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How does Yosprala work?

Medically reviewed by Last updated on Nov 20, 2019.

Official Answer


Yosprala (aspirin and omeprazole) first delivers immediate-release omeprazole (40 mg) followed by a delayed-release, enteric-coated aspirin core in either 81 mg or 325 mg dose strengths.

The enteric-coated aspirin dissolves after the stomach pH reaches 5.5, or greater to reduce ulcer risk.

Yosprala is used in patients who require aspirin to help prevent a recurrence of heart attack or stroke, and who are at risk of developing gastric (stomach) ulcers due to aspirin use.

Yosprala is a combination antiplatelet and proton pump inhibitor from Aralez Pharmaceuticals.

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