Generic Name: baricitinib (BAR i SYE ti nib)
Brand Names: Olumiant
Medically reviewed on August 14, 2018
What is Olumiant?
Olumiant (baricitinib) blocks the activity of certain enzymes involved in activating inflammation in the body.
Olumiant is used to reduce pain, stiffness, and swelling in adults with rheumatoid arthritis after other treatments have failed.
Olumiant also helps slow the progression of bone and joint damage.
Olumiant affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, aches, tiredness, cough, skin sores, diarrhea, weight loss, or burning when you urinate.
You should not start taking Olumiant if you have any kind of infection. Your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Before taking this medicine
You should not use Olumiant if you are allergic to baricitinib, or if you have any kind of infection.
To make sure Olumiant is safe for you, tell your doctor if you have ever had:
a chronic infection;
liver or kidney disease;
hepatitis B or C;
a stomach or intestinal problem such as diverticulitis or an ulcer;
a perforation (a hole or tear) in your esophagus, stomach, or intestines;
a blood clot;
low white or red blood cell counts; or
if you are scheduled to receive any vaccine.
Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common (Ohio River Valley, Mississippi River Valley, and the Southwest).
Using Olumiant may increase your risk of developing certain cancers, such as lymphoma or skin cancer. Ask your doctor about this risk.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
You should not breast-feed while using baricitinib.
How should I take Olumiant?
Take Olumiant exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Before you start treatment with this medicine, your doctor may perform tests to make sure you do not have tuberculosis or other infections.
You may take Olumiant with or without food.
Baricitinib affects your immune system. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.
Store at room temperature away from moisture and heat.
Olumiant dosing information
Usual Adult Dose for Rheumatoid Arthritis:
2 mg orally once a day
-This drug may be taken with or without food.
-This drug may be used as monotherapy or in combination with methotrexate or other DMARDs.
Use: For the treatment of adult patients with moderately to severely active
rheumatoid arthritis who have had an inadequate response to one or more tumor necrosis factor (TNF) antagonist therapies
What happens if I miss a dose?
Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Olumiant?
Do not receive a "live" vaccine while using Olumiant. The vaccine may not work as well and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
Olumiant side effects
Get emergency medical help if you have signs of an allergic reaction to Olumiant: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:
fever, chills, sweating;
tiredness, muscle pain;
increased urination, pain or burning when you urinate;
stomach pain, diarrhea, weight loss; or
cough, shortness of breath, coughing up pink or red mucus.
Further doses may be delayed until your infection clears up.
Also call your doctor at once if you have:
signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;
signs of a blood clot in your leg - swelling, warmth, or redness in an arm or leg;
signs of perforation (a hole or tear) in your stomach or intestines - fever, ongoing stomach pain, change in bowel habits; or
signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.
Common Olumiant side effects may include:
sores on your lips (cold sores);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Olumiant?
Tell your doctor about all your other medicines, especially:
other drugs to treat rheumatoid arthritis - abatacept, adalimumab, anakinra, azathioprine, certolizumab, cyclosporine, etanercept, golimumab, infliximab, rituximab, sarilumab, tocilizumab, tofacitinib.
This list is not complete. Other drugs may interact with baricitinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Olumiant only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 1.01.
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- Drug class: antirheumatics