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Naldemedine Dosage

Medically reviewed by Last updated on Mar 29, 2024.

Applies to the following strengths: 0.2 mg

Usual Adult Dose for Constipation - Drug Induced

0.2 mg orally once a day


Use: Treatment of opioid-induced constipation (OIC) in patients with chronic, non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Mild and moderate liver dysfunction (Child-Pugh class A and B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh class C): Not recommended.

Dose Adjustments

Suspicion of obstruction/perforation in patients with severe, persistent, and/or worsening abdominal pain: This drug should be discontinued.



Safety and efficacy have not been established in pediatric patients.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Storage requirements:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.