Hydrochlorothiazide and benazepril
Generic Name: hydrochlorothiazide and benazepril (HYE droe KLOR oh THY a zide and ben AZ e pril)
Brand Name: Lotensin HCT
Medically reviewed on October 2, 2017.
What is hydrochlorothiazide and benazepril?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril lowers blood pressure and also relieves symptoms of fluid retention.
Hydrochlorothiazide and benazepril is a combination medicine used to treat hypertension (high blood pressure).
Hydrochlorothiazide and benazepril may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.
You should not use this medicine if you are unable to urinate, if you have ever had angioedema, or if you are allergic to sulfa drugs or any ACE inhibitor. Do not take hydrochlorothiazide and benazepril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
Before taking this medicine
You should not use this medicine if you are allergic to hydrochlorothiazide or benazepril, or if:
you are unable to urinate;
you have ever had angioedema;
you recently took a heart medicine called sacubatril;
you are allergic to sulfa drugs; or
Do not take hydrochlorothiazide and benazepril within 36 hours before or after taking medicine that contains sacubatril (such as Entresto).
If you have diabetes, do not use hydrochlorothiazide and benazepril together with any medication that contains aliskiren (such as Tekturna or Tekamlo).
You may also need to avoid taking hydrochlorothiazide and benazepril with aliskiren if you have kidney disease.
To make sure hydrochlorothiazide and benazepril is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
congestive heart failure;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
an allergy to sulfa drugs or penicillin; or
if you are on a low salt diet.
Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Benazepril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medicine.
How should I take hydrochlorothiazide and benazepril?
Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking hydrochlorothiazide and benazepril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.
Your blood pressure will need to be checked often. Your kidney function may also need to be checked. Your blood and urine may also be tested if you have been vomiting or are dehydrated.
If you need surgery, tell the surgeon ahead of time that you are using hydrochlorothiazide and benazepril.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking hydrochlorothiazide and benazepril?
Drinking alcohol can further lower your blood pressure and may increase certain side effects of this medicine.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not use potassium supplements or salt substitutes while you are taking this medicine, unless your doctor has told you to.
Hydrochlorothiazide and benazepril side effects
Get emergency medical help if you have signs of an allergic reaction (hives, severe stomach pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
fever, chills, flu-like symptoms, sore throat, mouth sores;
high potassium--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
kidney problems--little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;
liver problems--stomach pain (upper right side), loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Hydrochlorothiazide and benazepril dosing information
Usual Adult Dose for Hypertension:
Benazepril 5 to 20 mg-Hydrochlorothiazide 6.25 to 25 mg orally once a day
Maximum dose: Benazepril 20 mg-Hydrochlorothiazide 25 mg
Comments: May increase dose after 2 to 3 weeks as needed to achieve blood pressure goal.
What other drugs will affect hydrochlorothiazide and benazepril?
Tell your doctor about all your current medicines and any you start or stop using, especially:
a diuretic or "water pill";
This list is not complete. Other drugs may interact with hydrochlorothiazide and benazepril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 13.02.
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- Drug class: ACE inhibitors with thiazides
Other brands: Lotensin HCT