Comparing Zolpidem vs ZzzQuil
| Zolpidem | ZzzQuil (diphenhydramine) |
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| Zolpidem | ZzzQuil (diphenhydramine) |
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Prescription only
Zolpidem induces sleep; however, longer-acting formulations may impair physical and mental capabilities the next day. May induce complex or dangerous sleep-related behaviors like "sleep-driving"... View more |
Prescription and OTC
Prescribed for Insomnia. ZzzQuil may also be used for purposes not listed in this medication guide. |
Related suggestions |
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| More about Zolpidem | More about ZzzQuil (diphenhydramine) | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Zolpidem has an average rating of 6.9 out of 10 from a total of 1062 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 22% reported a negative effect. |
ZzzQuil has an average rating of 3.0 out of 10 from a total of 69 ratings on Drugs.com. 17% of reviewers reported a positive effect, while 71% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Zolpidem side effects |
View all ZzzQuil side effects |
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| Drug Class | |||||||||||||||||
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None |
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| Generic Availability | |||||||||||||||||
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Lower cost generic |
N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Zolpidem prices |
View all ZzzQuil prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Ambien, Ambien CR, Edluar, Zolpimist | Other diphenhydramine brands include: Aler-Dryl, Aler-Tab, Aller-G-Time, Allergia-C, Allermax, Altaryl, Aurodryl Children's Allergy, Banaril, Banophen, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benahist-10, Benahist-50, Benoject-50, Buckley's Bedtime, Bydramine, Calm-Aid, Complete Allergy Relief, Compoz Nighttime Sleep Aid, ConRx Allergy, Dicopanol, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Dormin, DPH, Dytan, Dytuss, Genahist, Help I Can't Sleep, Histaprin, Hydramine, Hydramine Compound, Hydramine Cough Syrup, Hyrexin, Miles Nervine, Nytol, Nytol Caplet, Nytol QuickCaps, Pharbedryl, Scot-Tussin Allergy, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep Tab II, Sleep Tablets, Sleep-ettes D, Sleepinal, Sleepwell 2-nite, Snooze Fast, Sominex, Sominex Maximum Strength Caplet, Trux-adryl, Twilite, Unisom Liquid, Unisom SleepGels, Unisom SleepMelts, Unisom SleepMinis, Valu-Dryl, Vanamine PD, Vicks QlearQuil Nighttime Allergy Relief, Z-Sleep View more | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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2.6 hours |
9.3 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Some potential for abuse
Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category B
No proven risk in humans
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 484 drugs are known to interact with Zolpidem:
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A total of 450 drugs are known to interact with ZzzQuil:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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December 16, 1992 |
N/A |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
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N/A |
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| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.