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Amlodipine / Celecoxib Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 21, 2023.

Applies to amlodipine / celecoxib: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction, and stroke, which can be fatal.

This risk may occur early in the treatment and may increase with duration of use.

Amlodipine / celecoxib is contraindicated in the setting of CABG surgery.

NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

These events can occur at any time during use and without warning symptoms.

Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Do not stop using this medicine without asking your doctor, even if the pain stops and you feel well. Wait until your doctor prescribes a different medicine to treat your blood pressure.

Using this medicine during the later part of pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may increase your risk of having a heart attack or stroke. This is more likely in people who already have heart disease or in people who use this medicine for a longer time.

This medicine may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (such as a steroid or a blood thinner).

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, or lower legs, severe stomach pain, black, tarry stools, or vomiting of blood or material that looks like coffee grounds, unusual weight gain, yellow skin or eyes, decreased urination, unusual bleeding or bruising, or skin rash. Also, signs of serious heart problems could occur including chest pain or tightness, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Check with your doctor immediately if you notice any of these warning signs.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

This medicine may cause a serious allergic reaction called anaphylaxis, which can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), and acute generalized exanthematous pustulosis (AGEP) can occur during treatment with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

Before having any kind of surgery or medical tests, tell your doctor that you are using this medicine. It may be necessary for you to stop treatment for a while, or to change to a different NSAID before your procedure.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Other side effects

Some side effects of amlodipine / celecoxib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

  • belching
  • body aches or pain
  • ear congestion
  • loss of voice
  • runny or stuffy nose

Less common side effects

  • bleeding after defecation
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty in moving
  • dryness of the throat
  • excess air or gas in the stomach or bowels
  • feeling of constant movement of self or surroundings
  • frequent urge to defecate
  • full feeling
  • hearing loss
  • hoarseness
  • leg cramps
  • loss or thinning of the hair
  • pain or tenderness around the eyes and cheekbones
  • passing gas
  • sensation of spinning
  • straining while passing stool
  • stuffy nose
  • swelling or inflammation of the mouth
  • trouble sleeping
  • uncomfortable swelling around the anus
  • voice changes

Rare side effects

  • abnormal ejaculation
  • burning, dry, or itching eyes
  • decreased sexual performance or desire
  • discharge, excessive tearing
  • double vision
  • eye pain
  • feeling unusually cold
  • lack or loss of strength
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • seeing double
  • shivering
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unsteady walk

Incidence not known

  • loss of sense of smell or taste
  • swelling of the breasts or breast soreness in both females and males

Serious side effects

Along with its needed effects, amlodipine / celecoxib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / celecoxib:

Less common side effects

  • arm, back, or jaw pain
  • black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • blurred vision
  • chest pain, discomfort, tightness, or heaviness
  • cloudy urine
  • cough
  • cough producing mucus
  • cracked, dry, scaly skin
  • diarrhea
  • difficult, burning, or painful urination
  • difficulty in swallowing
  • dizziness
  • fainting
  • fast or irregular breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • frequent urge to urinate
  • headache, severe and throbbing
  • heartburn
  • increased sensitivity of the skin to sunlight
  • itching, skin rash
  • joint or muscle pain or stiffness
  • loss of appetite
  • loss of consciousness
  • nausea
  • nervousness
  • noisy breathing
  • nosebleed
  • pain in the lower back
  • pain or burning in the throat
  • pain or discomfort in the arms, jaw, back, or neck
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • redness or other discoloration of the skin
  • severe sunburn
  • slow heartbeat
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips or tongue or inside the mouth
  • stomach pain or tenderness
  • sudden decrease in the amount of urine
  • swelling of the eyes, eyelids, face, arms, or legs
  • swelling, tenderness, warmth, blistering, crusting, irritation, itching, or reddening of the skin
  • trouble breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Rare side effects

  • anxiety
  • bloody nose
  • bloating
  • changes in skin color, pain, tenderness, or swelling of the foot or leg
  • chills
  • cold, pale or a bluish skin color of the fingers or toes
  • confusion
  • constipation
  • darkened urine
  • decreased frequency or amount of urine
  • dilated neck veins
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • gaseous stomach pain
  • increased blood pressure
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • irregular breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • numbness and tingling of the face, fingers, or toes
  • pain in the arms, legs, or lower back, especially in the calves or heels upon exertion
  • pale, bluish-colored, or cold hands or feet
  • rapid, shallow breathing
  • recurrent fever
  • severe constipation
  • severe stomach pain, cramping, or burning
  • sores, welts, or blisters
  • stomach fullness
  • swollen glands
  • unexplained weight loss
  • vomiting of blood or material that looks like coffee grounds, severe and continuing
  • weak or absent pulses in the legs
  • weight gain
  • yellow eyes or skin

Incidence not known

  • clay-colored stools
  • cold sweats
  • muscle pain or cramps
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • stiff neck or back
  • unpleasant breath odor
  • upper right abdominal or stomach pain

For healthcare professionals

Applies to amlodipine / celecoxib: oral tablet.

General adverse events

The most commonly reported adverse events included infection, headache, edema, hypertension, and diarrhea.[Ref]

Nervous system

Amlodipine:

Celecoxib:

Other

Amlodipine:

Celecoxib:

Cardiovascular

Amlodipine:

Celecoxib:

Gastrointestinal

Amlodipine:

Celecoxib:

Respiratory

Amlodipine:

Celecoxib:

Musculoskeletal

Amlodipine:

Celecoxib:

Dermatologic

Amlodipine:

Celecoxib:

Psychiatric

Amlodipine:

Celecoxib:

Ocular

Amlodipine:

Celecoxib:

Genitourinary

Amlodipine:

Celecoxib:

Metabolic

Amlodipine:

Celecoxib:

Hematologic

Amlodipine:

Celecoxib:

Hepatic

Amlodipine:

Celecoxib:

Endocrine

Amlodipine:

Celecoxib:

Immunologic

Amlodipine:

Celecoxib:

Renal

Celecoxib:

See also:

References

1. (2018) "Product Information. Consensi (amlodipine-celecoxib)." Kitov Pharmaceuticals

Further information

Amlodipine/celecoxib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.