Aldactazide Side Effects
Generic name: hydrochlorothiazide / spironolactone
Medically reviewed by Drugs.com. Last updated on Apr 23, 2025.
Note: This document provides detailed information about Aldactazide Side Effects associated with hydrochlorothiazide / spironolactone. Some dosage forms listed on this page may not apply specifically to the brand name Aldactazide.
Applies to hydrochlorothiazide / spironolactone: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
This drug has been reported to be tumorigenic in rat chronic toxicity studies.
Use this drug only as indicated.
Fixed-dose spironolactone/hydrochlorothiazide is not indicated for the initial treatment of edema or hypertension.
Precautions
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.
Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium, certain diuretics (eg, amiloride, triamterene (Dyazide®, Dyrenium®, Maxzide®, Midamor®, Moduretic®), or other products containing spironolactone (Aldactone®).
Check with your doctor immediately if blurred vision, difficulty reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor may want an eye doctor to check your eyes.
This medicine may cause dizziness, drowsiness, lightheadedness, or fainting, especially when you get up suddenly from a lying or sitting position. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.
Check with your doctor right away if you become sick while taking this medicine, especially if you have severe or continuing nausea, vomiting, or diarrhea that does not stop. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather.
This medicine may affect blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.
This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.
This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.
Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.
Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Aldactazide
Along with its needed effects, hydrochlorothiazide / spironolactone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / spironolactone:
Incidence not known
- back or leg pains
- blistering, peeling, or loosening of the skin
- bloody or black, tarry stools
- bloody or cloudy urine
- blue lips and fingernails
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain or tightness
- clay-colored stools
- clear or bloody discharge from the nipple
- confusion
- cough or hoarseness
- dark urine
- decreased appetite
- diarrhea
- difficult, fast, or noisy breathing
- difficulty with swallowing
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast or irregular heartbeat
- fever with or without chills
- flushed, dry skin
- fruit-like breath odor
- general body swelling
- general feeling of discomfort or illness
- greatly decreased frequency of urination or amount of urine
- hives or welts, skin rash
- increased hunger
- increased thirst
- inverted nipple
- joint pain, stiffness, or swelling
- lower back or side pain
- lump in the breast or under the arm
- muscle cramps or pain
- nausea and vomiting
- numbness, tingling, pain, or weakness in the hands, feet, or lips
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- persistent non-healing sore
- pink growth
- pinpoint red or purple spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red, irritated eyes
- reddish patch or irritated area
- redness or swelling of the breast
- redness, soreness, or itching skin
- seizures
- shiny bump
- sore on the skin of the breast that does not heal
- sores, ulcers, or white spots on the lips or in the mouth
- stomach cramping, burning, or tenderness
- swelling of the face, hands, fingers, feet, or lower legs
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- trembling
- trouble breathing
- unusual bleeding or bruising
- unusual tiredness or weakness
- white, yellow or waxy scar-like area
- yellow eyes or skin
Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / spironolactone:
Symptoms of overdose
- difficulty with sleeping
- disorientation
- drowsiness to profound coma
- hallucination
- lethargy
- lightheadedness
- mood or other mental changes
- rash with flat lesions or small raised lesions on the skin
Other side effects of Aldactazide
Some side effects of hydrochlorothiazide / spironolactone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- absent, missed, or irregular menstrual periods
- bleeding after menopause
- burning feeling in the chest or stomach
- discoloration of the skin
- feeling of constant movement of self or surroundings
- inability to have or keep an erection
- increased sensitivity of the skin to sunlight
- muscle spasm
- restlessness
- sensation of spinning
- severe sunburn
- stomach upset
- stopping of menstrual bleeding
- swelling of the breasts or breast soreness in both females and males
For healthcare professionals
Applies to hydrochlorothiazide / spironolactone: oral tablet.
Endocrine adverse events
Spironolactone:
- Frequency not reported: Gynecomastia[Ref]
Other
Hydrochlorothiazide:
- Frequency not reported: Weakness, fever, vertigo
Spironolactone:
- Frequency not reported: Breast pain, fever[Ref]
Cardiovascular
Hydrochlorothiazide:
- Frequency not reported: Hypotension, orthostatic hypotension, necrotizing angitis, vasculitis
Spironolactone:
- Frequency not reported: Vasculitis[Ref]
Hepatic
Hydrochlorothiazide:
- Frequency not reported: Pancreatitis, intrahepatic cholestatic jaundice
Spironolactone:
- Frequency not reported: Mixed cholestatic/hepatocellular toxicity[Ref]
Gastrointestinal
Hydrochlorothiazide:
- Frequency not reported: Diarrhea, vomiting, sialoadenitis, cramping, constipation, gastric irritation, nausea
Spironolactone:
- Frequency not reported: Gastric bleeding, ulceration, gastritis, diarrhea, cramping, nausea, vomiting[Ref]
Metabolic
Hydrochlorothiazide:
- Frequency not reported: Anorexia, electrolyte imbalance, hyperglycemia, hyperuricemia
Spironolactone:
- Frequency not reported: Hyperkalemia, electrolyte disturbances[Ref]
Ocular
Hydrochlorothiazide:
- Frequency not reported: Acute myopia, acute angle closure glaucoma, transient blurred vision, xanthopsia[Ref]
Hematologic
Hydrochlorothiazide:
- Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia
Spironolactone:
- Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia[Ref]
Immunologic
Hydrochlorothiazide:
- Frequency not reported: Anaphylactic reactions
Spironolactone:
- Frequency not reported: Anaphylactic reactions[Ref]
Dermatologic
Hydrochlorothiazide:
- Frequency not reported: Cutaneous vasculitis, photosensitivity, urticaria, rash, purpura, erythema multiforme, pruritus
Spironolactone:
- Frequency not reported: Urticaria, maculopapular or erythematous cutaneous eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, alopecia, pruritus
Postmarketing: Non-melanoma skin cancer[Ref]
Respiratory
Hydrochlorothiazide:
- Frequency not reported: Pneumonitis, pulmonary edema[Ref]
Genitourinary
Hydrochlorothiazide:
- Frequency not reported: Glycosuria
Spironolactone:
- Frequency not reported: Inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding[Ref]
Musculoskeletal
Hydrochlorothiazide:
- Frequency not reported: Muscle spasm
Spironolactone:
- Frequency not reported: Leg cramps[Ref]
Nervous system
Hydrochlorothiazide:
- Frequency not reported: Paresthesias, dizziness, headache
Spironolactone:
- Frequency not reported: Lethargy, ataxia, dizziness, headache, drowsiness[Ref]
Psychiatric
Hydrochlorothiazide:
- Frequency not reported: Restlessness
Spironolactone:
- Frequency not reported: Mental confusion[Ref]
Renal
Hydrochlorothiazide:
- Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis
Spironolactone:
- Frequency not reported: Renal dysfunction, renal failure[Ref]
Oncologic
Spironolactone:
- Frequency not reported: Carcinoma of the breast[Ref]
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References
1. (2015) "Product Information. Aldactazide (hydrochlorothiazide-spironolactone)." Pfizer U.S. Pharmaceuticals Group
More about Aldactazide (hydrochlorothiazide / spironolactone)
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- During pregnancy
- Generic availability
- Drug class: potassium sparing diuretics with thiazides
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Further information
Aldactazide side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.