Medically reviewed on November 9, 2017.
Applies to the following strengths: 0.2 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Constipation - Drug Induced
0.2 mg orally once a day
-Discontinue therapy if treatment with the opioid pain medication is discontinued.
Use: For the treatment of opioid-induced constipation in adults with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g. weekly) opioid dosage escalation.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
Mild to moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment: Avoid use
There are clinically important drug interactions (i.e., CYP450 3A4 inducers, CYP450 3A4 inhibitors, P-gp inhibitors, other opioid antagonists): Consult drug interactions for guidance
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Hemodialysis: No adjustment recommended
Peritoneal dialysis: Data not available
-Take orally once a day with or without food
-Protect from light
-Patients receiving opioids for less than 4 weeks prior to starting this drug may be less responsive.
-Changes to opioid analgesics are not required prior to starting this drug.
-This drug should be discontinued if treatment with the opioid pain medication is discontinued.
-Monitor for abdominal pain
-Monitor for opioid withdrawal symptoms
-Patients should be instructed to stop this drug if they stop taking their opioid pain medication.
-Patients should be instructed to promptly stop this drug and seek medical attention if they develop unusually severe, persistent, or worsening abdominal pain.
-Patients should be instructed to contact their healthcare professional if they experience opioid withdrawal symptoms.
-Patients should be instructed to speak with a healthcare professional before taking any new or over-the-counter medications, or herbal supplements, as other medications may affect the way this drug works.
-Patients should be instructed to speak to their healthcare provider if pregnant, intend to become pregnant, or are breastfeeding.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: peripheral opioid receptor antagonists
Other brands: Symproic