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Dobutrex Disease Interactions

There are 5 disease interactions with Dobutrex (dobutamine).

Major

Dobutamine (applies to Dobutrex) asthmatics

Major Potential Hazard, Moderate plausibility.

Dobutamine injection contains sodium metabisulfite, a sulfite that may cause anaphylactic symptoms and life-threatening or less severe asthmatic episodes in susceptible people, such as asthmatic patients.

References (1)
  1. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company
Major

Dobutamine/arbutamine (applies to Dobutrex) arrhythmias

Major Potential Hazard, High plausibility. Applicable conditions: Hypertension

Dobutamine and arbutamine produce stimulation of the beta receptors of the heart. The use of these agents has been associated with an increase in heart rate, ventricular ectopy, atrial fibrillation, hypertension, enhanced A-V conduction, and arrhythmias. Therapy with dobutamine or arbutamine should be administered cautiously in patients with cardiac conduction disorders.

References (10)
  1. Bianchi C, Diaz R, Gonzales C, Beregovich J (1975) "Effects of dobutamine on atrioventricular conduction." Am Heart J, 90, p. 474-8
  2. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company
  3. Baudhuin T, Marwick T, Melin J, Wijns W, D'Hondt AM, Detry JM (1993) "Diagnosis of coronary artery disease in elderly patients: safety and efficacy of dobutamine echocardiography." Eur Heart J, 14, p. 799-803
  4. Poldermans D, Fioretti PM, Boersma E, Forster T, Vanurk H, Cornel JH, Arnese M, Roelandt JRTC (1994) "Safety of dobutamine-atropine stress echocardiography in patients with suspected or proven coronary artery disease." Am J Cardiol, 73, p. 456-9
  5. Picano E, Mathias W, Pingitore A, Bigi R, Previtali M (1994) "Safety and tolerability of dobutamine-atropine stress echocardiography: a prospective, multicentre study." Lancet, 344, p. 1190-2
  6. Kinder C, Chamberlain J, Kall J, Kopp D, Johnson M, Costanzo MR, Wilber D (1994) "Prognostic significance of sustained ventricular tachyarrhythmia occurring during dobutamine infusion." J Heart Lung Transplant, 13, p. 1045-50
  7. Cohen A, Chauvel C, Benhalima B, Blanchard B (1995) "Complication of dobutamine stress echocardiography." Lancet, 345, p. 201-2
  8. Tisdale JE, Patel R, Webb CR, Borzak S, Zarowitz BJ (1995) "Electrophysiologic and proarrhythmic effects of intravenous inotropic agents." Prog Cardiovasc Dis, 38, p. 167-80
  9. Previtali M, Lanzarini L, Fetiveau R, Poli A, Diotallevi P (1996) "Dobutamine-induced and spontaneous sustained ventricular tachycardia in recent myocardial infarction." Eur Heart J, 17, p. 803-4
  10. (2001) "Product Information. GenESA (arbutamine)." Gensia Inc
Major

Dobutamine/arbutamine (applies to Dobutrex) hypotension

Major Potential Hazard, High plausibility. Applicable conditions: Dehydration

The use of dobutamine and arbutamine has been infrequently associated with significant hypotension especially in dehydrated patients secondary to beta-2 mediated vasodilation. Hypovolemia should be corrected before administering dobutamine or arbutamine. Blood pressure and ECG should be monitored at regular intervals. Monitoring of cardiac output and pulmonary wedge pressure may also be desired.

References (4)
  1. Rosamond TL, Vacek JL, Hurwitz A, Rowland AJ, Beauchamp GD, Crouse LJ (1992) "Hypotension during dobutamine stress echocardiography: initial description and clinical relevance." Am Heart J, 123, p. 403-7
  2. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company
  3. Heinle SK, Tice FD, Kisslo J (1995) "Hypotension during dobutamine stress echocardiography: is it related to dynamic intraventricular obstruction?" Am Heart J, 130, p. 314-7
  4. (2001) "Product Information. GenESA (arbutamine)." Gensia Inc
Major

Dobutamine/arbutamine (applies to Dobutrex) IHSS

Major Potential Hazard, High plausibility. Applicable conditions: Hypertrophic Cardiomyopathy

The use of dobutamine or arbutamine is contraindicated in patients with idiopathic hypertrophic subaortic stenosis (IHSS). Dobutamine or arbutamine may increase the pressure gradient within the left ventricle and thereby worsen cardiac output in patients with IHSS.

References (2)
  1. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company
  2. (2001) "Product Information. GenESA (arbutamine)." Gensia Inc
Moderate

Dobutamine (applies to Dobutrex) hypokalemia

Moderate Potential Hazard, Moderate plausibility.

The use of dobutamine has been associated with hypokalemia. Therapy with dobutamine should be administered cautiously to patients with hypokalemia. Frequent monitoring of serum potassium along with appropriate electrolyte replacement is recommended.

References (1)
  1. (2002) "Product Information. Dobutrex (dobutamine)." Lilly, Eli and Company

Switch to consumer interaction data

Dobutrex drug interactions

There are 176 drug interactions with Dobutrex (dobutamine).

Dobutrex alcohol/food interactions

There are 2 alcohol/food interactions with Dobutrex (dobutamine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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