Tezspire Side Effects

Generic name: tezepelumab

Medically reviewed by Drugs.com. Last updated on May 25, 2024.

Note: This document provides detailed information about Tezspire Side Effects associated with tezepelumab. Some dosage forms listed on this page may not apply specifically to the brand name Tezspire.

Applies to tezepelumab: subcutaneous solution.

Precautions

It is very important that your doctor check your or your child's progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis or allergic conjunctivitis, which can be serious and can occur within hours or days after receiving the injection. Tell your doctor right away if you have hives, itching, skin rash, lightheadedness, dizziness, fainting, swelling of the face, mouth, or tongue, trouble breathing, burning, dry, or itching eyes, discharge, excessive tearing, or redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid after using this medicine.

If you are using a steroid medicine for your asthma, do not suddenly stop taking it without first checking with your doctor. You may need to slowly decrease your dose before stopping it completely.

Do not receive any live vaccines (immunizations) while you are being treated with tezepelumab-ekko. Check with your doctor before receiving any vaccines.

Common side effects of Tezspire

Some side effects of tezepelumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Tezspire

Along with its needed effects, tezepelumab (the active ingredient contained in Tezspire) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tezepelumab:

For healthcare professionals

Applies to tezepelumab: subcutaneous solution.

General adverse events

The most common adverse reactions included pharyngitis, arthralgia, and back pain. The safety profile in pediatric patients was generally similar to the overall study population.^[Ref]

Cardiovascular

• Frequency not reported: MACE (major adverse cardiovascular events)

One clinical trial observed higher incidence rates per 100 patient-years for both serious cardiac adverse events and MACE in patients treated with this drug as compared to placebo; however, the clinical implications of these findings were not described by the manufacturer.

Dermatologic

• Common (1% to 10%): Rash

Rash included rash, pruritic rash, erythematous rash, maculopapular rash, and macular rash.

Hypersensitivity

• Postmarketing reports: Anaphylaxis

Immunologic

• Common (1% to 10%): Anti-drug antibodies

Local

• Common (1% to 10%): Injection site reactions

Injection site reactions included injection site erythema, injection site swelling, and injection site pain.

In one clinical study, injection site reactions were observed in a higher percentage of patients who used the prefilled pen (5.7%) versus the prefilled syringe (0%).

Musculoskeletal

• Common (1% to 10%): Arthralgia, back pain

Respiratory

• Common (1% to 10%): Pharyngitis

Pharyngitis included pharyngitis, bacterial pharyngitis, streptococcal pharyngitis, and viral pharyngitis.

See also:

Frequently asked questions

• What are 5 key Tezspire side effects to watch out for?
• Does Tezspire cause weight gain?
• How do I use the Tezspire pen?

Further information

Tezspire side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer