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Learn about Amitiza, a treatment of Chronic Constipation

Symproic (naldemedine) Drug Interactions

A total of 141 drugs are known to interact with Symproic (naldemedine).

  • 23 major drug interactions
  • 118 moderate drug interactions

Show all medications in the database that may interact with Symproic (naldemedine).

Check for interactions with Symproic (naldemedine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Symproic (naldemedine)

  • atorvastatin (Lipitor)
  • baclofen (Lioresal, Gablofen, Kemstro, Lioresal Intrathecal)
  • Belbuca (buprenorphine)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • Cymbalta (duloxetine)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Unithroid, Levothyrox, Euthyrox, Levo-T, L Thyroxine Roche, Eutroxsig, Novothyrox, Oroxine, Tirosint-Sol, Levotabs, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • Lyrica (pregabalin)
  • Norco (acetaminophen / hydrocodone)
  • oxycodone (OxyContin, Roxicodone, Xtampza ER, OxyIR, Oxaydo, Percolone, Oxyfast, Oxydose, RoxyBond, Dazidox, Oxecta, M-Oxy, ETH-Oxydose, Endocodone, Roxicodone Intensol)
  • pantoprazole (Protonix, Protonix IV)
  • prednisone (Deltasone, Rayos, Sterapred, Sterapred DS, Prednicot, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • promethazine (Phenergan, Promethegan, Phenadoz, Antinaus 50, Anergan 50, Adgan, Phenazine 50, Phenergan Fortis, V-Gan-50, V-Gan-25, Phenoject-50, Pro-Med)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Deprizine, Zantac Injection, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • tizanidine (Zanaflex)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D3 (cholecalciferol)

Symproic (naldemedine) alcohol/food interactions

There is 1 alcohol/food interaction with Symproic (naldemedine)

Symproic (naldemedine) disease interactions

There is 1 disease interaction with Symproic (naldemedine):

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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