Drug Interactions between Linzess and Symproic
This report displays the potential drug interactions for the following 2 drugs:
- Linzess (linaclotide)
- Symproic (naldemedine)
Interactions between your drugs
No interactions were found between Linzess and Symproic. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
Linzess
A total of 59 drugs are known to interact with Linzess.
- Linzess is in the drug class guanylate cyclase-C agonists.
- Linzess is used to treat the following conditions:
Symproic
A total of 170 drugs are known to interact with Symproic.
- Symproic is in the drug class peripheral opioid receptor antagonists.
- Symproic is used to treat Opioid-Induced Constipation.
Drug and food interactions
linaclotide food
Applies to: Linzess (linaclotide)
Taking linaclotide with food may increase gastrointestinal side effects such as diarrhea, abdominal pain, and gas. The absorption of any other oral medication you may take can be affected if you develop frequent or severe diarrhea. To reduce the risk of gastrointestinal intolerance, linaclotide should be taken on an empty stomach at least 30 minutes prior to the first meal of the day. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
naldemedine food
Applies to: Symproic (naldemedine)
Grapefruit juice can increase the blood levels of naldemedine. This may increase side effects and withdrawal symptoms such as sweating, tearing, runny nose, chills, diarrhea, abdominal pain, anxiety, insomnia, irritability, restlessness, and yawning. You should limit the consumption of grapefruit and grapefruit juice during treatment with naldemedine. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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