Comparing Wellbutrin XL vs Zoloft
| Wellbutrin XL | Zoloft |
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| Wellbutrin XL (bupropion) | Zoloft (sertraline) |
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Prescription only
Prescribed for Major Depressive Disorder, Depression, Seasonal Affective Disorder. Wellbutrin XL may also be used for purposes not listed in this medication guide. |
Prescription only
Zoloft is an effective antidepressant with less potential for drowsiness than many other antidepressants. Prescribed for Panic Disorder, Obsessive Compulsive Disorder, Major Depressive Disorder... View more |
Related suggestions Depression
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| More about Wellbutrin XL (bupropion) | More about Zoloft (sertraline) | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Wellbutrin XL has an average rating of 7.4 out of 10 from a total of 466 ratings on Drugs.com. 66% of reviewers reported a positive effect, while 16% reported a negative effect. |
Zoloft has an average rating of 7.2 out of 10 from a total of 1865 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 19% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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Common side effects include:
See also: Wellbutrin XL side effects in more detail. |
Common side effects include:
See also: Zoloft side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Wellbutrin XL prices and generic prices |
View all Zoloft prices and generic prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Other bupropion brands include: Aplenzin, Budeprion, Budeprion SR, Forfivo XL, Wellbutrin SR |
N/A |
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| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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30 hours |
66 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 484 drugs are known to interact with Wellbutrin XL:
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A total of 644 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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August 28, 2003 |
December 30, 1991 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.