Dobutrex Side Effects
Generic name: dobutamine
Medically reviewed by Drugs.com. Last updated on Mar 2, 2022.
Note: This document contains side effect information about dobutamine. Some dosage forms listed on this page may not apply to the brand name Dobutrex.
Applies to dobutamine: parenteral concentrate for injection for iv infusion, parenteral injection in 5% dextrose for iv infusion.
A standardized concentration for this drug has been established through Standardize 4 Safety (S4S), a national patient safety initiative to reduce medication errors, especially during transitions of care. The drug is included in a standard concentration list which may apply to an IV or oral compounded liquid formulation. For additional information, see the ASHP website [Web].
Side effects include:
Ectopic heartbeats, increased heart rate, elevations in BP, hypotension, phlebitis, local inflammatory changes.
For Healthcare Professionals
Applies to dobutamine: intravenous solution.
The most common adverse reaction was heart rate increased by 30 beats per minute or more.[Ref]
Very common (10% or more): Heart rate increased by 30 beats per minute (bpm) or more (10%)
Common (1% to 10%): Systolic blood pressure increased by 50 mmHg or more, premature ventricular beats increased, anginal pain, palpitations, blood pressure decreased, ventricular dysrhythmia, dose-dependent ventricular extrasystoles, ventricular frequency increased in patients with atrial fibrillation, vasoconstriction in patients previously treated with beta blockers, supraventricular extrasystoles, ventricular tachycardia
Uncommon (0.1% to 1%): Ventricular fibrillation
Very rare (less than 0.01%): Bradycardia, myocardial ischemia, myocardial infarction, cardiac arrest, second degree atrioventricular block, coronary vasospasms, hypertensive/hypotensive blood pressure decompensation, intracavitary pressure gradients
Frequency not reported: Systolic blood pressure increased by 10 to 20 mmHg, heart rate increased by 5 to 15 bpm, blood pressure decreased precipitously, pulmonary capillary pressure decreased, pectoral anginal discomfort, stress cardiomyopathy, eosinophilic myocarditis, fatal cardiac rupture[Ref]
Common (1% to 10%): Exanthema, skin rash
Very rare (less than 0.01%): Petechial bleeding
Common (1% to 10%): Phlebitis, inflammation
Very rare (less than 0.01%): Cutaneous necrosis[Ref]
Common (1% to 10%): Eosinophilia, thrombocyte aggregation inhibited when continuing infusion over a number of days
Common (1% to 10%): Nonspecific chest pain, fever
Common (1% to 10%): Shortness of breath, bronchospasm[Ref]
Common (1% to 10%): Headache
Frequency not reported: Paresthesia, tremor[Ref]
Common (1% to 10%): Urgency increased at high doses of infusion
Frequency not reported: Urinary urgency[Ref]
Very rare (less than 0.01%): Hypokalemia
Frequency not reported: Serum potassium decreased[Ref]
Frequency not reported: Hypersensitivity[Ref]
Frequency not reported: Myoclonic spasm[Ref]
Frequency not reported: Restlessness, anxiety[Ref]
More about Dobutrex (dobutamine)
- Check interactions
- Dosage information
- During pregnancy
- Drug class: cardiac stressing agents
- En español
Related treatment guides
1. "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company (2002):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.