Benazepril / Hydrochlorothiazide Dosage

Medically reviewed by Drugs.com. Last updated on Jan 22, 2025.

Usual Adult Dose for Hypertension

Benazepril 5 to 20 mg-Hydrochlorothiazide 6.25 to 25 mg orally once a day

Maximum dose: Benazepril 20 mg-Hydrochlorothiazide 25 mg

Comments: May increase dose after 2 to 3 weeks as needed to achieve blood pressure goal.

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 to 90 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl 30 mL/min or less): Data not available

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended.
Severe liver dysfunction: Data not available

Precautions

US BOXED WARNING:

• FETAL TOXICITY: If pregnancy is detected, discontinue this drug as soon as possible. Drugs that act directly on the renin-angiotensin system (RAS) can cause injury and death to the developing fetus.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:

• Assess renal function and serum electrolytes prior to initiating therapy and periodically during treatment.
• Consider monitoring white blood cell counts in patients with collagen-vascular disease, especially if associated with impaired renal function.
• Monitor congestive heart failure patients closely for the first 2 weeks of treatment with this drug and following a dose increase of this drug or a concomitant diuretic.

Patient advice:

• Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.
• Advise patients to immediately report any signs or symptoms of angioedema (breathing difficulty or swelling of face, eyes, lips, or tongue) and to stop taking this drug until consulting a physician.
• Encourage patients to report any lightheadedness that may occur during treatment initiation and to stop taking this drug until consulting a physician if syncope occurs.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer