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Aptiom Side Effects

Generic name: eslicarbazepine

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 17, 2024.

Note: This document contains side effect information about eslicarbazepine. Some dosage forms listed on this page may not apply to the brand name Aptiom.

Applies to eslicarbazepine: oral tablet.

Serious side effects of Aptiom

Along with its needed effects, eslicarbazepine (the active ingredient contained in Aptiom) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking eslicarbazepine:

Less common

Less common

Incidence not known

Other side effects of Aptiom

Some side effects of eslicarbazepine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to eslicarbazepine: oral tablet.


The more commonly reported adverse events have included dizziness, somnolence, nausea, headache, diplopia, vomiting, fatigue, vertigo, ataxia, blurred vision, and tremor.


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Alopecia, dry skin, hyperhidrosis, erythema, skin disorder, pruritus

Frequency not reported: Drug reaction with eosinophilia and systemic symptoms (DRESS), nail disorder[Ref]


Uncommon (0.1% to 1%): Anemia

Rare (less than 0.1%): Thrombocytopenia, leukopenia

Frequency not reported: Decreased hematocrit, decreased hemoglobin

Postmarketing reports: Agranulocytosis, megoblastic anemia, pancytopenia[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 28%), somnolence (up to 18%), headache (up to 15%)

Common (1% to 10%): Vertigo, ataxia, balance disorder, tremor, dysarthria, memory impairment

Uncommon (0.1% to 1%): Coordination abnormal, memory impairment, amnesia, hypersomnia, sedation, aphasia, dysesthesia, dystonia, lethargy, parosmia, cerebellar syndrome, convulsion, peripheral neuropathy, nystagmus, speech disorder, dysarthria, burning sensation, paresthesia, migraine[Ref]


Common (1% to 10%): Hyponatremia, decreased appetite

Uncommon (0.1% to 1%): Electrolyte imbalance, dehydration, hypochloremia[Ref]


Common (1% to 10%): Depression, insomnia

Uncommon (0.1% to 1%): Apathy, depression, nervousness, agitation, irritability, attention deficit/hyperactivity disorder, confusional state, mood swings, crying, psychomotor retardation, psychotic disorder[Ref]


Very common (10% or more): Diplopia (up to 11%)

Common (1% to 10%): Blurred vision, visual impairment

Frequency not reported: Oscillopsia, binocular eye movement disorder, ocular hyperemia, saccadic eye movement, eye pain[Ref]


Common (1% to 10%): Hypertension

Frequency not reported: Palpitations, bradycardia, tachycardia, hypotension, peripheral edema, PR interval prolongation[Ref]


Uncommon (0.1% to 1%): Liver disorder

Frequency not reported: Increased transaminases[Ref]


Very common (10% or more): Nausea (up to 16%), vomiting (up to 10%)

Common (1% to 10%): Diarrhea, constipation, abdominal pain

Uncommon (0.1% to 1%): Gastritis, dyspepsia, dry mouth, abdominal discomfort, abdominal distension, gingivitis, melena, toothache

Frequency not reported: Duodenitis, epigastric discomfort, irritable bowel syndrome, odynophagia, stomatitis, increased appetite, decreased appetite, and ageusia[Ref]


Uncommon (0.1% to 1%): Urinary tract infection[Ref]


Common (1% to 10%): Falls, asthenia

Uncommon (0.1% to 1%): Myalgia, bone metabolism disorder, muscular weakness, pain in extremity, back pain, neck pain[Ref]


Common (1% to 10%): Cough

Uncommon (0.1% to 1%): Epistaxis, chest pain

Frequency not reported: Dysphonia[Ref]


Uncommon (0.1% to 1%): Hypothyroidism[Ref]


Common (1% to 10%): Fatigue, asthenia, gait disturbance, peripheral edema

Uncommon (0.1% to 1%): Malaise, chills[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2013) "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.