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Can you drink alcohol while taking Humira?

Medically reviewed by Leigh Ann Anderson, PharmD. Last updated on April 20, 2020.

Official Answer


There are no specific studies to show if it is safe to drink alcohol while using Humira (adalimumab). However, some people may be able to drink alcohol safely in moderation while using Humira. Ask your doctor if you can safely combine alcohol with Humira.

The manufacturer does not list any specific interactions between alcohol and Humira in the package insert, but a reaction still may be possible depending upon your medical conditions, risk factors and other medications that you take.

Moderate alcohol consumption is defined as having up to 1 drink per day for women and up to 2 drinks per day for men, based on Dietary Guidelines.

Humira is noted as a possible cause of serious liver damage, including acute liver failure, in the product label.

  • Alcohol in large quantities can also lead to long-term liver damage. Combining these two agents may worsen your liver function.
  • In addition, elevations in liver enzymes, which may signal the start of liver damage, have been reported with Humira, although patients were also taking other drugs that might have affected their liver function.

Some conditions treated by Humira, such as Crohn’s disease and ulcerative colitis, may be worsened by consumption of alcohol. Certain foods and beverages can aggravate these bowel diseases, especially during a flare-up. It is best to avoid alcohol if it worsens your symptoms.

Humira is commonly used to treat rheumatoid arthritis. Many patients who use Humira also use methotrexate to help control their symptoms. Methotrexate is broken down (metabolized) in the liver. In general, long-term use of methotrexate can also lead to liver toxicity. Most health care providers recommend that patients avoid or limit alcohol consumption when using methotrexate.

What are the signs of liver damage?

Signs and symptoms of of liver damage may include:

  • fever
  • chills
  • joint pain or swelling
  • unusual bleeding or bruising
  • skin rash
  • itching
  • loss of appetite
  • fatigue
  • nausea
  • vomiting
  • stomach pain
  • dark urine
  • pale stools
  • yellowing of the skin or eyes

Call your doctor immediately if you notice any of these symptoms.

Always be sure to inform your doctor and pharmacist of all the medications you take, including over-the-counter (OTC) drugs, vitamins, dietary supplements and herbal products.

Bottom Line

  • For some people, drinking alcohol in moderation may be safe while using Humira, although studies from the manufacturer are not available.
  • In patients at risk of liver disease, or with current liver disease, the use of alcohol may not be safe. Humira itself is noted as a possible cause of serious liver damage in the product label.
  • Some intestinal conditions treated by Humira, such as Crohn’s disease and ulcerative colitis, may be worsened by consumption of alcohol, leading to flare-ups.
  • It is always best to talk to your doctor about alcohol use with any medication, including Humira.

See also: Humira: One Drug, Nine Uses, Billions of Dollars

This is not all the information you need to know about Humira (adalimumab) for safe and effective use. Review the full Humira information here, and discuss this information with your doctor or other health care provider.


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