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Pseudoephedrine and triprolidine

Generic name: pseudoephedrine and triprolidine (soo doe e FED rin and try PROE li deen )
Brand name: Aphedrid, A-Phedrin, Aprodine, Histafed, Vi-Sudo, Wal-Act, ...show all 41 brand names
Dosage forms: oral liquid (10 mg-0.938 mg/mL); oral syrup (30 mg-1.25 mg/5 mL); oral tablet (60 mg-2.5 mg)
Drug class: Upper respiratory combinations

Medically reviewed by Drugs.com on Jun 14, 2021. Written by Cerner Multum.

What is pseudoephedrine and triprolidine?

Pseudoephedrine and triprolidine is a combination antihistamine and decongestant medicine that is used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies or the common cold.

Pseudoephedrine and triprolidine may also be used for purposes not listed in this medication guide.

Warnings

Do not use the medicine to make a child sleepy. Misuse of pseudoephedrine and triprolidine may cause death in very young children.

Before taking this medicine

You should not use this medicine if you are allergic to pseudoephedrine or triprolidine.

Do not use pseudoephedrine and triprolidine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

How should I take pseudoephedrine and triprolidine?

Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms clear up.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Always follow directions on the medicine label about giving cough or cold medicine to a child. Do not use the medicine only to make a child sleepy. Death can occur from the misuse of cough or cold medicines in very young children.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken pseudoephedrine and triprolidine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since pseudoephedrine and triprolidine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking pseudoephedrine and triprolidine?

Avoid driving or hazardous activity until you know how pseudoephedrine and triprolidine will affect you. Your reactions could be impaired.

Ask a doctor or pharmacist before using other cough or cold medicines that may contain similar ingredients.

Drinking alcohol can increase certain side effects of triprolidine.

Pseudoephedrine and triprolidine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe dizziness;

  • nervousness;

  • trouble sleeping; or

  • high blood pressure (severe headache, pounding in your neck or ears).

Common side effects may include:

  • dizziness, drowsiness;

  • dry mouth, nose, or throat;

  • constipation;

  • blurred vision; or

  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pseudoephedrine and triprolidine dosing information

Usual Adult Dose for Allergic Rhinitis:

Pseudoephedrine 60 mg/ triprolidine 2.5 mg per tablet: 1 tablet orally every 4 to 6 hours
Maximum dose: 4 tablets per 24 hours

Pseudoephedrine 30 mg/ triprolidine 1.25 mg per 5 mL: 10 mL orally every 6 hours

Usual Adult Dose for Cold Symptoms:

Pseudoephedrine 60 mg/ triprolidine 2.5 mg per tablet: 1 tablet orally every 4 to 6 hours
Maximum dose: 4 tablets per 24 hours

Pseudoephedrine 30 mg/ triprolidine 1.25 mg per 5 mL: 10 mL orally every 6 hours

Usual Pediatric Dose for Allergic Rhinitis:

Pseudoephedrine 60 mg/ triprolidine 2.5 mg per tablet:
12 years and older: 1 tablet orally every 4 to 6 hours
Maximum dose: 4 tablets per 24 hours

Pseudoephedrine 30 mg/ triprolidine 1.25 mg per 5 mL:
12 years and older: 10 mL orally every 6 hours

Usual Pediatric Dose for Cold Symptoms:

Pseudoephedrine 60 mg/ triprolidine 2.5 mg per tablet:
12 years and older: 1 tablet orally every 4 to 6 hours
Maximum dose: 4 tablets per 24 hours

Pseudoephedrine 30 mg/ triprolidine 1.25 mg per 5 mL:
12 years and older: 10 mL orally every 6 hours

What other drugs will affect pseudoephedrine and triprolidine?

Ask a doctor or pharmacist before using other medicines that can cause drowsiness (such as opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Not all possible interactions are listed here.

Does Pseudoephedrine/triprolidine interact with my other drugs?

Enter other medications to view a detailed report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.