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Amlodipine / Olmesartan Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 28, 2024.

Applies to amlodipine / olmesartan: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Drugs with direct action on the renin-angiotensin system can cause injury or death to the developing fetus when used during pregnancy.

Stop therapy as soon as possible if pregnancy occurs.

Serious side effects

Along with its needed effects, amlodipine / olmesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / olmesartan:

More common side effects

  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain

Less common side effects

  • fast, irregular, pounding, or racing heartbeat or pulse
  • unusual tiredness or weakness

Incidence not known

  • dark urine
  • decreased urine output
  • diarrhea
  • fever
  • itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • muscle pain or stiffness
  • stomach pain
  • upper right abdominal or stomach pain
  • yellow eyes or skin

Other side effects

Some side effects of amlodipine / olmesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

  • dizziness
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • sleepiness or unusual drowsiness

Incidence not known

  • hives or welts
  • redness of the skin

For healthcare professionals

Applies to amlodipine / olmesartan: oral tablet.

General adverse events

The most common adverse reaction is edema.[Ref]

Other

Amlodipine:

Olmesartan:

There was a greater incidence of edema in women (14.6%) than men (5.6%).[Ref]

Nervous system

Amlodipine:

Olmesartan:

There was a greater incidence of somnolence in women (1.6%) than men (1.3%).[Ref]

Gastrointestinal

Amlodipine:

Olmesartan:

Cardiovascular

Amlodipine:

Olmesartan:

There was a greater incidence of flushing and palpitation in women than men. The incidence of flushing was 4.5% in females and 1.5% in males. The incidence of palpitation was 3.3% in females and 1.4% in males.[Ref]

Musculoskeletal

Amlodipine:

Olmesartan:

Genitourinary

Amlodipine:

Olmesartan:

Metabolic

Amlodipine:

Olmesartan:

Respiratory

Amlodipine:

Olmesartan:

Renal

Olmesartan:

Dermatologic

Amlodipine:

Olmesartan:

Psychiatric

Amlodipine:

Hepatic

Amlodipine:

Olmesartan:

Immunologic

Amlodipine:

Olmesartan:

Ocular

Amlodipine:

Hematologic

Amlodipine:

Olmesartan:

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics."

2. (2007) "Product Information. Azor (amlodipine-olmesartan)." Daiichi Pharmaceuticals

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Amlodipine/olmesartan side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.