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Kadian

Generic Name: morphine (MOR feen)
Brand Names: Kadian

Medically reviewed on Nov 7, 2018

What is Kadian?

Kadian (morphine) is an opioid medication. An opioid is sometimes called a narcotic.

Kadian extended-release capsules are used to treat moderate to severe pain.

Kadian extended-release capsules are used for around-the-clock treatment of pain when other pain treatments, such as non-opioid pain medicines or immediate-release opioid medicines, do not treat your pain well enough or you cannot tolerate them.

Kadian is not for use on an as-needed basis for pain.

Important Information

You should not take Kadian if you have severe asthma or breathing problems, a blockage in your stomach or intestines, or a bowel obstruction called paralytic ileus.

Morphine can slow or stop your breathing, and may be habit-forming MISUSE OF KADIAN CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, , especially in a child or other person using the medicine without a prescription. Keep the medication in a place where others cannot get to it.

Taking Kadian during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use Kadian with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Before taking this medicine

You should not take Kadian if you have ever had an allergic reaction to morphine or other narcotic medicines, or if you have:

  • severe asthma or breathing problems; or

  • a blockage in your stomach or intestines.

Do not use Kadian if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

To make sure Kadian is safe for you, tell your doctor if you have ever had:

  • a head injury, brain tumor, or seizures;

  • a drug or alcohol addiction, or mental illness;

  • urination problems;

  • liver or kidney disease; or

  • problems with your gallbladder, pancreas, or thyroid.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Do not breast-feed while taking morphine. Morphine can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby.

How should I use Kadian?

Take Kadian exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use morphine in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of this medicine.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Stop taking all other around-the-clock narcotic pain medications when you start taking Kadian.

Swallow the capsule whole to avoid exposure to a potentially fatal overdose. Crushing, chewing, or dissolving the pellets will result in uncontrolled delivery of morphine and can lead to overdose or death.

To make swallowing easier, you may open the extended-release capsule and sprinkle the medicine into a spoonful of applesauce. Swallow right away without chewing. Rinse the mouth to ensure all pellets have been swallowed. Do not save the mixture for later use.

Do not stop using Kadian suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Never crush or break a Kadian capsule to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death with the misuse of morphine and similar prescription drugs.

Store at room temperature, away from heat, moisture, and light. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

Kadian Dosing Information

Usual Adult Dose for Pain:

Extended-release capsules:
Different extended-release products are not bioequivalent. Conversion from one extended-release product to the same total daily dose of another extended-release product may lead to either excessive sedation at peak or inadequate analgesia at trough. Individual product information should be consulted before prescribing and the dosage should be adjusted to the individual patient.

Opioid naive:
Initial dose: 30 mg orally every 24 hours

Opioid tolerant:
Appropriate dose should be taken 1 to 2 times daily.

What happens if I miss a dose?

Kadian is usualy taken once per day (every 24 hours) or twice daily (every 12 hours). Since Kadian is used for pain, you are not likely to miss a dose. If you do miss a dose, take the medicine as soon as you remember. Then take your next dose as follows:

  • If you take Kadian 2 times per day: Take your next dose 12 hours after taking the missed dose.

  • If you take Kadian 1 time per day: Take your next dose 24 hours after taking the missed dose.

Do not take two doses at one time. Do not take more than your prescribed dose in a 24-hour period.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A morphine overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, very slow breathing, or coma.

What should I avoid while using Kadian?

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or hazardous activity until you know how morphine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Kadian side effects

Get emergency medical help if you have signs of an allergic reaction to Kadian: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

To make sure Kadian is safe for you, tell your doctor if you have ever had:

  • slow heart rate, sighing, weak or shallow breathing;

  • chest pain, fast or pounding heartbeats;

  • extreme drowsiness, feeling like you might pass out; or

  • low cortisol levels - nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common Kadian side effects may include:

  • drowsiness, dizziness, tiredness;

  • constipation, stomach pain, nausea, vomiting;

  • sweating; or

  • feelings of extreme happiness or sadness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Kadian?

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

This list is not complete. Other drugs may interact with morphine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Kadian only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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