Generic Name: cenobamate (Oral route)
Medically reviewed by Drugs.com. Last updated on Mar 17, 2019.
Commonly used brand name(s)
In the U.S.
Chemical Class: Carbamate
Uses for XCOPRI
Cenobamate is used to control partial-onset seizures (convulsions) in the treatment of epilepsy.
Cenobamate belongs to a class of medicines called anticonvulsants. It acts in the brain to prevent seizures. However, this medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to take it.
This medicine is available only with your doctor's prescription.
Before using XCOPRI
Appropriate studies have not been performed on the relationship of age to the effects of cenobamate in the pediatric population. Safety and efficacy have not been established.
Although appropriate studies on the relationship of age to the effects of cenobamate have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution and an adjustment in the dose for patients receiving cenobamate.
Interactions with medicines
Interactions with food/tobacco/alcohol
Other medical problems
- Depression or
- Drug abuse or dependence or
- Heart rhythm problems (eg, QT shortening) or
- Mental illness—Use with caution. May make these conditions worse.
- Heart rhythm problems (eg, familial short QT syndrome)—Should not be used in patients with this condition.
- Kidney disease, end stage or
- Liver disease, severe—Use is not recommended in patients with these conditions.
- Kidney disease, mild to severe or
- Liver disease, mild to moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of XCOPRI
Take this medicine only as directed by your doctor, to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Swallow the tablet whole. Do not crush, break, or chew it. You may take this medicine with or without food.
This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.
- For oral dosage form (tablets):
- For partial-onset seizures:
- Adults—12.5 milligrams (mg) once a day for 2 weeks. Your doctor will gradually increase your dose every 2 weeks. However, the dose is usually not more than 400 mg per day.
- Children—Use and dose must be determined by your doctor.
- For partial-onset seizures:
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions while using XCOPRI
It is very important that your doctor check your progress at regular visits. This is necessary to allow dose adjustments and to check for serious unwanted effects.
Serious skin reactions (including drug reaction with eosinophilia and systemic symptoms (DRESS) may occur during treatment with cenobamate. Tell your doctor right away if you have a fever, skin rashes or blisters, or swollen, painful, or tender lymph glands in neck, armpit, or groin while using this medicine.
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast or uneven heartbeat that last a long time. These may be symptoms of a heart rhythm problem called QT shortening.
If you develop any unusual or strange thoughts and behavior while taking this medicine, be sure to discuss it with your doctor. Other changes might be confusion, worsening of depression, suicidal thoughts, and unusual excitement, nervousness, or irritability.
Cenobamate may cause blurred vision, double vision, or other changes in vision. It may also cause some people to become dizzy, drowsy, clumsy, or feel tired. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to see well.
Do not stop taking cenobamate without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping completely. Stopping the medicine suddenly may cause your seizures to return or to occur more often.
This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, barbiturates, medicine for seizures, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor or dentist before taking any of the above while you are taking this medicine.
Birth control pills may not work while you are using cenobamate. To keep from getting pregnant, use another form of birth control including condoms, diaphragms, or contraceptive foams or jellies.
XCOPRI side effects
Check with your doctor immediately if any of the following side effects occur:
- Fast, irregular, pounding, or racing heartbeat or pulse
Incidence not known
- Black, tarry stools
- bloody or cloudy urine
- changes in behavior
- chest pain or discomfort
- dark urine
- difficulty in breathing
- false or unusual sense of well-being
- fast heartbeat
- feeling sad or empty
- general tiredness and weakness
- lack of appetite
- light-colored stools
- loss of interest or pleasure
- muscle pain
- nausea and vomiting
- painful or difficult urination
- rash sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swelling of the face, feet, or lower legs
- swollen glands
- swollen, painful, or tender lymph glands in the neck, armpit, or groin
- thoughts of killing oneself
- trouble concentrating
- trouble sleeping
- unusual tiredness or weakness
- unusual weight gain
- upper right abdominal or stomach pain
- yellow eyes and skin
- Blurred vision
- change in walking and balance
- changes in patterns and rhythms of speech
- clumsiness or unsteadiness
- dizziness or lightheadedness
- double vision
- feeling of constant movement of self or surroundings
- seeing double
- sensation of spinning
- shakiness and unsteady walk
- sleepiness or unusual drowsiness
- slurred speech
- trouble in speaking
- uncontrolled eye movements
- unsteadiness, trembling, or other problems with muscle control or coordination
- Abdominal or stomach pain
- acid or sour stomach
- back pain
- change in taste
- decreased appetite
- dry mouth
- impaired memory
- itching skin
- lack or loss of strength
- loss of taste
- muscle aches
- problems with speech or speaking
- sore throat
- stomach discomfort or upset
- stuffy or runny nose
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