How do I use the Tezspire pen?

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 1, 2024.

Official Answer by Drugs.com

Your healthcare provider can show you how to self-administer the Tezspire pen. Do not attempt to administer it yourself until you have received full instructions.

The usual dosage of Tezspire is 210mg (the contents of one pre-filled pen) administered under your skin (subcutaneously) once every 4 weeks.
Each Tezspire pre-filled pen contains 1 dose that can only be used 1 time. It is only given as an injection under the skin (subcutaneous).

To use the Tezspire pen:

Take it out of the refrigerator, and leave it in the carton and allow it to come to room temperature between 68°F to 77˚F (20°C to 25°C) for about 60 minutes before giving the injection. Do not remove the cap just yet
Do not warm the pre-filled pen in any other way. For example, do not warm it in a microwave or hot water, in direct sunlight, or near other heat sources
Do not put the injection back in the refrigerator after it has reached room temperature. Throw away (dispose of) Tezspire that has been stored at room temperature for more than 30 days
Check the pen for damage and check the expiry date. Do not use it if there is damage, the expiry date has passed, or if the solution looks cloudy, discolored, or contains large particles. The liquid should be clear and colorless to light yellow. Small air bubbles in the liquid are normal
Choose an injection site. If you are giving yourself the injection, the recommended site is the front of your thigh or the lower part of your stomach (abdomen). Do not inject yourself in the arm
A caregiver may inject you in the upper arm, thigh, or abdomen
For each injection, choose a different site that is at least 1 inch (3 cm) away from where you last injected
Do not inject:
- into the 2-inch (5 cm) area around your belly button
- where the skin is tender, bruised, scaly or hard
- into scars or damaged skin
- through clothing.
Wash your hands well with soap and water and clean the injection site with an alcohol wipe. Let it air dry.
Pull off the cap. You should see an orange needle guard. This is there to prevent you from touching the needle. Do not touch the needle or push on the orange needle guard with your finger.
Follow your healthcare provider’s instructions on how to inject. You can either gently pinch the skin at the injection site or give the injection without pinching the skin.
Inject Tezspire by holding it straight up and down (at a 90-degree angle) to your skin. Press down firmly so you cannot see the needle guard. You will hear the first click that tells you the injection has started. Press and hold the pre-filled pen for 15 seconds until you hear the second click.
Do not change the position of the pre-filled pen after the injection has started.
Once you have completed the injection, lift the pen straight up. The orange plunger should fill the viewing window. If it does not, contact your healthcare provider because you may not have received a full dose.
Cover the injection site with a small bandage if needed. Do not rub the injection site. Dispose of the used pen in an FDA-approved sharps container.

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