Depakote Drug Interactions
Currently displaying a list of 425 drugs known to interact with Depakote (divalproex sodium).
- 24 major drug interactions
- 378 moderate drug interactions
- 23 minor drug interactions
Medications known to interact with Depakote
Note: Showing generic names only.
A
- acetylcarbromal
- acrivastine
- alfentanil
- allopurinol
- alprazolam
- aluminum carbonate
- aluminum hydroxide
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- anisindione
- apalutamide
- apixaban
- apomorphine
- apraclonidine ophthalmic
- aripiprazole
- artesunate
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- aspirin
- azatadine
- azelastine nasal
B
- baclofen
- bedaquiline
- belzutifan
- benoxinate ophthalmic
- benzocaine topical
- benztropine
- bexarotene
- binimetinib
- biperiden
- bismuth subsalicylate
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- calaspargase pegol
- calcium carbonate
- cannabidiol
- cannabis
- capivasertib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- celecoxib
- cenobamate
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cholestyramine
- choline salicylate
- cimetidine
- cisplatin
- citalopram
- clarithromycin
- clemastine
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cocaine nasal
- cocaine topical
- codeine
- conjugated estrogens
- conjugated estrogens topical
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dabigatran
- daclizumab
- dantrolene
- daridorexant
- darifenacin
- dehydroepiandrosterone
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dienestrol topical
- diethylstilbestrol
- difelikefalin
- diflunisal
- dihydroxyaluminum sodium carbonate
- dimenhydrinate
- diphenhydramine
- doripenem
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- drospirenone
- duloxetine
E
- efavirenz
- encorafenib
- ensifentrine
- entacapone
- epirubicin
- ertapenem
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esomeprazole
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etonogestrel
- etranacogene dezaparvovec
- etravirine
- evening primrose
- ezogabine
F
- felbamate
- fenfluramine
- fentanyl
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- folic acid
- fosphenytoin
G
H
- halazepam
- haloperidol
- heroin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
I
- ibuprofen
- idelalisib
- iloperidone
- imipramine
- interferon beta-1a
- interferon beta-1b
- isocarboxazid
- isoniazid
K
L
- l-methylfolate
- lamotrigine
- lasmiditan
- leflunomide
- lemborexant
- lesinurad
- leucovorin
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levoleucovorin
- levomefolate calcium
- levomethadyl acetate
- levomilnacipran
- levonorgestrel
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- lithium
- lofexidine
- lomitapide
- lonafarnib
- lorazepam
- loxapine
- lumateperone
- lurasidone
M
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium salicylate
- maprotiline
- meclizine
- medroxyprogesterone
- mefloquine
- megestrol
- melatonin
- meloxicam
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- meropenem
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methsuximide
- methyldopa
- metoclopramide
- metyrosine
- midazolam
- milnacipran
- mipomersen
- mirtazapine
- mitotane
- molindone
- montelukast
- morphine
- morphine liposomal
- multivitamin, prenatal
N
- nabilone
- nalbuphine
- naltrexone
- nateglinide
- nefazodone
- nifedipine
- nimodipine
- nitazoxanide
- norethindrone
- norgestrel
- nortriptyline
O
- olanzapine
- oliceridine
- olopatadine nasal
- opicapone
- opium
- orlistat
- orphenadrine
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
P
- paliperidone
- paraldehyde
- paramethadione
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pemoline
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phenytoin
- pimozide
- pitolisant
- pivmecillinam
- pramipexole
- pramoxine topical
- pregabalin
- primidone
- procaine
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- protriptyline
- pyrilamine
Q
R
- ramelteon
- rasagiline
- regorafenib
- remdesivir
- remifentanil
- remimazolam
- rifampin
- risperidone
- ritonavir
- rivaroxaban
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salsalate
- scopolamine
- secobarbital
- selegiline
- selexipag
- sertraline
- sibutramine
- sodium bicarbonate
- sodium citrate
- sodium oxybate
- sodium phenylacetate
- sodium phenylbutyrate
- sodium salicylate
- sodium thiosalicylate
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
T
- tafamidis
- tapentadol
- tasimelteon
- temazepam
- temozolomide
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- tipranavir
- tirzepatide
- tizanidine
- tolbutamide
- tolcapone
- topiramate
- torsemide
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troleandomycin
V
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- vardenafil
- venlafaxine
- vigabatrin
- vilazodone
- vorinostat
- vortioxetine
W
Z
Depakote alcohol/food interactions
There is 1 alcohol/food interaction with Depakote (divalproex sodium).
Depakote disease interactions
There are 8 disease interactions with Depakote (divalproex sodium) which include:
- depression
- liver disease
- urea cycle disorders
- suicidal tendency
- HIV/CMV
- thrombocytopenia
- thyroid function tests
- urine ketone test
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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