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Drug Interactions between Depakote and phenobarbital

This report displays the potential drug interactions for the following 2 drugs:

  • Depakote (divalproex sodium)
  • phenobarbital

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Interactions between your drugs


PHENobarbital divalproex sodium

Applies to: phenobarbital and Depakote (divalproex sodium)

Before taking divalproex sodium, tell your doctor if you also use PHENobarbital. You may need dose adjustments or special tests in order to safely take both medications together. This combination may increase the levels of PHENobarbital in your body. You should notify your doctor if you have symptoms of excessive sedation or lethargy. You should avoid driving until you know how these medications will affect you. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

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Drug and food interactions


divalproex sodium food

Applies to: Depakote (divalproex sodium)

Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with divalproex sodium. Do not use more than the recommended dose of divalproex sodium, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.