Naldemedine Disease Interactions
There are 3 disease interactions with naldemedine:
Naldemedine (applies to naldemedine) hepatic impairment
Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
The use of naldemedine should be avoided in patients with severe hepatic impairment. No dose adjustment is required in patients with mild or moderate hepatic impairment.
Peripheral opioid receptor antagonists (applies to naldemedine) intestinal obstruction
Major Potential Hazard, Moderate plausibility. Applicable conditions: Diverticulitis, Peptic Ulcer, Inflammatory Bowel Disease, Gastrointestinal Obstruction
Peripheral opioid receptor antagonists are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for gastrointestinal perforation. Cases of gastrointestinal perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. It is recommended to monitor for the development of severe, persistent, or worsening abdominal pain and to discontinue treatment in patients who develop symptoms. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.
Naldemedine (applies to naldemedine) hemodialysis
Moderate Potential Hazard, Moderate plausibility.
Naldemedine is not removed from the blood by hemodialysis. Plasma concentrations of naldemedine in subjects with ESRD requiring hemodialysis were similar when the drug was administered either pre- or post-hemodialysis.
Naldemedine drug interactions
There are 141 drug interactions with naldemedine
Naldemedine alcohol/food interactions
There is 1 alcohol/food interaction with naldemedine
More about naldemedine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 21 Reviews
- Drug class: peripheral opioid receptor antagonists
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|