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Ixekizumab Disease Interactions

There are 4 disease interactions with ixekizumab:

Moderate

Ixekizumab (Includes Ixekizumab) ↔ Infections

Moderate Potential Hazard, Moderate plausibility

Applies to: Infection - Bacterial/Fungal/Protozoal/Viral

Upper respiratory tract infections, oral candidiasis, conjunctivitis, and tinea infections have occurred with the use of ixekizumab. Close monitoring or discontinuation of therapy is recommended in patients with serious infections that do not respond to conventional treatment. It is recommended to restart therapy only until the infection resolves.

Moderate

Ixekizumab (Includes Ixekizumab) ↔ Inflammatory Bowel Disease

Moderate Potential Hazard, Moderate plausibility

Applies to: Inflammatory Bowel Disease

Crohn's disease and ulcerative colitis, including exacerbations have occurred during ixekizumab treatment. Caution and close monitoring for onset or exacerbation of inflammatory bowel disease are recommended.

Moderate

Ixekizumab (Includes Ixekizumab) ↔ Tuberculosis

Moderate Potential Hazard, Moderate plausibility

Applies to: Tuberculosis -- Active, History - Tuberculosis, Tuberculosis -- Latent

Patients should be evaluated for tuberculosis (TB) infection prior to ixekizumab treatment. It is recommended to initiate treatment of latent TB prior to administering ixekizumab and to consider anti-TB therapy prior to initiating therapy in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Do not administer this agent to patients with active TB infection. Patients should be monitored closely for signs and symptoms of active TB during and after treatment.

Moderate

Ixekizumab (Includes Ixekizumab) ↔ Renal/Hepatic Impairment

Minor Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction, Liver Disease

No formal clinical studies of the effect of hepatic or renal impairment on the pharmacokinetics of ixekizumab have been conducted. Care should be taken when prescribing this drug to these patients.

ixekizumab drug Interactions

There are 268 drug interactions with ixekizumab

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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