%): Back pain
Uncommon (0.1% to 1%): Arthralgia, myalgia, neck pain, arthritis

Hydrochlorothiazide:
Postmarketing reports: Muscle spasm[Ref]

Dermatologic

Uncommon (0.1% to 1%): Rash, sweating, photosensitivity, pruritus, alopecia

Benazepril:
Postmarketing reports: Stevens-Johnson syndrome, pemphigus

Hydrochlorothiazide:
Postmarketing reports: Purpura, urticaria, rash, photosensitivity, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis[Ref]

Psychiatric

Uncommon (0.1% to 1%): Insomnia, nervousness, libido decreased, abnormal dreams

Hydrochlorothiazide:
Postmarketing reports: Restlessness[Ref]

Cardiovascular

Uncommon (0.1% to 1%): Palpitations, flushing, peripheral vascular disorder, tachycardia

Hydrochlorothiazide:
Postmarketing reports: Necrotizing angiitis[Ref]

Ocular

Uncommon (0.1% to 1%): Abnormal vision, retinal disorder, conjunctivitis

Hydrochlorothiazide:
Postmarketing reports: Transient blurred vision, xanthopsia[Ref]

Metabolic

Uncommon (0.1% to 1%): Anorexia

Hydrochlorothiazide:
Postmarketing reports: Anorexia, hyperglycemia, glycosuria, hyperuricemia[Ref]

Immunologic

Uncommon (0.1% to 1%): Infection

Hydrochlorothiazide:
Postmarketing reports: Anaphylactoid reactions[Ref]

Renal

Frequency not reported: Serum creatinine increased, BUN increased[Ref]

Hematologic

Benazepril:
Postmarketing reports: Hemolytic anemia, thrombocytopenia

Hydrochlorothiazide:
Postmarketing reports: Aplastic anemia, agranulocytosis, leukopenia, neutropenia, thrombocytopenia[Ref]

Hepatic

Benazepril:
Postmarketing reports: Pancreatitis

Hydrochlorothiazide:
Postmarketing reports: Intrahepatic cholestatic jaundice[Ref]

Endocrine

Hydrochlorothiazide:
Postmarketing reports: Parathyroid gland changes with hypercalcemia and hypophosphatemia[Ref]

References

1. "Product Information. Lotensin HCT (benazepril-hydrochlorothiazide)." Ciba Pharmaceuticals, Summit, NJ.

Some side effects of benazepril / hydrochlorothiazide may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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