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Generic name: tezepelumab-ekko
Dosage form: injection, for subcutaneous use
Drug class: Selective immunosuppressants

Medically reviewed by Judith Stewart, BPharm. Last updated on Jan 24, 2022.

What is Tezspire?

Tezspire is a prescription medicine used with other asthma medicines for the maintenance treatment of severe asthma in people 12 years of age and older whose asthma is not controlled with their current asthma medicine.

Tezspire helps prevent severe asthma attacks (exacerbations) and can improve your breathing.

Tezspire is not used to treat sudden breathing problems. Tell your healthcare provider if your asthma does not get better or if it gets worse after you start treatment with Tezspire.

It is not known if this medicine is safe and effective in children under 12 years of age.

Who should not receive Tezspire?

You should not receive Tezspire if you:

  • are allergic to tezepelumab or any of the other ingredients. See the end of this page for a complete list of ingredients.

Before receiving Tezspire

Before you receive Tezspire, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction (hypersensitivity).
  • have a parasitic (helminth) infection.
  • have recently received or are scheduled to receive any live attenuated vaccinations. People who receive Tezspire should not receive live attenuated vaccines.
  • are pregnant, think you may be pregnant, or plan to become pregnant. It is not known if Tezspire may harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Tezspire passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you receive Tezspire.

What other drugs will affect Tezspire?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not change or stop your corticosteroid medicines or other asthma medicines unless your healthcare provider tells you to.

How will I receive Tezspire?

  • Your healthcare provider will give you Tezspire in a healthcare setting.
  • Tezspire is injected under your skin (subcutaneously) 1 time every 4 weeks.
  • If you miss an appointment, ask your healthcare provider when to schedule your next treatment.

Dosage information

- 210 mg administered by subcutaneous injection once every 4 weeks

- Use: add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma

Tezspire side effects

Tezspire may cause serious side effects, including:

  • severe allergic reactions. Call your healthcare provider or get emergency medical care if you get any of the following symptoms of allergic reaction:
    • rash
    • hives
    • breathing problems
    • red, itchy, swollen, or inflamed eyes

The most common side effects include:

  • sore throat (pharyngitis)
  • joint pain (arthralgia)
  • back pain

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

General information about the safe and effective use of Tezspire

Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. You can ask your pharmacist or healthcare provider for information that is written for health professionals.

What are the ingredients in Tezspire?

Active ingredient: tezepelumab-ekko
Inactive ingredients: glacial acetic acid, L-proline, polysorbate 80, sodium hydroxide, and water for injection

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.