ZzzQuil Interactions
There are 449 drugs known to interact with ZzzQuil (diphenhydramine), along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 431 are moderate, and 3 are minor.
- View all 449 medications that may interact with ZzzQuil
- View ZzzQuil alcohol/food interactions (1)
- View ZzzQuil disease interactions (8)
Most frequently checked interactions
View interaction reports for ZzzQuil (diphenhydramine) and the medicines listed below.
- acetaminophen
- albuterol
- amlodipine
- aspirin
- atorvastatin
- cyclobenzaprine
- famotidine
- gabapentin
- hydroxyzine
- ibuprofen
- levothyroxine
- lisinopril
- losartan
- melatonin
- meloxicam
- metformin
- multivitamin
- naproxen
- omeprazole
- pantoprazole
- prednisone
- propranolol
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
ZzzQuil alcohol/food interactions
There is 1 alcohol/food interaction with ZzzQuil (diphenhydramine).
ZzzQuil disease interactions
There are 8 disease interactions with ZzzQuil (diphenhydramine) which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
Report options
More about ZzzQuil (diphenhydramine)
- ZzzQuil consumer information
- Compare alternatives
- Reviews (68)
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy or Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Ativan
Ativan is a benzodiazepine used to treat anxiety disorders or anxiety associated with depression ...
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Ambien
Ambien (zolpidem) is a prescription sedative used to treat insomnia, helping you fall asleep and ...
Lunesta
Lunesta is a sedative and is used to treat insomnia. Lunesta's effects typically begin within 30 ...
Eszopiclone
Eszopiclone (brand name Lunesta) is a sedative and is used to treat insomnia. Eszopiclone's effects ...
Temazepam
Temazepam is used to treat insomnia (trouble sleeping). Learn about side effects, interactions and ...
Doxepin
Doxepin systemic is used for anxiety, depression, insomnia, irritable bowel syndrome, major ...
Zolpidem
Zolpidem is a sedative-hypnotic medicine used for the short-term treatment of insomnia (trouble ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
