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Dobutrex (dobutamine) Disease Interactions

There are 5 disease interactions with Dobutrex (dobutamine):

Major

Dobutamine (Includes Dobutrex) ↔ Asthmatics

Severe Potential Hazard, Moderate plausibility

Applies to: Asthma

Dobutamine injection contains sodium metabisulfite, a sulfite that may cause anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible people, such as asthmatic patients.

Major

Dobutamine/Arbutamine (Includes Dobutrex) ↔ Arrhythmias

Severe Potential Hazard, High plausibility

Applies to: Arrhythmias, Hypertension, Heart Block

Dobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

References

  1. Bianchi C, Diaz R, Gonzales C, Beregovich J "Effects of dobutamine on atrioventricular conduction." Am Heart J 90 (1975): 474-8
  2. "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company, Indianapolis, IN.
  3. Kinder C, Chamberlain J, Kall J, Kopp D, Johnson M, Costanzo MR, Wilber D "Prognostic significance of sustained ventricular tachyarrhythmia occurring during dobutamine infusion." J Heart Lung Transplant 13 (1994): 1045-50
View all 10 references
Major

Dobutamine/Arbutamine (Includes Dobutrex) ↔ Hypotension

Severe Potential Hazard, High plausibility

Applies to: Hypotension, Dehydration

The use of dobutamine and arbutamine has been infrequently associated with significant hypotension especially in dehydrated patients secondary to beta-2 mediated vasodilation. Hypovolemia should be corrected before administering dobutamine or arbutamine. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.

References

  1. Heinle SK, Tice FD, Kisslo J "Hypotension during dobutamine stress echocardiography: is it related to dynamic intraventricular obstruction?" Am Heart J 130 (1995): 314-7
  2. "Product Information. GenESA (arbutamine)." Gensia Inc, San Diego, CA.
  3. Rosamond TL, Vacek JL, Hurwitz A, Rowland AJ, Beauchamp GD, Crouse LJ "Hypotension during dobutamine stress echocardiography: initial description and clinical relevance." Am Heart J 123 (1992): 403-7
View all 4 references
Major

Dobutamine/Arbutamine (Includes Dobutrex) ↔ Ihss

Severe Potential Hazard, High plausibility

Applies to: Hypertrophic Cardiomyopathy

The use of dobutamine or arbutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS). Dobutamine or arbutamine may increase the pressure gradient within the left ventricle and thereby worsen cardiac output in patients with IHSS.

References

  1. "Product Information. GenESA (arbutamine)." Gensia Inc, San Diego, CA.
Moderate

Dobutamine (Includes Dobutrex) ↔ Hypokalemia

Moderate Potential Hazard, Moderate plausibility

Applies to: Hypokalemia

The use of dobutamine has been associated with hypokalemia. Therapy with dobutamine should be administered cautiously to patients with hypokalemia. Frequent monitoring of serum potassium along with appropriate electrolyte replacement is recommended.

Dobutrex (dobutamine) drug Interactions

There are 249 drug interactions with Dobutrex (dobutamine)

Dobutrex (dobutamine) alcohol/food Interactions

There is 1 alcohol/food interaction with Dobutrex (dobutamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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