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Amlodipine / celecoxib Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 18, 2023.

Applies to amlodipine / celecoxib: oral tablet.

Warning

Oral route (Tablet)

NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction, and stroke, which can be fatal. This risk may occur early in the treatment and may increase with duration of use. Amlodipine / celecoxib is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.

Serious side effects

Along with its needed effects, amlodipine / celecoxib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / celecoxib:

Less common

Rare

Incidence not known

Other side effects

Some side effects of amlodipine / celecoxib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Rare

Incidence not known

For Healthcare Professionals

Applies to amlodipine / celecoxib: oral tablet.

General

The most commonly reported adverse events included infection, headache, edema, hypertension, and diarrhea.[Ref]

Nervous system

Amlodipine:

Common (1% to 10%): Dizziness, somnolence

Uncommon (0.1% to 1%): Syncope, hypoesthesia, neuropathy peripheral, paresthesia, tremor, vertigo

Celecoxib:

Very common (10% or more): Headache (up to 15.8%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Cerebral infarction

Frequency not reported: Hypertonia, hypoesthesia, migraine, paresthesia, vertigo, somnolence, cerebrovascular accident, syncope, ataxia

Postmarketing reports: Aseptic meningitis, dysgeusia, anosmia, fatal intracranial hemorrhage[Ref]

Other

Amlodipine:

Very common (10% or more): Edema (up to 14.6%)

Common (1% to 10%): Fatigue, asthenia

Uncommon (0.1% to 1%): Chest pain, malaise, pain, tinnitus

Celecoxib:

Common (1% to 10%): Peripheral edema, accidental injury, pyrexia, injury and poisoning

Frequency not reported: Chest pain, cyst not otherwise specified, edema generalized, face edema, fatigue, influenza-like symptoms, pain, peripheral pain, deafness, tinnitus, alkaline phosphatase increased, sudden death, blood culture positive[Ref]

Cardiovascular

Amlodipine:

Common (1% to 10%): Flushing, palpitation

Uncommon (0.1% to 1%): Arrhythmia, bradycardia, tachycardia, vasculitis, peripheral ischemia, hot flushes

Celecoxib:

Very common (10% or more): Hypertension (up to 12.5%)

Uncommon (0.1% to 1%): Angina unstable, aortic valve incompetence, coronary artery atherosclerosis, sinus bradycardia, ventricular hypertrophy, deep vein thrombosis

Frequency not reported: Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction, hot flushes, palpitation, tachycardia, congestive heart failure, ventricular fibrillation, thrombophlebitis, blood pressure increased

Postmarketing reports: Vasculitis[Ref]

Gastrointestinal

Amlodipine:

Common (1% to 10%): Nausea, abdominal pain

Uncommon (0.1% to 1%): Constipation, dysphagia, diarrhea, flatulence, pancreatitis, vomiting, gingival hyperplasia, dry mouth

Celecoxib:

Very common (10% or more): Diarrhea (up to 10.5%)

Common (1% to 10%): Dyspepsia, abdominal pain, nausea, flatulence, abdominal pain upper, vomiting, gastroesophageal reflux disease

Frequency not reported: Constipation, diverticulitis, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, hemorrhoids, hiatal hernia, melena, dry mouth, stomatitis, tenesmus, intestinal obstruction, intestinal perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus, post-dental extraction alveolar osteitis, upper gastrointestinal ulcers[Ref]

Respiratory

Amlodipine:

Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Epistaxis

Celecoxib:

Common (1% to 10%): Upper respiratory infection, sinusitis, pharyngitis, rhinitis, nasopharyngitis, cough, dyspnea

Frequency not reported: Epistaxis, bronchitis, bronchospasm, bronchospasm aggravated, laryngitis, pneumonia, pulmonary embolism[Ref]

Musculoskeletal

Amlodipine:

Common (1% to 10%): Muscle cramps

Uncommon (0.1% to 1%): Arthralgia, arthrosis, myalgia, back pain, rigors

Celecoxib:

Common (1% to 10%): Back pain, arthralgia

Uncommon (0.1% to 1%): Epicondylitis, tendon rupture

Frequency not reported: Leg cramps, creatine phosphokinase increased, arthrosis, myalgia, synovitis, tendinitis, blood creatine phosphokinase increased[Ref]

Dermatologic

Amlodipine:

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Angioedema, erythema multiforme, rash erythematosus, rash maculopapular, sweating increased, purpura

Celecoxib:

Common (1% to 10%): Rash

Frequency not reported: Ecchymosis, alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematosus, rash maculopapular, skin disorder, skin dry, sweating increased, urticaria, dermatitis contact

Postmarketing reports: Angioedema[Ref]

Psychiatric

Amlodipine:

Uncommon (0.1% to 1%): Insomnia, nervousness, depression, abnormal dreams, anxiety, depersonalization

Celecoxib:

Common (1% to 10%): Insomnia

Frequency not reported: Anxiety, depression, nervousness, suicide[Ref]

Ocular

Amlodipine:

Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, diplopia, eye pain

Celecoxib:

Common (1% to 10%): Eye disorders

Uncommon (0.1% to 1%): Vitreous floaters, conjunctival hemorrhage[Ref]

Genitourinary

Amlodipine:

Common (1% to 10%): Sexual dysfunction

Uncommon (0.1% to 1%): Micturition frequency, micturition disorder, nocturia

Celecoxib:

Uncommon (0.1% to 1%): Ovarian cyst

Frequency not reported: Albuminuria, dysuria, hematuria, micturition frequency, bacteriuria present, hematuria present, proteinuria present, urine analysis abnormal[Ref]

Metabolic

Amlodipine:

Uncommon (0.1% to 1%): Anorexia, weight gain, weight decrease, hyperglycemia, thirst

Celecoxib:

Uncommon (0.1% to 1%): Blood potassium increased, blood sodium increased

Frequency not reported: Hypercholesterolemia, hyperglycemia, hypokalemia, weight increased, anorexia, appetite increased, blood glucose increased, blood uric acid increased

Postmarketing reports: Hypoglycemia, hyponatremia[Ref]

Hematologic

Amlodipine:

Uncommon (0.1% to 1%): Leukopenia, thrombocytopenia

Celecoxib:

Uncommon (0.1% to 1%): Hemoglobin decreased by more than 2 g/dL, anemia

Frequency not reported: Thrombocythemia, thrombocytopenia, activated partial thromboplastin time prolonged, hematocrit decreased, hemoglobin decreased

Postmarketing reports: Agranulocytosis, aplastic anemia, pancytopenia, leucopenia[Ref]

Hepatic

Amlodipine:

Postmarketing reports: Jaundice, hepatic enzyme elevations

Celecoxib:

Common (1% to 10%): ALT or AST elevation of 1.2 to less than 3 times the upper limit of normal

Uncommon (0.1% to 1%): ALT or AST elevation of 3 or more times the upper limit of normal

Frequency not reported: Cholelithiasis, liver function tests abnormal, transaminase increased

Postmarketing reports: Liver necrosis, hepatitis, jaundice, hepatic failure[Ref]

Endocrine

Amlodipine:

Postmarketing reports: Gynecomastia

Celecoxib:

Uncommon (0.1% to 1%): Blood testosterone decreased[Ref]

Immunologic

Amlodipine:

Uncommon (0.1% to 1%): Allergic reaction

Celecoxib:

Very common (10% or more): Infection (up to 25%)

Uncommon (0.1% to 1%): Labyrinthitis

Frequency not reported: Hypersensitivity, allergic reaction, cellulitis, cystitis, peripheral gangrene, sepsis

Postmarketing reports: Anaphylactoid reaction[Ref]

Renal

Celecoxib:

Common (1% to 10%): Nephrolithiasis

Frequency not reported: BUN increased, non-protein nitrogen increased, creatinine increased, renal calculus, acute renal failure

Postmarketing reports: Interstitial nephritis[Ref]

References

1. Product Information. Consensi (amlodipine-celecoxib). Kitov Pharmaceuticals. 2018.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.