Generic Name: rituximab (ri TUX i mab)
Brand Name: Riabni, Rituxan, Ruxience, Truxima
What is Riabni?
Riabni is used alone or in combination with other medicines to treat the following conditions in adults:
pemphigus vulgaris--a severe autoimmune reaction that causes blisters and breakdown of the skin and mucous membranes.
Riabni is also used in adults and children at least 2 years old with certain disorders that cause inflammation of blood vessels and other tissues in the body.
Riabni may also be used for purposes not listed in this medication guide.
Riabni may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly.
Tell your doctor if you have ever had hepatitis B. Riabni can cause this condition to come back or get worse.
Severe skin problems can also occur during treatment with Riabni. Call your doctor if you have painful skin or mouth sores, or a severe skin rash with blistering, peeling, or pus.
Some side effects may occur during the injection or within 24 hours afterward. Tell your caregiver right away if you feel itchy, dizzy, weak, light-headed, short of breath, or if you have chest pain, wheezing, sudden cough, or pounding heartbeats or fluttering in your chest.
Before taking this medicine
Riabni may cause a serious brain infection that can lead to disability or death. This infection may be more likely if have used an immunosuppressant drug in the past, or if you have received this medicine with a stem cell transplant.
Tell your doctor if you have ever had:
liver disease or hepatitis (or if you are a carrier of hepatitis B);
an infection, including herpes, shingles, cytomegalovirus, chickenpox, parvovirus, West Nile virus, or hepatitis B or C;
lung disease or a breathing disorder;
a weak immune system (caused by disease or by using certain medicines);
heart disease, angina (chest pain), or heart rhythm disorder; or
if you have used Riabni in the past, or you have had a severe allergic reaction to this medicine.
You should be up-to-date on any needed immunizations before starting treatment with Riabni. Tell your doctor if you (or a child receiving this medicine) have received any vaccines within the past 4 weeks.
Do not use Riabni if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using Riabni and for at least 12 months after your last dose.
Do not breastfeed while using this medicine, and for at least 6 months after your last dose.
How is Riabni given?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using Riabni.
Riabni is given as an infusion into a vein. A healthcare provider will give you this injection.
Riabni is not given daily. Your schedule will depend on the condition being treated. Follow your doctor's dosing instructions very carefully.
Before each injection, you may be given other medications to prevent certain side effects of rituximab.
You will need frequent medical tests.
If you've ever had hepatitis B, using Riabni can cause this virus to become active or get worse. You may need frequent liver function tests while using this medicine and for several months after you stop.
If you need surgery, tell the surgeon ahead of time that you are using Riabni.
What happens if I miss a dose?
Call your doctor if you miss an appointment for your Riabni.
What happens if I overdose?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving Riabni?
Do not receive a "live" vaccine while using Riabni. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.
Riabni side effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).
Some side effects may occur during the injection (or within 24 hours afterward). Tell your caregiver right away if you feel itchy, dizzy, weak, light-headed, short of breath, or if you have chest pain, wheezing, sudden cough, or pounding heartbeats or fluttering in your chest.
Riabni may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have any of the following symptoms (which may start gradually and get worse quickly):
confusion, memory problems, or other changes in your mental state;
weakness on one side of your body;
vision changes; or
problems with speech or walking.
Call your doctor at once if you have any of these other side effects, even if they occur several months after you receive Riabni, or after your treatment ends.
painful skin or mouth sores, or a severe skin rash with blistering, peeling, or pus;
redness, warmth, or swelling of the skin;
irregular heartbeats, chest pain or pressure, pain spreading to your jaw or shoulder;
tiredness or jaundice (yellowing of the skin or eyes);
signs of infection--fever, chills, cold or flu symptoms, cough, sore throat, mouth sores, headache, earache, pain or burning when you urinate; or
Common side effects may include:
low white and red blood cells (fever, chills, body aches, pale skin, unusual tiredness, infections);
swelling in your hands or feet;
depressed mood; or
cold symptoms such as stuffy nose, sneezing, sore throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Riabni?
Tell your doctor about all your other medicines, especially:
medicines to treat conditions such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, or psoriasis--adalimumab, certolizumab, etanercept, golimumab, infliximab, leflunomide, methotrexate, sulfasalazine, tocilizumab, tofacitinib, and others.
Frequently asked questions
- What are the new drugs for the treatment of rheumatoid arthritis (RA)?
- How many biosimilars have been approved in the United States?
- What is the difference between Truxima and Rituxan?
- Are lung nodules common after Bendeka & Rituxan therapy?
- What is the difference between Rituxan and Rituxan Hycela?
More about Riabni (rituximab)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: CD20 monoclonal antibodies
- FDA Alerts (1)
- FDA Approval History
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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