Generic Name:morphine sulfate controlled-release tablets: MS Contin
Medically reviewed on October 4, 2017.
What is MS Contin?
MS Contin extended-release tablets are a strong prescription pain medicine used to treat moderate to severe pain that requires around-the-clock, long-term treatment. MS Contin is used when other pain treatments such as non-opioid pain medicines or immediate-release opioid medicines do not treat the pain well enough or cannot be tolerated.
MS Contin extended-release tablets are for around-the-clock treatment of pain. This form of morphine is not for use on an as-needed basis for pain.
You should not take MS Contin if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or a bowel obstruction called paralytic ileus.
Morphine can slow or stop your breathing, and may be habit-forming. MISUSE OF THIS MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.
Taking this medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
Fatal side effects can occur if you use this medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.
Before taking this medicine
You should not take MS Contin if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have:
severe asthma or breathing problems; or
a blockage in your stomach or intestines.
Do not use MS Contin if you have used a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
To make sure MS Contin is safe for you, tell your doctor if you have ever had:
any type of breathing problem or lung disease;
a head injury, brain tumor, or seizures;
a drug or alcohol addiction, or mental illness;
liver or kidney disease;
problems with your gallbladder, pancreas, or thyroid; or
if you use a sedative like Valium (diazepam, alprazolam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Versed, Xanax, and others).
Some medicines can interact with morphine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.
If you use MS Contin while you are pregnant your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant.
Do not breast-feed while taking morphine. This medicine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.
How should I use MS Contin?
Take MS Contin exactly as prescribed by your doctor. Follow all directions on your prescription label. Morphine can slow or stop your breathing, especially when you start using this medicine or whenever your dose is changed. Never use MS Contin in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.
Morphine may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away MS Contin is against the law.
Stop taking all other around-the-clock narcotic pain medications when you start taking MS Contin.
Do not crush, chew, or break an extended-release tablet. Swallow it whole to avoid exposure to a potentially fatal dose.
Do not stop using MS Contin suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using morphine.
Never crush or break a MS Contin extended-release tablet to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of morphine and similar prescription drugs.
Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. Morphine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Do not keep leftover MS Contin tablets. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush any unused tablets down the toilet.
See also: Dosage Information (in more detail)
What happens if I miss a dose?
MS Contin is taken 2 or 3 times per day. Since morphine is used for pain, you are not likely to miss a dose. If you do miss a dose, take the medicine as soon as you remember. Then take your next dose as follows:
If you take MS Contin 3 times per day: Take your next dose 8 hours after taking the missed dose.
If you take MS Contin 2 times per day: Take your next dose 12 hours after taking the missed dose.
Do not take extra medicine to make up a missed dose. Do not take more than your prescribed dose in a 24-hour period.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A morphine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.
What should I avoid while using MS Contin?
Do not drink alcohol. Dangerous side effects or death could occur.
This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how MS Contin will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
MS Contin side effects
Get emergency medical help if you have signs of an allergic reaction to MS Contin: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Like other opioid medicines, MS Contin can slow your breathing. Death may occur if breathing becomes too weak. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Call your doctor at once if you have:
slow heart rate, sighing, weak or shallow breathing;
chest pain, fast or pounding heartbeats;
extreme drowsiness, feeling like you might pass out; or
low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.
MS Contin is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.
Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.
Common MS Contin side effects may include:
constipation, stomach pain, nausea, vomiting;
headache, tired feeling;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect MS Contin?
Narcotic (opioid) medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:
other narcotic medications - opioid pain medicine or prescription cough medicine;
drugs that make you sleepy or slow your breathing - a sleeping pill, muscle relaxer, sedative, tranquilizer, or antipsychotic medicine; or
drugs that affect serotonin levels in your body - medicine for depression, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting.
This list is not complete. Other drugs may interact with morphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use MS Contin only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 12.01.
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- Drug class: narcotic analgesics