Comparing Wellbutrin XL vs Zoloft

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Wellbutrin XL bupropion

Zoloft sertraline

Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide.

Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder... View more

Prescription only

Ratings & Reviews

View all 387 reviews

View all 1610 reviews

Drug Class

Miscellaneous antidepressants

Selective serotonin reuptake inhibitors

Side Effects

Common side effects include: dizziness, insomnia, nausea, pharyngitis, weight loss, and xerostomia.

See the full Wellbutrin XL side effects document.

Common side effects include: diarrhea, dizziness, drowsiness, dyspepsia, fatigue, insomnia, loose stools, nausea, tremor, headache, paresthesia, anorexia, decreased libido, delayed ejaculation, diaphoresis, ejaculation failure, and xerostomia.

See the full Zoloft side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	30 tablet, extended release
Dosage	150 mg/24 hours
Per Unit^*	$55.51
Cost^*	$1,665.16

View all Wellbutrin XL prices and generic prices

Quantity	30 tablet
Dosage	100 mg
Per Unit^*	$13.13
Cost^*	$393.84

View all Zoloft prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral tablet, extended release

Oral concentrate
Oral tablet

Brand Names

Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR Other sertraline brands include: Zercapli

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

30 hours

66 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 423 drugs are known to interact with Wellbutrin XL:

212 major drug interactions (924 brand and generic names)
206 moderate drug interactions (862 brand and generic names)
5 minor drug interactions (16 brand and generic names)

A total of 624 drugs are known to interact with Zoloft:

143 major drug interactions (564 brand and generic names)
474 moderate drug interactions (1948 brand and generic names)
7 minor drug interactions (35 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more

You should avoid or limit the use of alcohol while being treated with sertraline. Alcohol can... View more

Disease Interactions

First Approval Date

August 28, 2003

December 30, 1991

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

Consumer Resources

Advanced Reading

Professional Resources

Prescribing Information

Prescribing Information

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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