What are the new drugs for rheumatoid arthritis (RA)?
The newest drugs for the treatment of rheumatoid arthritis are the Janus kinase (JAK) inhibitors, which are FDA approved under the brand names Rinvoq, Olumiant, and Xeljanz.
Janus kinase (JAK) inhibitors work by blocking the activity of one or more of the Janus kinase enzymes (JAK1, JAK2, JAK3, TYK2) in the JAK-STAT signaling pathway, an intracellular pathway that plays a major role in the release of the pro-inflammatory cytokines that stimulate inflammation in rheumatoid arthritis.
Janus kinase (JAK) inhibitors are part of a wider group of drugs called DMARDs (Disease-Modifying Anti-Rheumatic Drugs). DMARDs work to slow the progression of joint damage in rheumatoid arthritis.
For more information on the treatment of rheumatoid arthritis, see Rheumatoid Arthritis: Symptoms, Diagnosis & Treatment Options
New Treatments for Rheumatoid Arthritis - Latest FDA Approvals
Drug | Drug Class | Administration | Company | FDA Approved for RA | RA Indication | Other Indications |
---|---|---|---|---|---|---|
upadacitinib (Rinvoq) | Janus kinase (JAK) inhibitor |
oral extended-release tablets once daily |
AbbVie Inc. | 16-Aug-2019 |
|
|
baricitinib (Olumiant) | Janus kinase (JAK) inhibitor | oral tablets once daily | Eli Lilly and Company | 31-May-2018 |
|
|
sarilumab (Kevzara) | interleukin-6 (IL-6) receptor antagonist |
subcutaneous injection every 2 weeks |
Sanofi and Regeneron | 22-May-2017 |
|
|
tofacitinib (Xeljanz XR) | Janus kinase (JAK) inhibitor | oral extended-release tablets once daily | Pfizer Inc. | 23-Feb-2016 |
|
|
golimumab (Simponi Aria) | tumor necrosis factor (TNF) blocker | intravenous infusion at weeks 0 and 4, then every 8 weeks | Janssen Biotech, Inc. | 18-Jul-2013 |
|
|
tofacitinib (Xeljanz) | Janus kinase (JAK) inhibitor | oral tablets twice daily | Pfizer Inc. | 6-Nov-2012 |
|
|
tocilizumab (Actemra) | interleukin-6 (IL-6) receptor antagonist |
intravenous infusion every 4 weeks subcutaneous injection every 2 weeks, then every week |
Genentech, Inc. | 8-Jan-2010 |
|
|
certolizumab pegol (Cimzia) | tumor necrosis factor (TNF) blocker | subcutaneous injection at weeks 0, 2, and 4, then every 2-4 weeks | UCB, Inc. | 13-May-2009 |
|
|
golimumab (Simponi) | tumor necrosis factor (TNF) blocker |
subcutaneous injection once a month |
Janssen Biotech, Inc. | 24-Apr-2009 |
|
|
rituximab (Rituxan) | CD20-directed cytolytic antibody | intravenous infusion two infusions separated by 2 weeks (one course) every 24 weeks or based on clinical evaluation (not sooner than every 16 weeks) | Genentech, Inc. | 28-Feb-2006 |
|
|
abatacept (Orencia) | selective T cell costimulation modulator |
intravenous infusion at 0, 2 and 4 weeks, then every 4 weeks subcutaneous injection once weekly |
Bristol-Myers Squibb Company | 23-Dec-2005 |
|
|
adalimumab (Humira) | tumor necrosis factor (TNF) blocker |
subcutaneous injection every 2 weeks |
AbbVie Inc. | 31-Dec-2002 |
|
|
anakinra (Kineret) | interleukin-1 receptor antagonist |
subcutaneous injection once daily |
Swedish Orphan Biovitrum AB | 14-Nov-2001 |
|
|
infliximab (Remicade) | tumor necrosis factor (TNF) blocker | intravenous infusion at 0, 2, and 6 weeks, then every 8 weeks | Janssen Biotech, Inc. | 10-Nov-1999 |
|
|
etanercept (Enbrel) | tumor necrosis factor (TNF) blocker |
subcutaneous injection once weekly |
Immunex Corporation | 2-Nov-1998 |
|
|
leflunomide (Arava) | pyrimidine synthesis inhibitor | oral tablets once daily | sanofi-aventis U.S. LLC | 10-Sep-1998 |
|
|
The biosimilars for Actemra, Rituxan, Humira, Remicade, and Enbrel are also FDA approved for the treatment of rheumatoid arthritis:
Related questions
- How soon can you start chemo after port placement?
- What is the difference between Truxima and Rituxan?
- What is the success rate of Rituxan (rituximab) in patients with blood cancers?
Actemra (tocilizumab) Biosimilars
Rituxan (rituximab) Biosimilars
Humira (adalimumab) Biosimilars
- Amjevita (adalimumab-atto)
- Cyltezo (adalimumab-adbm)
- Hyrimoz (adalimumab-adaz)
- Hadlima (adalimumab-bwwd)
- Abrilada (adalimumab-afzb)
- Hulio (adalimumab-fkjp)
- Yusimry (adalimumab-aqvh)
- Idacio (adalimumab-aacf)
- Yuflyma (adalimumab-aaty)
- Simlandi (adalimumab-ryvk)
Remicade (infliximab) Biosimilars
- Inflectra (infliximab-dyyb)
- Renflexis (infliximab-abda)
- Ixifi (infliximab-qbtx)
- Avsola (infliximab-axxq)
Enbrel (etanercept) Biosimilars
Read next
What is the success rate of Rituxan (rituximab) in rheumatoid arthritis?
Treatment with Rituxan (rituximab) successfully improves patient outcomes in patients with rheumatoid arthritis including reducing symptoms, reducing levels of fatigue and disability, and increasing health-related quality of life. It also slows the progression of structural damage in joints. Continue reading
What causes infusion reactions to rituximab?
Rituximab infusion reactions are caused primarily by cytokine release in the body. Cytokines are immune system proteins in the body that help to fight infections but can cause an inflammatory response. Infusion reactions may cause hives, itching, shortness of breath, chest pain or dizziness and are a very common side effect of treatment with rituximab (Rituxan). Continue reading
What is the difference between Rituxan and Rituxan Hycela?
Rituxan (rituximab) is administered intravenously (IV), while Rituxan Hycela is given subcutaneously (SC). Continue reading
See also:
Vraylar
Vraylar is a once a day antipsychotic medication used to treat mental health or mood disorders ...
Abilify
Abilify is an antipsychotic medicine used to treat the symptoms of schizophrenia and bipolar ...
Humira
Humira is a tumor necrosis factor blocker used to treat many inflammatory conditions in adults ...
Seroquel
Seroquel is used to treat the symptoms of schizophrenia, bipolar disorder and major depressive ...
Lamictal
Lamictal is an anti-epileptic medication used treat seizures in adults and children over 2 years ...
Depakote
Depakote is used to treat various types of seizure disorders. Learn about side effects ...
Lithium
Lithium is used to treat the manic episodes of manic depression - hyperactivity, rushed speech ...
Carbamazepine
Carbamazepine is used to treat epileptic seizures and nerve pain such as trigeminal neuralgia ...
Risperidone
Risperidone is used to treat schizophrenia and symptoms of bipolar disorder. Learn about side ...
Olanzapine
Olanzapine (brand name Zyprexa) is an atypical antipsychotic that may be used to treat adults and ...
Related medical questions
- What are biologic drugs and how do they work?
- What biosimilars have been approved in the United States?
- Are lung nodules common after Bendeka & Rituxan therapy?
- How much does Humira cost without insurance?
- What happens when you stop taking Humira?
- Does Humira cause weight gain or weight loss?
- How long does it take for Humira to work?
- How long can Humira be out of the fridge?
- What food should I avoid while taking Humira?
- What are monoclonal antibodies?
- How long can you stay on Humira?
- What are biosimilar drugs and how do they compare to biologics?
- Can you drink alcohol while taking Humira?
- Can you take Humira with antibiotics?
- Can I take Humira after covid vaccine?
- Is Humira an immunosuppressant?
- How do you inject Humira?
- Cosentyx vs Humira: How do they compare?
- Does Humira make you feel tired?
- Does Humira cause hair loss?
- What's the difference between Cimzia and Humira?
- Does Humira cause muscle spasms?
- Is Humira good for treating hidradenitis suppurativa?
- Skyrizi vs Humira for plaque psoriasis - How do they compare?
- Is Amjevita interchangeable with Humira?
- What is the difference between Cyltezo and Humira?
- Who are the actors in the Humira commercial?
- What are the new drugs for plaque psoriasis?
- What causes Plaque Psoriasis?
- What is the difference between Amjevita and Humira?
Related support groups
- Rituximab (12 questions, 56 members)
- Humira (69 questions, 370 members)
- Enbrel (25 questions, 212 members)
- Remicade (23 questions, 186 members)
- Rituxan (21 questions, 105 members)
- Xeljanz (21 questions, 38 members)
- Adalimumab (14 questions, 14 members)
- Etanercept (13 questions, 13 members)
- Actemra (13 questions, 52 members)
- Cimzia (10 questions, 44 members)
- Rinvoq (8 questions, 11 members)