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Prednisone vs Prednisolone - What's the difference?

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 16, 2024.

Official Answer by Drugs.com

The main difference between prednisone and prednisolone is that prednisone must be converted by liver enzymes to prednisolone before it can work.

Both prednisone and prednisolone are man-made glucocorticoids. They are used to treat similar conditions and are generally considered equally effective. Other similarities include:

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