Tezspire Side Effects

Generic name: tezepelumab

Medically reviewed by Drugs.com. Last updated on May 25, 2024.

Note: This document provides detailed information about Tezspire Side Effects associated with tezepelumab. Some dosage forms listed on this page may not apply specifically to the brand name Tezspire.

Applies to tezepelumab: subcutaneous solution.

Common side effects of Tezspire

Some side effects of tezepelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• back pain
• body aches or pain
• cough
• difficulty in moving
• dryness or soreness of the throat
• fever
• muscle pain or stiffness
• redness, pain, or itching at the injection site
• stuffy or runny nose
• tender, swollen glands in the neck
• trouble swallowing
• voice changes

Serious side effects of Tezspire

Along with its needed effects, tezepelumab (the active ingredient contained in Tezspire) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tezepelumab:

Incidence not known

• burning, dry, or itching eyes
• chest tightness
• discharge, excessive tearing
• fast heartbeat
• hives, itching, skin rash
• hoarseness
• irritation
• joint pain, stiffness, or swelling
• lightheadedness, dizziness, or fainting
• redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
• redness of the skin
• swelling of the eyelids, face, lips, mouth, tongue, hands, or feet
• trouble breathing

For healthcare professionals

Applies to tezepelumab: subcutaneous solution.

General adverse events

The most common adverse reactions included pharyngitis, arthralgia, and back pain. The safety profile in pediatric patients was generally similar to the overall study population.^[Ref]

Cardiovascular

• Frequency not reported: MACE (major adverse cardiovascular events)

One clinical trial observed higher incidence rates per 100 patient-years for both serious cardiac adverse events and MACE in patients treated with this drug as compared to placebo; however, the clinical implications of these findings were not described by the manufacturer.

Dermatologic

• Common (1% to 10%): Rash

Rash included rash, pruritic rash, erythematous rash, maculopapular rash, and macular rash.

Hypersensitivity

• Postmarketing reports: Anaphylaxis

Immunologic

• Common (1% to 10%): Anti-drug antibodies

Local

• Common (1% to 10%): Injection site reactions

Injection site reactions included injection site erythema, injection site swelling, and injection site pain.

In one clinical study, injection site reactions were observed in a higher percentage of patients who used the prefilled pen (5.7%) versus the prefilled syringe (0%).

Musculoskeletal

• Common (1% to 10%): Arthralgia, back pain

Respiratory

• Common (1% to 10%): Pharyngitis

Pharyngitis included pharyngitis, bacterial pharyngitis, streptococcal pharyngitis, and viral pharyngitis.

Frequently asked questions

• What are 5 key Tezspire side effects to watch out for?
• Does Tezspire cause weight gain?
• How do I use the Tezspire pen?

Further information

Tezspire side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer